PE-B*53:01/Human PMEL (LPDGQVIWV) MHC Tetramer (CAT#: MHC-LC2488)

• Allele
• B*53:01

• Class
• Class I

• MHC Species
• Human

• Antigen
• PMEL

• Antigen Species
• Human

• Peptide
• LPDGQVIWV

• Range
• 97-105

• Conjugate
• PE

• Application
• FCM

• Antigen Introduction
• This gene encodes a melanocyte-specific type I transmembrane glycoprotein. The encoded protein is enriched in melanosomes, which are the melanin-producing organelles in melanocytes, and plays an essential role in the structural organization of premelanosomes. This protein is involved in generating internal matrix fibers that define the transition from Stage I to Stage II melanosomes. This protein undergoes a complex pattern of prosttranslational processing and modification that is essential to the proper functioning of the protein. A secreted form of this protein that is released by proteolytic ectodomain shedding may be used as a melanoma-specific serum marker. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2011]

• Alternative Names
• PMEL; Melanocyte protein Pmel 17 precursor; P1; SI; SIL; ME20; P100; SILV; ME20M; gp100; ME20-M; PMEL17; D12S53E

• Gene ID
• 6490

• UniProt ID
• P40967

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