Loading...
ACTB
This gene encodes one of six different actin proteins. Actins are highly conserved proteins that are involved in cell motility, structure, integrity, and intercellular signaling. The encoded protein is a major constituent of the contractile apparatus and one of the two nonmuscle cytoskeletal actins that are ubiquitously expressed. Mutations in this gene cause Baraitser-Winter syndrome 1, which is characterized by intellectual disability with a distinctive facial appearance in human patients. Numerous pseudogenes of this gene have been identified throughout the human genome.
Protein class
Disease related genes, Human disease related genes, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (monocytes, Pancreatic endocrine cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix (PubMed:28604741, PubMed:16685646). Each actin can bind to 4 others (PubMed:28604741, PubMed:16685646). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs (PubMed:17289661). Component of the BAF complex, which includes at least actin (ACTB), ARID1A, ARID1B/BAF250, SMARCA2, SMARCA4/BRG1, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57 SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more of SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C (PubMed:18765789). In muscle cells, the BAF complex also contains DPF3 (PubMed:18765789). Found in a complex with XPO6, Ran, ACTB and PFN1 (PubMed:14592989). Interacts with XPO6 and EMD (PubMed:15328537). Interacts with ERBB2 (PubMed:21555369). Interacts with GCSAM (PubMed:17823310). Interacts with TBC1D21 (By similarity). Interacts with CPNE1 (via VWFA domain) and CPNE4 (via VWFA domain) (By similarity). Interacts with DHX9 (via C-terminus); this interaction is direct and mediates the attachment to nuclear ribonucleoprotein complexes (PubMed:11687588). Interacts with FAM107A (PubMed:21969592, PubMed:28604741).
More Types Infomation
- PE-A*02:02/Human ACTB (RLDLAGRDL) MHC Tetramer (MHC-LC3888)
-
- Class: Class I
- Antigen: ACTB
- Antigen Species: Human
- Peptide: RLDLAGRDL
- Conjugate: PE
- PE-A*02:02/Human ACTB (ALPHAILRL) MHC Tetramer (MHC-LC3887)
-
- Class: Class I
- Antigen: ACTB
- Antigen Species: Human
- Peptide: ALPHAILRL
- Conjugate: PE
- PE-A*02:03/Human ACTB (ALPHAILRL) MHC Tetramer (MHC-LC3886)
-
- Class: Class I
- Antigen: ACTB
- Antigen Species: Human
- Peptide: ALPHAILRL
- Conjugate: PE
- PE-A*02:06/Human ACTB (ALPHAILRL) MHC Tetramer (MHC-LC3885)
-
- Class: Class I
- Antigen: ACTB
- Antigen Species: Human
- Peptide: ALPHAILRL
- Conjugate: PE
- PE-A*02:01/Human ACTB (ALPHAILRL) MHC Tetramer (MHC-LC3884)
-
- Class: Class I
- Antigen: ACTB
- Antigen Species: Human
- Peptide: ALPHAILRL
- Conjugate: PE
- PE-A*02:01/Human ACTB (AMYVAIQAV) MHC Tetramer (MHC-LC3883)
-
- Class: Class I
- Antigen: ACTB
- Antigen Species: Human
- Peptide: AMYVAIQAV
- Conjugate: PE
- PE-A*68:02/Human ACTB (AMYVAIQAV) MHC Tetramer (MHC-LC3882)
-
- Class: Class I
- Antigen: ACTB
- Antigen Species: Human
- Peptide: AMYVAIQAV
- Conjugate: PE
- PE-A*02:06/Human ACTB (AMYVAIQAV) MHC Tetramer (MHC-LC3881)
-
- Class: Class I
- Antigen: ACTB
- Antigen Species: Human
- Peptide: AMYVAIQAV
- Conjugate: PE
- PE-A*02:03/Human ACTB (AMYVAIQAV) MHC Tetramer (MHC-LC3880)
-
- Class: Class I
- Antigen: ACTB
- Antigen Species: Human
- Peptide: AMYVAIQAV
- Conjugate: PE
- PE-A*02:02/Human ACTB (AMYVAIQAV) MHC Tetramer (MHC-LC3879)
-
- Class: Class I
- Antigen: ACTB
- Antigen Species: Human
- Peptide: AMYVAIQAV
- Conjugate: PE
- PE-A*02:02/Human ACTB (GMGQKDSYV) MHC Tetramer (MHC-LC3878)
-
- Class: Class I
- Antigen: ACTB
- Antigen Species: Human
- Peptide: GMGQKDSYV
- Conjugate: PE
- PE-A*02:03/Human ACTB (GMGQKDSYV) MHC Tetramer (MHC-LC3877)
-
- Class: Class I
- Antigen: ACTB
- Antigen Species: Human
- Peptide: GMGQKDSYV
- Conjugate: PE
- PE-A*02:01/Human ACTB (GMGQKDSYV) MHC Tetramer (MHC-LC3876)
-
- Class: Class I
- Antigen: ACTB
- Antigen Species: Human
- Peptide: GMGQKDSYV
- Conjugate: PE
- PE-A*02:01/Human ACTB (RLDLAGRDL) MHC Tetramer (MHC-LC3889)
-
- Class: Class I
- Antigen: ACTB
- Antigen Species: Human
- Peptide: RLDLAGRDL
- Conjugate: PE
- PE-A*02:01/Human ACTB (DLTDYLMKI) MHC Tetramer (MHC-LC3890)
-
- Class: Class I
- Antigen: ACTB
- Antigen Species: Human
- Peptide: DLTDYLMKI
- Conjugate: PE
- PE-A*68:02/Human ACTB (DLTDYLMKI) MHC Tetramer (MHC-LC3891)
-
- Class: Class I
- Antigen: ACTB
- Antigen Species: Human
- Peptide: DLTDYLMKI
- Conjugate: PE
- PE-A*02:06/Human ACTB (DLTDYLMKI) MHC Tetramer (MHC-LC3892)
-
- Class: Class I
- Antigen: ACTB
- Antigen Species: Human
- Peptide: DLTDYLMKI
- Conjugate: PE
- PE-A*02:03/Human ACTB (DLTDYLMKI) MHC Tetramer (MHC-LC3893)
-
- Class: Class I
- Antigen: ACTB
- Antigen Species: Human
- Peptide: DLTDYLMKI
- Conjugate: PE
- PE-A*02:02/Human ACTB (DLTDYLMKI) MHC Tetramer (MHC-LC3894)
-
- Class: Class I
- Antigen: ACTB
- Antigen Species: Human
- Peptide: DLTDYLMKI
- Conjugate: PE
- PE-A*02:03/Human ACTB (FLGMESCGI) MHC Tetramer (MHC-LC3895)
-
- Class: Class I
- Antigen: ACTB
- Antigen Species: Human
- Peptide: FLGMESCGI
- Conjugate: PE
Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us
Can't find the products you're looking for? Try to filter in the left sidebar.Filter By Tag
For Research Use Only. Not For Clinical Use.