PE-A*68:02/Human ACTB (TLKYPIEHGI) MHC Tetramer
CAT#: MHC-LC4206
This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of human ACTB of peptide TLKYPIEHGI covering 66-75 and A*68:02 molecule. The pMHC tetramer recognizes CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human tonsil
Immunohistochemical staining of human tonsil shows strong cytoplasmic positivity in reaction center cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2621/ihc_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Endothelial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/41271/103139_B_7_5.jpg
Normal Tissue
Figure 3 Testis
Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Leydig cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2621/6575_A_6_6.jpg
Normal Tissue
Figure 4 Lymph node
Germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/41271/103139_A_7_8.jpg
Normal Tissue
Figure 5 Colon
Enterocytes - Microvilli Staining: High Intensity: Strong
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/41271/103139_A_8_3.jpg
Normal Tissue
Figure 6 Kidney
Cells in glomeruli Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Cells in tubules Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/41271/103139_A_9_5.jpg
RNA Expression
Figure 7 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000075624-ACTB
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Specifications
- Allele
- A*68:02
- Class
- Class I
- MHC Species
- Human
- Antigen
- ACTB
- Antigen Species
- Human
- Peptide
- TLKYPIEHGI
- Range
- 66-75
- Conjugate
- PE
- Application
- FCM
Target
- Antigen Introduction
- This gene encodes one of six different actin proteins. Actins are highly conserved proteins that are involved in cell motility, structure, and integrity. This actin is a major constituent of the contractile apparatus and one of the two nonmuscle cytoskeletal actins. [provided by RefSeq, Jul 2008]
- Alternative Names
- ACTB; Actin, cytoplasmic 1; BRWS1; PS1TP5BP1
- Gene ID
- 60
- UniProt ID
- P60709
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Customer Review
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Impressive Specificity
This tetramer exceeded my expectations in terms of specificity. Our lab used it in flow cytometry, and the results were clear and precise. It made identifying CD8 T cells that recognize the ACTB peptide effortless, forming a critical part of our immunological studies. Highly recommend for any similar research needs!
High Performance in Flow Cytometry
The high fluorescence intensity from the PE conjugation was ideal for flow cytometry applications. This tetramer enabled us to track T cell responses to ACTB confidently. It's become a key tool in our investigations, streamlining our workflow significantly.
Highly Recommend
I recommend this ACTB MHC Tetramer to any researcher aiming to explore T cell responses. The precision, reliability, and ease of use make it indispensable for detailed immunological research, reinforcing our lab's capacity to drive meaningful scientific outcomes.
Q&As
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Can this tetramer be used for flow cytometry applications?
A: Yes, the PE-A*68:02/Human ACTB MHC Tetramer is explicitly conjugated with PE for use in flow cytometry, allowing researchers to analyze and quantify specific T cell populations efficiently.
-
Is this tetramer suitable for analyzing all cell types?
A: The tetramer is primarily used for analyzing CD8 T cells, particularly focusing on their response to specific antigenic peptides. Its use is best suited for these cell types in immunological studies.
-
How does this tetramer align with research goals in cancer immunology?
A: Given its precision in identifying CD8 T cell responses, it is invaluable in cancer immunology for evaluating T cell involvement in tumor recognition and potential anti-tumor responses.
View the frequently asked questions answered by Creative Biolabs Support.
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Downloadable Resources
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COA
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