APC-A*01:01/Human DNMT1 (YLDDPDLKY) MHC Tetramer (CAT#: MHC-LC4421)

This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of human DNMT1 of peptide YLDDPDLKY covering 359-367 and A*01:01 molecule. The pMHC tetramer recognizes CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.


Specific Inquiry
  • Size:
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location and Protein Expression
Normal Tissue
RNA Expression

Specifications

  • Allele
  • A*01:01
  • Class
  • Class I
  • Antigen
  • DNMT1
  • Antigen Species
  • Human
  • Peptide
  • YLDDPDLKY
  • Range
  • 359-367
  • Conjugate
  • APC
  • Application
  • FCM

Target

  • Antigen Introduction
  • This gene encodes an enzyme that transfers methyl groups to cytosine nucleotides of genomic DNA. This protein is the major enzyme responsible for maintaining methylation patterns following DNA replication and shows a preference for hemi-methylated DNA. Methylation of DNA is an important component of mammalian epigenetic gene regulation. Aberrant methylation patterns are found in human tumors and associated with developmental abnormalities. Variation in this gene has been associated with cerebellar ataxia, deafness, and narcolepsy, and neuropathy, hereditary sensory, type IE. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
  • Alternative Names
  • DNMT1; DNA (cytosine-5)-methyltransferase 1; AIM; DNMT; MCMT; CXXC9; HSN1E; ADCADN; m.HsaI

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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