Human Anti-TACSTD2 (clone AR47A6.4.2 (AR002)) scFv-Fc Chimera (CAT#: VS-0125-FY17)
The Trop2-specific anti-scFv-Fc is an innovative antibody therapy that effectively targets pancreatic cancer cells by precisely recognizing and binding to the Trop2 antigen. This specific interaction enhances the drug's selectivity for cancer cells while potentially reducing damage to normal cells, thereby lowering side effects. Research has shown that the use of this antibody can significantly inhibit the growth of pancreatic cancer and improve patient survival rates. Therefore, anti-scFv-Fc not only offers a new possibility for the treatment of pancreatic cancer but also opens up new avenues for the development of future cancer immunotherapies.
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line MCF7
(Immunofluorescent staining of human cell line MCF7 shows localization to nucleoli & plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/55067/if_selected.jpg
(Immunofluorescent staining of human cell line MCF7 shows localization to nucleoli & plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/55067/if_selected.jpg
Figure 2 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to vesicles.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/55067/893_A3_7_blue_red_green.jpg
(Immunofluorescent staining of human cell line A-431 shows localization to vesicles.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/55067/893_A3_7_blue_red_green.jpg
Figure 3 Urinary bladder
(Urothelial cells
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/43104/93730_A_6_5.jpg
(Urothelial cells
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/43104/93730_A_6_5.jpg
Figure 4 RNA cell line category: Cell line enhanced (A-431, CAPAN-2, HaCaT, RT4)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000184292-TACSTD2
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000184292-TACSTD2
Figure 4 RNA cell line category: Cell line enhanced (A-431, CAPAN-2, HaCaT, RT4)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000184292-TACSTD2
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000184292-TACSTD2
Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Species Reactivity
- Human
- Clone
- AR47A6.4.2 (AR002)
- Applications
- ELISA, Inhibition, Cytotoxicity
- Related Disease
- Pancreatic cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Stabilizer
- No Stabilizers
- Sterility
- 0.2 μM filtered
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The function of anti-scFv-Fc mainly includes recognizing and binding to the Trop2 antigen, thereby effectively marking tumor cells. Additionally, it has the ability to recruit immune cells to induce cytotoxicity and produce cytokines, thereby enhancing the anti-tumor immune response. The presence of the Fc portion may confer greater stability and extend its half-life in the body. These characteristics make anti-scFv-Fc a promising candidate in cancer therapy.
Target
- Alternative Names
- EGP1; GP50; M1S1; EGP-1; TROP2; GA7331; GA733-1
- Gene ID
- 4070
- UniProt ID
- P09758
- Sequence Similarities
- Belongs to the EPCAM family.
- Cellular Localization
- Amyloid, Membrane
- Post Translation Modifications
- The N-terminus is blocked.
- Protein Refseq
- NP_002344.2
- Function
- May function as a growth factor receptor.
Recommended Products
Secondary Antibody
Isotype Control
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1222z | Mouse Anti-TACSTD2 Recombinant Antibody (clone 22B1) | WB, IP, IF, IHC, ELISA | Mouse IgG1, κ |
| MOB-1932CT | Recombinant Mouse anti-Human TACSTD2 Monoclonal antibody (273-57.3) | ICC/IF, IHC-P | |
| MRO-2244-CN | Rabbit Anti-TACSTD2 Polyclonal Antibody (MRO-2244-CN) | WB, IF, IHC | Rabbit IgG |
| HPAB-0653-WJ | Mouse Anti-TACSTD2 Recombinant Antibody (HPAB-0653-WJ) | ELISA | Mouse IgG |
| VS7-0425-WR947 | Mouse Anti-TACSTD2 Recombinant Antibody (clone 6H10B11) | WB, IHC, FC | Mouse IgG2b |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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