Mouse Anti-IRF6 Recombinant Antibody (clone ZN106) (CAT#: VS3-FY1584)
This is a pathological recombinant antibody, which is a mouse IgG2b antibody. It exhibits high specificity and affinity for human IRF6. It can work in immunohistochemistry assay. The following concentration ranges are recommended starting points for this product: immunohistochemistry with a dilution of 1/50-1/100.
Specific Inquiry
Subcellular Location and Protein Expression
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line HaCaT
(Immunofluorescent staining of human cell line HaCaT shows localization to nucleoplasm, cytosol & cell junctions.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/63121/1576_F9_2_selected.jpg
(Immunofluorescent staining of human cell line HaCaT shows localization to nucleoplasm, cytosol & cell junctions.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/63121/1576_F9_2_selected.jpg
Figure 2 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm & cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/63121/1685_F8_1_blue_red_green.jpg
(Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm & cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/63121/1685_F8_1_blue_red_green.jpg
Figure 3 Cerebral cortex
(Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
Glial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Nuclear
Neuronal cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/63121/154587_B_9_5.jpg
(Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
Glial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Nuclear
Neuronal cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/63121/154587_B_9_5.jpg
Figure 4 Colon
(Glandular cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/63121/154587_A_9_3.jpg
(Glandular cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/63121/154587_A_9_3.jpg
Figure 5 Liver
(Hepatocytes
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/63121/154587_A_7_4.jpg
(Hepatocytes
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/63121/154587_A_7_4.jpg
Figure 6 Kidney
(Cells in tubules
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/63121/154587_A_8_5.jpg
(Cells in tubules
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/63121/154587_A_8_5.jpg
Figure 7 Testis
(Spermatogonia cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/63121/154587_A_6_6.jpg
(Spermatogonia cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/63121/154587_A_6_6.jpg
Figure 8 Skin
(Epidermal cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranousnucl ear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/63121/154587_B_5_8.jpg
(Epidermal cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranousnucl ear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/63121/154587_B_5_8.jpg
Figure 9 RNA cell line category: Cell line enhanced (A-431, HaCaT, HBEC3-KT, hTCEpi, hTERT-HME1, RT4)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000117595-IRF6
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000117595-IRF6
Specifications
- Host Species
- Mouse
- Type
- Mouse IgG2b
- Specificity
- Human IRF6
- Species Reactivity
- Human
- Clone
- ZN106
- Applications
- Immunohistochemistry-Paraffin
- Conjugate
- Unconjugated
- Related Disease
- Popliteal Pterygium Syndrome and Orofacial Cleft 6
Product Property
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS (pH 7.3), 1% BSA, 50% glycerol
- Preservative
- 0.02% Sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Immunohistochemistry: 1/50-1/100
Target
- Alternative Names
- Interferon Regulatory Factor 6
- Gene ID
- 3664
- UniProt ID
- O14896
- Sequence Similarities
- Belongs to the IRF family.
- Cellular Localization
- Cytoplasm, Nucleus
- Post Translation Modifications
- Ubl conjugation
- Protein Refseq
- NP_001193625.1; NP_006138.1
- Function
- Probable DNA-binding transcriptional activator. Key determinant of the keratinocyte proliferation-differentiation switch involved in appropriate epidermal development (By similarity).
Plays a role in regulating mammary epithelial cell proliferation (By similarity).
May regulate WDR65 transcription (By similarity).
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "IRF6"
Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-1969-sdAb | Recombinant Anti-human IRF6 VHH Single Domain Antibody | ELISA, Neut, ICC, FC | Llama VHH |
| FAMAB-0332-CN-VHH | Camelid Anti-IRF6 Recombinant Single Domain Antibody (FAMAB-0332-CN-VHH) | ELISA | Camelid VHH |
| FAMAB-0333-CN-VHH | Camelid Anti-IRF6 Recombinant Single Domain Antibody (FAMAB-0333-CN-VHH) | ELISA | Camelid VHH |
| FAMAB-0334-CN-VHH | Camelid Anti-IRF6 Recombinant Single Domain Antibody (FAMAB-0334-CN-VHH) | ELISA | Camelid VHH |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| DrMAB-356 | Recombinant Human Anti-Human IRF6 Antibody, clone U69 | IP, IF | IgG |
| MRO-0872-CN | Recombinant Rabbit Anti-IRF6 Monoclonal Antibody (CBACN-324) | WB, IF, IHC | Rabbit IgG |
| VS3-CJ130 | Rabbit Anti-IRF6 Recombinant Antibody (VS3-CJ130) | WB, ICC, IF, IHC | Rabbit IgG |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1858 | Hi-Affi™ Recombinant Rabbit Anti-IRF6 Monoclonal Antibody (DS1858AB) | WB, IHC-P, ICC/IF | IgG |
MHC Tetramer for Cancer
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC1956 | PE-A2/Human IRF6 (GLYPGLIWL) MHC Tetramer | FCM | |
| MHC-LC1983 | PE-A*02:01/Human IRF6 (GLYPGLIWL) MHC Tetramer | FCM |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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