Anti-ACTB Recombinant Antibody Products

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Anti-ACTB Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs proudly offers advanced recombinant antibodies targeting ACTB to support a wide range of biomedical research needs. Through our sophisticated production platforms and rigorous quality control measures, we deliver reagents that consistently meet high standards of accuracy, stability, and reproducibility. Our extensive catalog reflects a dedication to providing solutions that enhance experimental reliability and scientific progress. We also place strong emphasis on personalized technical support, ensuring that researchers receive timely guidance throughout their projects. Partnering with Creative Biolabs means gaining access to innovative antibody technologies and a research-focused team committed to helping you move your scientific work forward with confidence and efficiency.

ACTB: A Ubiquitous Cytoskeletal Regulator in Cancer Neurodegeneration and Developmental Disorders

Beta-actin, encoded by the ACTB gene, is a fundamental and highly conserved component of the cytoskeleton, playing a vital role in preserving cell shape, enabling movement, and facilitating intracellular transport. Alterations in its expression or function have been increasingly linked to a broad range of diseases. In cancer, its dysregulation promotes tumor growth by enhancing cell migration, invasion, and modifying adhesion properties, thereby supporting metastasis. Genetic variants influencing ACTB expression have been found in developmental disorders, especially those involving craniofacial defects and intellectual disabilities, highlighting the importance of cytoskeletal integrity during early development. Immune system disorders may also arise from abnormal beta-actin dynamics, which can hinder immune cell mobility and antigen processing, weakening the body’s defense. Additionally, emerging research connects beta-actin instability to neurodegenerative diseases such as Alzheimer’s and amyotrophic lateral sclerosis, where cytoskeletal breakdown is a hallmark. The protein also plays a key role in tissue repair and wound healing, emphasizing its significance in maintaining normal physiological functions. Due to its widespread presence and critical cellular functions, beta-actin is not only commonly used as a reference marker but also recognized as a potential factor in disease when its regulation is impaired. Ongoing studies continue to explore its multifaceted role in both fundamental biology and clinical contexts.

Alternative Names

Complement Actin Beta; PS1TP5-Binding Protein 1; Beta Cytoskeletal Actin; Actin, Cytoplasmic 1; Beta-Actin; PS1TP5BP1; BRWS1

Background

This gene encodes one of the six actin isoforms, a group of evolutionarily conserved proteins essential for cellular movement, structural support, mechanical integrity, and signaling between cells. The protein product is a key element of the contractile system and belongs to the two non-muscle actins that are broadly expressed across various cell types. Genetic mutations in this gene are linked to Baraitser-Winter syndrome 1, a condition marked by intellectual disability and distinctive craniofacial features. Additionally, multiple pseudogenes related to this gene have been found throughout the human genome.

Anti-ACTB rAb Products

We are dedicated to accelerating research and discovery by providing our premium anti-ACTB recombinant antibody products that combine the highest quality, exceptional value, and comprehensive top-tier technical support. Our unwavering commitment to excellence ensures these products not only meet but exceed industry standards, empowering researchers with reliable tools to drive their scientific progress efficiently.

Creative Quality Control

To accelerate the advancement of biopharmaceutical research and development through to commercialization, our core values are rooted in a customer-centric approach, with a primary focus on fulfilling customer needs for product quality. We have established a rigorous quality management system to ensure product excellence. By not only meeting but exceeding customer expectations, we help clients save valuable time in drug development.

Customer Reviews

Excellent

Va**n
Mouse Anti-ACTB Recombinant Antibody (clone 1D12E12B5) (CAT#: ZG-0296U)

We performed Western blot analysis on human epithelial cell lysates using the Mouse Anti-ACTB Recombinant Antibody. The antibody yielded distinct and precise bands at the anticipated molecular weight, with minimal background noise. It integrated seamlessly with our usual protocol without needing additional adjustments. The signal remained stable across several experiments, facilitating accurate quantification. Overall, it proved to be a dependable choice for detecting beta-actin as a loading control in our protein assays.

10/Oct/2024

Excellent

M**en
Rabbit Anti-ACTB Recombinant Antibody (clone Q20-K), FITC (CAT#: ZG-0423U)

This rabbit anti-ACTB recombinant antibody worked well in my FC with Jurkat and PBMCs, showing clear staining without excessive background. Tested WB on HeLa and HEK293 lysates—sharp bands at ~42kDa. Also tried IHC-P on human colon tissue, giving consistent cytoplasmic staining. Minimal optimization needed for dilutions. Solid performance across cell and tissue samples for ACTB detection.

16/Jul/2024

Excellent

De**d
Recombinant Mouse Anti-ACTB Antibody (clone 8H5-1H4-9E8) (CAT#: VS3-FY31)

Tested this anti-ACTB antibody on FFPE tonsil and colon tissue for IHC-P. Gave crisp cytoplasmic staining at 1:150 dilution with 20min HIER (pH6). Worked consistently across batches, though epithelial cells showed slightly stronger signal than stromal areas. Background was clean with proper blocking. Didn't try other applications, but for routine IHC-P it's been dependable.

15/Apr/2023

rAb Production

Backed by extensive expertise in recombinant antibody development, we produce thoroughly tested antibodies that adhere to strict performance standards. Our streamlined production workflows ensure dependable reagents with efficient turnaround times, while our knowledgeable team offers tailored support to help overcome experimental hurdles. We are dedicated to delivering high-quality, application-ready solutions that align with the practical demands of modern research.

Featured Anti-ACTB Recombinant Antibody Production Platforms
Fig.3 Milligram-scale anti-ACTB recombinant antibody production.

Fig.4 Gram-scale anti-ACTB recombinant antibody production.

rAb Modalities

Creative Biolabs strives to offer researchers an extensive selection of top-tier recombinant antibodies in a variety of formats. Our deep knowledge of recombinant antibody technology covers a wide range of sophisticated engineering techniques, while our outstanding custom engineering solutions are carefully tailored to meet the specific needs of your research projects.

Fig.5 Full Length Anti-ACTB Recombinant Antibody Production and Modalities.

For more information about ACTB or assistance with your experiments, please contact us by phone or email. Our technical specialists are ready to provide guidance on antibody performance, protocol optimization, or troubleshooting—ensuring your research stays on track. Whether you need application advice or product details, we're here to help. Contact us today for personalized support.