Mouse Anti-IRF6 Recombinant Antibody (clone ZN106)
CAT#: VS3-FY1584
This is a pathological recombinant antibody, which is a mouse IgG2b antibody. It exhibits high specificity and affinity for human IRF6. It can work in immunohistochemistry assay. The following concentration ranges are recommended starting points for this product: immunohistochemistry with a dilution of 1/50-1/100.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line HaCaT
Immunofluorescent staining of human cell line HaCaT shows localization to nucleoplasm, cytosol & cell junctions.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/63121/1576_F9_2_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm & cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/63121/1685_F8_1_blue_red_green.jpg
Normal Tissue
Figure 3 Cerebral cortex
Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
Glial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Nuclear
Neuronal cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/63121/154587_B_9_5.jpg
Normal Tissue
Figure 4 Colon
Glandular cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/63121/154587_A_9_3.jpg
Normal Tissue
Figure 5 Liver
Hepatocytes
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Nuclear
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/63121/154587_A_7_4.jpg
Normal Tissue
Figure 6 Kidney
Cells in tubules
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/63121/154587_A_8_5.jpg
Normal Tissue
Figure 7 Testis
Spermatogonia cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/63121/154587_A_6_6.jpg
Normal Tissue
Figure 8 Skin
Epidermal cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranousnucl ear
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/63121/154587_B_5_8.jpg
RNA Expression
Figure 9 RNA cell line category: Cell line enhanced (A-431, HaCaT, HBEC3-KT, hTCEpi, hTERT-HME1, RT4)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000117595-IRF6
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Specifications
- Host Species
- Mouse
- Type
- Mouse IgG2b
- Specificity
- Human IRF6
- Species Reactivity
- Human
- Clone
- ZN106
- Applications
- Immunohistochemistry-Paraffin
- Conjugate
- Unconjugated
- Related Disease
- Popliteal Pterygium Syndrome and Orofacial Cleft 6
Product Property
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS (pH 7.3), 1% BSA, 50% glycerol
- Preservative
- 0.02% Sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Immunohistochemistry: 1/50-1/100
Target
- Alternative Names
- Interferon Regulatory Factor 6
- Gene ID
- 3664
- UniProt ID
- O14896
- Sequence Similarities
- Belongs to the IRF family.
- Cellular Localization
- Cytoplasm, Nucleus
- Post Translation Modifications
- Ubl conjugation
- Protein Refseq
- NP_001193625.1; NP_006138.1
- Function
- Probable DNA-binding transcriptional activator. Key determinant of the keratinocyte proliferation-differentiation switch involved in appropriate epidermal development (By similarity).
Plays a role in regulating mammary epithelial cell proliferation (By similarity).
May regulate WDR65 transcription (By similarity).
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "IRF6"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-1969-sdAb | Recombinant Anti-human IRF6 VHH Single Domain Antibody | ELISA, Neut, ICC, FC | Llama VHH |
| FAMAB-0332-CN-VHH | Camelid Anti-IRF6 Recombinant Single Domain Antibody (FAMAB-0332-CN-VHH) | ELISA | Camelid VHH |
| FAMAB-0333-CN-VHH | Camelid Anti-IRF6 Recombinant Single Domain Antibody (FAMAB-0333-CN-VHH) | ELISA | Camelid VHH |
| FAMAB-0334-CN-VHH | Camelid Anti-IRF6 Recombinant Single Domain Antibody (FAMAB-0334-CN-VHH) | ELISA | Camelid VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| DrMAB-356 | Recombinant Human Anti-Human IRF6 Antibody, clone U69 | IP, IF | IgG |
| MRO-0872-CN | Recombinant Rabbit Anti-IRF6 Monoclonal Antibody (CBACN-324) | WB, IF, IHC | Rabbit IgG |
| VS3-CJ130 | Rabbit Anti-IRF6 Recombinant Antibody (VS3-CJ130) | WB, ICC, IF, IHC | Rabbit IgG |
| VS-0625-FY1436 | Human Anti-IRF6 Recombinant Antibody (clone 2506W1331) | ELISA, Spiked IP, IF | Human IgG1 |
| VS-0625-FY1437 | Human Anti-IRF6 Recombinant Antibody (clone 2506W1332) | Spiked IP, IF | Human IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1858 | Hi-Affi™ Recombinant Rabbit Anti-IRF6 Monoclonal Antibody (DS1858AB) | WB, IHC-P, ICC, IF | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC1956 | PE-A2/Human IRF6 (GLYPGLIWL) MHC Tetramer | FCM | |
| MHC-LC1983 | PE-A*02:01/Human IRF6 (GLYPGLIWL) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1147 | Anti-IRF6 Immunohistochemistry Kit | IHC | |
| VS-0525-XY3594 | Anti-Mouse IRF6 Immunohistochemistry Kit | IHC | |
| VS-0525-XY3593 | Anti-Human IRF6 Immunohistochemistry Kit | IHC |
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