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PE-H-2Db/Human gp100 (KVPRNQDWL) MHC Tetramer (CAT#: MHC-LC201)

This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of Human gp100-derived peptide of KVPRNQDWL sequence covering 25-33 and H-2Db molecule. The pMHC tetramer recognizes mouse CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.


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  • Gene Expression
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Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line SK-MEL-30
Figure 1 IF staining of human cell line SK-MEL-30
(Immunofluorescent staining of human cell line SK-MEL-30 shows localization to endoplasmic reticulum & the Golgi apparatus.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/31649/1898_C6_19_cr5ba8a6f6e250d_selected.jpg
Normal Tissue
Figure 2 Kidney
Figure 2 Kidney
(Cells in tubules
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/31649/144626_A_7_5.jpg
Figure 3 Testis
Figure 3 Testis
(Leydig cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/31649/144626_A_4_6.jpg
Figure 4 Skin
Figure 4 Skin
(Melanocytes
Staining:High
Intensity: Strong
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/31649/144626_B_7_1.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enriched (SK-MEL-30)
Figure 5 RNA cell line category: Cell line enriched (SK-MEL-30)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000185664-PMEL

Specifications

  • Allele
  • H-2Db
  • Class
  • Class I
  • Antigen
  • Human gp100
  • Antigen Species
  • Human
  • Peptide
  • KVPRNQDWL
  • Range
  • 25-33
  • Conjugate
  • PE
  • Application
  • FCM

Target

  • Antigen Introduction
  • This gene encodes a melanocyte-specific type I transmembrane glycoprotein. The encoded protein is enriched in melanosomes, which are the melanin-producing organelles in melanocytes, and plays an essential role in the structural organization of premelanosomes. This protein is involved in generating internal matrix fibers that define the transition from Stage I to Stage II melanosomes. This protein undergoes a complex pattern of prosttranslational processing and modification that is essential to the proper functioning of the protein. A secreted form of this protein that is released by proteolytic ectodomain shedding may be used as a melanoma-specific serum marker. Alternate splicing results in multiple transcript variants.
  • Alternative Names
  • PMEL; premelanosome protein; P1; SI; SIL; ME20; P100; SILV; ME20M; gp100; ME20-M; PMEL17; D12S53E

Downloads

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Recombinant Antibody

CAT Product Name Application Type
MOB-1280z Mouse Anti-PMEL Recombinant Antibody (clone 21C9) ICC, IF, IHC Mouse IgG1
MOB-0325MZ Recombinant Mouse Anti-Human PMEL Antibody (clone IMB46) IHC Mouse antibody
HPAB-0046-LSX Mouse Anti-PMEL Recombinant Antibody (HPAB-0046-LSX) ELISA, WB, FC, IB, IF Mouse Fab
HPAB-0047-LSX Human Anti-PMEL Recombinant Antibody (HPAB-0047-LSX) ELISA, WB, FC Human IgG
ZG-0592F Mouse Anti-PMEL Recombinant Antibody (clone HMB45) IHC-P Mouse IgG1

Immunotoxin

CAT Product Name Application Type
AGTO-G051E Anti-PMEL immunotoxin (Fab)-PE Cytotoxicity assay, Function study

Mouse Antibody

CAT Product Name Application Type
TAB-1047CL-S(P) Anti-Human PMEL Recombinant Antibody scFv Fragment (A3F) IHC, WB, FC
TAB-1048CL-S(P) Anti-Human PMEL Recombinant Antibody scFv Fragment (G11B) IHC, WB, FC
TAB-1049CL-S(P) Anti-Human PMEL Recombinant Antibody scFv Fragment (J7E) IHC, WB, FC
TAB-1050CL-S(P) Mouse Anti-PMEL Recombinant Antibody; scFv Fragment (TAB-1050CL-S(P)) FC Mouse scFv
TAB-1051CL-S(P) Mouse Anti-PMEL Recombinant Antibody; scFv Fragment (TAB-1051CL-S(P)) FC Mouse scFv

MHC Tetramer for Cancer

CAT Product Name Application Type
MHC-LC141 PE-A*02:01/Human gp100 (YLEPGPVTA) MHC Tetramer FCM
MHC-LC142 APC-A*02:01/Human gp100 (YLEPGPVTA) MHC Tetramer FCM
MHC-LC153 PE-A*24:02/Human gp100-intron 4 (VYFFLPDHL) MHC Tetramer FCM
MHC-LC154 APC-A*24:02/Human gp100-intron 4 (VYFFLPDHL) MHC Tetramer FCM
MHC-LC202 APC-H-2Db/Human gp100 (KVPRNQDWL) MHC Tetramer FCM

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-2761 Hi-Affi™ Recombinant Rabbit Anti-PMEL Monoclonal Antibody (DS2761AB) IHC-P IgG

scFv Fragment Antibody

CAT Product Name Application Type
HPAB-0046-LSX-S(P) Mouse Anti-PMEL Recombinant Antibody; scFv Fragment (HPAB-0046-LSX-S(P)) ELISA, WB, FC Mouse scFv
HPAB-0047-LSX-S(P) Mouse Anti-PMEL Recombinant Antibody; scFv Fragment (HPAB-0047-LSX-S(P)) ELISA, WB, FC Mouse scFv

Fab Fragment Antibody

CAT Product Name Application Type
HPAB-0046-LSX-F(E) Mouse Anti-PMEL Recombinant Antibody; Fab Fragment (HPAB-0046-LSX-F(E)) ELISA, WB, FC Mouse Fab
HPAB-0047-LSX-F(E) Human Anti-PMEL Recombinant Antibody; Fab Fragment (HPAB-0047-LSX-F(E)) ELISA, WB, FC Chimeric Fab

MHC Tetramer for Virology

CAT Product Name Application Type
MHC-YF186 H-2Db/HPV16 E7 (RAHYNIVTF) MHC Monomer MHC Multimer
MHC-YF214 B*15:01/EBV EBNA4 (GQGGSPTAM) MHC Monomer MHC Multimer
MHC-YF225 A*02:01/HPV16 E7 (YMLDLQPET) MHC Monomer MHC Multimer
MHC-YF295 A*02:01/HPV E7 (YMLDLQPETT) MHC Monomer MHC Multimer

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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