Anti-GPNMB (CR011)-vcMMAE ADC (CAT#: ADC-120LCT)
This ADC product is composed of an anti-glycoprotein NMB (GPNMB) antibody (clone CR011) conjuagated via a vc linker to MMAE (CR011-vcMMAE). It has demonstrated a response in GPNMB-positive melanoma treatment by a MOA (Mechanism of Action) of Depolymerize Microtubules.
Specific Inquiry
RNA Expression
Figure 1 RNA cell line category: Cell line enriched (ASC diff)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000136235-GPNMB
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000136235-GPNMB
Specifications
- Antibody Overview
- Fully Human Monoclonal Antibody (CR011) Anti-GPNMB
- Clone
- CR011
- Linker
- VC (valine-citrulline)
- Linker Class/Description
- Peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.
- Drug
- MMAE (Monomethyl auristatin E)
- Drug Class/Description
- Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.
Target
- Introduction
- The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- Alternative Names
- GPNMB; glycoprotein (transmembrane) nmb; NMB; HGFIN; transmembrane glycoprotein NMB; osteoactivin; glycoprotein NMB; glycoprotein nmb-like protein; transmembrane glycoprotein HGFIN;
- Gene ID
- 10457
- UniProt ID
- Q14956
Downloads
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Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-1138-VHH | Recombinant Anti-Human GPNMB VHH Single Domain Antibody | WB, ICC, ChiP, FA, ELISA | Llama VHH |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-751 | Human Anti-GPNMB Recombinant Antibody (clone Glembatumumab) | WB, IF, IP, Neut, FuncS, ELISA, FC | Human IgG2, κ |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4197 | Rabbit Anti-GPNMB Recombinant Antibody (clone SI275DS) | ELISA | Rabbit IgG |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0005-LS-F(E) | Rabbit Anti-GPNMB Recombinant Antibody; Fab Fragment (HPAB-0005-LS-F(E)) | FC | Rabbit Fab |
| HPAB-0006-LS-F(E) | Human Anti-GPNMB Recombinant Antibody (clone mAb 1.15.1); Fab Fragment | ELISA | Human Fab |
| HPAB-1535-FY-S(P) | Human Anti-GPNMB Recombinant Antibody (clone 1.10.2); Fab Fragment | Inhib, ELISA | Human Fab |
| HPAB-1536-FY-S(P) | Human Anti-GPNMB Recombinant Antibody (clone 1.2.2); Fab Fragment | Inhib, ELISA | Human Fab |
| HPAB-1537-FY-S(P) | Human Anti-GPNMB Recombinant Antibody (clone 1.7.1); Fab Fragment | Inhib, ELISA | Human Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0005-LS-S(P) | Rabbit Anti-GPNMB Recombinant Antibody; scFv Fragment (HPAB-0005-LS-S(P)) | FC | Rabbit scFv |
| HPAB-0006-LS-S(P) | Human Anti-GPNMB Recombinant Antibody (clone mAb 1.15.1); scFv Fragment | ELISA | Human scFv |
| HPAB-1535-FY-F(E) | Human Anti-GPNMB Recombinant Antibody (clone 1.10.2); scFv Fragment | Inhib, ELISA | Human scFv |
| HPAB-1536-FY-F(E) | Human Anti-GPNMB Recombinant Antibody (clone 1.2.2); scFv Fragment | Inhib, ELISA | Human scFv |
| HPAB-1537-FY-F(E) | Human Anti-GPNMB Recombinant Antibody (clone 1.7.1); scFv Fragment | Inhib, ELISA | Human scFv |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-020CQ | Mouse Anti-GPNMB Recombinant Antibody (clone YC095) | WB, IHC, FC | Mouse IgG2b |
| MOB-122CQ | Rat Anti-GPNMB Recombinant Antibody (clone YC096) | ELISA, WB | Rat IgG2b |
| MOB-123CQ | Rat Anti-GPNMB Recombinant Antibody (clone YC097), eFluor® 660 | FC | Rat IgG2a |
| HPAB-1535-FY | Human Anti-GPNMB Recombinant Antibody (clone 1.10.2) | Inhib, ELISA | Human IgG |
| HPAB-1536-FY | Human Anti-GPNMB Recombinant Antibody (clone 1.2.2) | Inhib, ELISA | Human IgG |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-751 | Afuco™ Anti-GPNMB ADCC Recombinant Antibody (Glembatumumab), ADCC Enhanced | IF, IP, Neut, FuncS, ELISA | ADCC enhanced antibody |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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