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    PE-A2/Human IRF6 (GLYPGLIWL) MHC Tetramer (CAT#: MHC-LC1956)

    This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of human IRF6 of peptide GLYPGLIWL covering 21-29 and A2 molecule. The pMHC tetramer recognizes CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.

    Specific Inquiry
    • Size:
    Custom Production

    MHC tetramer custom production provides a vital tool for researchers seeking to understand and manipulate T-cell immunity with exceptional precision. Please specify your requirements, including peptide sequence, MHC allele, and desired fluorophore etc. We will respond as soon as possible with a tailored solution.

    Peptide Sequence *:
    Allele Requested *:
    Antigen Species:
    Antigen Molecule:
    Sequence Position:
    Form Requested *:
    Conjugation *:
    Size *:
    Comments:

    Disclaimer: Please note that the MHC reagents we offered have been produced with strict quality control (including gene sequencing, affinity purification, SDS-PAGE analysis, and verification of biotinylation), but many have not been confirmed to stain or activate specific T cells.

    We require custom production
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Subcellular Location and Protein Expression
    Figure 1 IF staining of human cell line HaCaT
    Figure 1 IF staining of human cell line HaCaT
    (Immunofluorescent staining of human cell line HaCaT shows localization to nucleoplasm, cytosol & cell junctions.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/63121/1576_F9_2_selected.jpg
    Figure 2 IF staining of human cell line A-431
    Figure 2 IF staining of human cell line A-431
    (Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm & cytosol.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/63121/1685_F8_1_blue_red_green.jpg
    Normal Tissue
    Figure 3 Cerebral cortex
    Figure 3 Cerebral cortex
    (Endothelial cells
    Staining:Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous nuclear
    Glial cells
    Staining:Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Nuclear
    Neuronal cells
    Staining:Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/63121/154587_B_9_5.jpg
    Figure 4 Colon
    Figure 4 Colon
    (Glandular cells
    Staining:Medium
    Intensity: Moderate
    Quantity: 75%-25%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/63121/154587_A_9_3.jpg
    Figure 5 Liver
    Figure 5 Liver
    (Hepatocytes
    Staining:Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Nuclear)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/63121/154587_A_7_4.jpg
    Figure 6 Kidney
    Figure 6 Kidney
    (Cells in tubules
    Staining:Medium
    Intensity: Moderate
    Quantity: 75%-25%
    Location: Cytoplasmic/membranous nuclear)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/63121/154587_A_8_5.jpg
    Figure 7 Testis
    Figure 7 Testis
    (Spermatogonia cells
    Staining:Medium
    Intensity: Moderate
    Quantity: 75%-25%)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/63121/154587_A_6_6.jpg
    Figure 8 Skin
    Figure 8 Skin
    (Epidermal cells
    Staining:Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranousnucl ear)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/63121/154587_B_5_8.jpg
    RNA Expression
    Figure 9 RNA cell line category: Cell line enhanced (A-431, HaCaT, HBEC3-KT, hTCEpi, hTERT-HME1, RT4)
    Figure 9 RNA cell line category: Cell line enhanced (A-431, HaCaT, HBEC3-KT, hTCEpi, hTERT-HME1, RT4)
    (Cell lines ordered by descending RNA expression order.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000117595-IRF6

    Specifications

    • Allele
    • A2
    • Class
    • Class I
    • MHC Species
    • Human
    • Antigen
    • IRF6
    • Antigen Species
    • Human
    • Peptide
    • GLYPGLIWL
    • Range
    • 21-29
    • Conjugate
    • PE
    • Application
    • FCM

    Target

    • Antigen Introduction
    • This gene encodes a member of the interferon regulatory transcription factor (IRF) family. Family members share a highly-conserved N-terminal helix-turn-helix DNA-binding domain and a less conserved C-terminal protein-binding domain. The encoded protein may be a transcriptional activator. Mutations in this gene can cause van der Woude syndrome and popliteal pterygium syndrome. Mutations in this gene are also associated with non-syndromic orofacial cleft type 6. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2011]
    • Alternative Names
    • IRF6; Interferon regulatory factor 6; LPS; PIT; PPS; VWS; OFC6; PPS1; VWS1

    Downloads

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