Anti-STEAP-1 (clone 120v.24)-MC-vc-PAB-MMAE ADC (CAT#: ADC-174CL)

• Antibody Overview
• Humanized Anti-STEAP-1 Antibody 120v.24

• Clone
• 120v.24

• Linker
• MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl)

• Linker Class/Description
• Class: Enzymatically cleavable linkers-Peptide linkers
  Description: peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.

• Drug
• MMAE (Monomethyl auristatin E)

• Drug Class/Description
• Class: Auristatin
  Description: Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

• Introduction
• This gene is predominantly expressed in prostate tissue, and is found to be upregulated in multiple cancer cell lines. The gene product is predicted to be a six-transmembrane protein, and was shown to be a cell surface antigen significantly expressed at cell-cell junctions. [provided by RefSeq, Jul 2008]

• Alternative Names
• STEAP1; six transmembrane epithelial antigen of the prostate 1; STEAP; PRSS24; metalloreductase STEAP1; six-transmembrane epithelial antigen of prostate 1;

• Gene ID
• 26872

• UniProt ID
• Q9UHE8

• ADC-175CL
• Anti-STEAP-1 (clone 120v.24)-MC-MMAF ADC

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