Anti-GPNMB-vc-MMAE ADC
CAT#: ADC-004LZY
This ADC product is composed of an anti-GPNMB antibody conjugated via vc linker to MMAE (Glembatumumab-vc-MMAE). It is in Phase II clinical trials and has demonstrated a response in Metastatic breast cancer and melanoma treatment by a MOA (Mechanism of Action) of microtubules depolymerizing.
Gene Expression
RNA Expression
Figure 1 RNA cell line category: Cell line enriched (ASC diff)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000136235-GPNMB
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Specifications
- Antibody Overview
- Glembatumumab(Fully Human Anti-GPNMB IgG2)
- Antibody Isotype
- IgG2
- Linker
- VC (Valine-citrulline)
- Linker Class/Description
- Class: Enzymatically cleavable linker-Peptide linker
Description: peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.
- Drug
- MMAE (monomethyl auristatin E)
- Drug Class/Description
- Class: Auristatin
Description: Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.
Target
- Introduction
- The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- Alternative Names
- GPNMB; glycoprotein (transmembrane) nmb; NMB; HGFIN; transmembrane glycoprotein NMB; osteoactivin; glycoprotein NMB; glycoprotein nmb-like protein; transmembrane glycoprotein HGFIN;
- Gene ID
- 10457
- UniProt ID
- Q14956
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MSDS
COA
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See other products for "GPNMB"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-1138-VHH | Recombinant Anti-Human GPNMB VHH Single Domain Antibody | WB, ICC, ChiP, FA, ELISA | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-751 | Human Anti-GPNMB Recombinant Antibody (clone Glembatumumab) | WB, IF, IP, Neut, FuncS, ELISA, FC | Human IgG2, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4197 | Rabbit Anti-GPNMB Recombinant Antibody (clone SI275DS) | ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0005-LS-F(E) | Rabbit Anti-GPNMB Recombinant Antibody; Fab Fragment (HPAB-0005-LS-F(E)) | FC | Rabbit Fab |
| HPAB-0006-LS-F(E) | Human Anti-GPNMB Recombinant Antibody Fab Fragment (HPAB-0006-LS-F(E)) | ELISA | Human Fab |
| HPAB-1535-FY-S(P) | Human Anti-GPNMB Recombinant Antibody (clone 1.10.2); Fab Fragment | Inhib, ELISA | Human Fab |
| HPAB-1536-FY-S(P) | Human Anti-GPNMB Recombinant Antibody (clone 1.2.2); Fab Fragment | Inhib, ELISA | Human Fab |
| HPAB-1537-FY-S(P) | Human Anti-GPNMB Recombinant Antibody (clone 1.7.1); Fab Fragment | Inhib, ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0005-LS-S(P) | Rabbit Anti-GPNMB Recombinant Antibody; scFv Fragment (HPAB-0005-LS-S(P)) | FC | Rabbit scFv |
| HPAB-0006-LS-S(P) | Human Anti-GPNMB Recombinant Antibody scFv Fragment (HPAB-0006-LS-S(P)) | ELISA | Human scFv |
| HPAB-1535-FY-F(E) | Human Anti-GPNMB Recombinant Antibody (clone 1.10.2); scFv Fragment | Inhib, ELISA | Human scFv |
| HPAB-1536-FY-F(E) | Human Anti-GPNMB Recombinant Antibody (clone 1.2.2); scFv Fragment | Inhib, ELISA | Human scFv |
| HPAB-1537-FY-F(E) | Human Anti-GPNMB Recombinant Antibody (clone 1.7.1); scFv Fragment | Inhib, ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-020CQ | Mouse Anti-GPNMB Recombinant Antibody (clone YC095) | WB, IHC, FC | Mouse IgG2b |
| MOB-122CQ | Rat Anti-GPNMB Recombinant Antibody (clone YC096) | ELISA, WB | Rat IgG2b |
| MOB-123CQ | Rat Anti-GPNMB Recombinant Antibody (clone YC097) | FC | Rat IgG2a |
| VS3-XY778 | Mouse Anti-GPNMB Recombinant Antibody (clone 7C10E5) | ELISA, WB, IHC | Mouse IgG1 |
| VS13-YC462 | Rabbit Anti-GPNMB Recombinant Antibody (VS13-YC462) | IHC-P | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-751 | Afuco™ Anti-GPNMB ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-751) | IF, IP, Neut, FuncS, ELISA | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY944 | Anti-GPNMB Immunohistochemistry Kit | IHC | |
| VS-0525-XY2890 | Anti-Human GPNMB Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY114 | Human Anti-GPNMB scFv-Fc Chimera (VS-0425-FY114) | ELISA, FC | Human IgG2, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC81 | Recombinant Anti-GPNMB Vesicular Antibody, EV Displayed (VS-0425-YC81) | ELISA, FC, Neut, Cell-uptake |
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