Recombinant Chicken Anti-SynCAM (TSLC1/CADM1) IgY (3E1)
CAT#: BRD-0002MZ
This antibody is a recombinant chicken monoclonal antibody which specifically reacts with SynCAM (TSLC1/CADM1).
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to cell junctions.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/37266/if_selected.jpg
Normal Tissue
Figure 2 Epididymis
High expression
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/37266/158725_A_2_6_val_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Neuropil Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/37266/158725_B_8_5.jpg
Normal Tissue
Figure 4 Colon
Peripheral nerve/ganglion Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/37266/158725_A_8_3.jpg
Normal Tissue
Figure 5 Pancreas
Exocrine glandular cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Pancreatic endocrine cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/37266/158725_A_2_3.jpg
Normal Tissue
Figure 6 Kidney
Bowman's capsule Staining: High Intensity: Strong Quantity:>75% Collecting ducts Staining: Low Intensity: Moderate Quantity: <25% Distal tubules Staining: High Intensity: Strong Quantity:>75%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/37266/158725_A_7_5.jpg
Normal Tissue
Figure 7 Testis
Elongated or late spermatids Staining: Medium Intensity: Strong Quantity: <25% Sertoli cells Staining: High Intensity: Strong Quantity:>75%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/37266/158725_A_6_6.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced (CACO-2, WM-115)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000182985-CADM1
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Specifications
- Host Species
- Chicken
- Type
- Chicken antibody
- Species Reactivity
- Human, Mouse
- Clone
- 3E1
- Applications
- WB
Target
- Alternative Names
- CADM1; cell adhesion molecule 1; BL2; ST17; IGSF4; NECL2; RA175; TSLC1; IGSF4A; Necl-2; SYNCAM; sgIGSF; sTSLC-1; synCAM1; TSLC-1; nectin-like 2; nectin-like protein 2; truncated CADM1 protein; TSLC1/Nectin-like 2/IGSF4; synaptic cell adhesion molecule; tumor suppressor in lung cancer 1; immunoglobulin superfamily member 4; immunoglobulin superfamily, member 4; spermatogenic immunoglobulin superfamily; immunoglobulin superfamily, member 4D variant 1; immunoglobulin superfamily, member 4D variant 2
- Gene ID
- 23705
- UniProt ID
- Q9BY67
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Superior Reproducibility
The reproducibility of results using this antibody is outstanding. Whether it's used for tissue sections or cell lysates, the signal remains consistent and reliable. This is crucial for our multi-center study involving the detection of SNV NP across different environmental conditions. The antibody's performance facilitates data sharing and comparative analyses, supporting our collaborative efforts with accuracy.
Excellent Technical Support
Beyond the product quality, I have to commend the excellent technical support provided by Creative Biolabs. The team helped troubleshoot initial setup challenges swiftly, ensuring our project timelines were met. It's rare to find such dedicated support for research products, and it has truly made a difference in our workflow efficiency and overall user experience.
Enhanced Lab Efficiency
The dependability of the Anti-SNV NP antibody has streamlined our lab workflows significantly. Knowing that we can trust the results it provides means we spend less time on verification and more time pushing forward with critical research questions. The reduction in re-testing has saved both time and resources, boosting our efficiency and output.
Q&As
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How does SynCAM contribute to disease mechanisms?
A: SynCAM (also known as CADM1) plays a vital role in cell adhesion, impacting both neural development and tumor progression. It facilitates synapse formation in the brain while its dysregulation can lead to cancer metastasis, especially in lung and prostate cancers. Understanding SynCAM interactions aids in deciphering mechanisms that drive malignancy and neurodevelopmental disorders.
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How does SynCAM relate to specific disease pathways?
A: In cancer, SynCAM is involved in pathways regulating cell migration and adhesion, implicating its roles in metastatic spread. In the nervous system, it participates in pathways crucial for synapse organization and neuronal network formation. These pathways are vital for understanding therapeutic targets in both oncology and neurology.
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an this antibody contribute to cancer biomarker studies?
A: Yes, by detecting SynCAM expression in tumor tissues, the antibody aids in identifying cancer biomarkers related to cell adhesion and metastasis. This property is instrumental in developing potential diagnostic tools and targeted cancer therapies.
View the frequently asked questions answered by Creative Biolabs Support.
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Clone 3E1"
- CAT
- Product Name
See other products for "CADM1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3779z | Recombinant Anti-Human CADM1 Antibody | ELISA, WB, IP, FuncS | IgG |
| HPAB-1655-FY | Mouse Anti-CADM1 Recombinant Antibody (clone 035-029) | FC, ADCC | Mouse IgG |
| HPAB-1656-FY | Mouse Anti-CADM1 Recombinant Antibody (clone 035-212) | FC | Mouse IgG |
| HPAB-1657-FY | Mouse Anti-CADM1 Recombinant Antibody (clone 035-215) | FC | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3779z-F(E) | Recombinant Anti-Human CADM1 Antibody Fab Fragment | ELISA, FuncS | Fab |
| HPAB-1655-FY-S(P) | Mouse Anti-CADM1 Recombinant Antibody (clone 035-029); Fab Fragment | Cyt, IP | Mouse Fab |
| HPAB-1656-FY-S(P) | Mouse Anti-CADM1 Recombinant Antibody (clone 035-212); Fab Fragment | Cyt, IP | Mouse Fab |
| HPAB-1657-FY-S(P) | Mouse Anti-CADM1 Recombinant Antibody (clone 035-215); Fab Fragment | Cyt, IP | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3779z-S(P) | Recombinant Anti-Human CADM1 Antibody scFv Fragment | IP, IF, Biosensors, FuncS | scFv |
| HPAB-1655-FY-F(E) | Mouse Anti-CADM1 Recombinant Antibody (clone 035-029); scFv Fragment | Cyt, IP | Mouse scFv |
| HPAB-1656-FY-F(E) | Mouse Anti-CADM1 Recombinant Antibody (clone 035-212); scFv Fragment | Cyt, IP | Mouse scFv |
| HPAB-1657-FY-F(E) | Mouse Anti-CADM1 Recombinant Antibody (clone 035-215); scFv Fragment | Cyt, IP | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1444CL-S(P) | Anti-Human CADM1 Recombinant Antibody scFv Fragment (AB6) | ELISA | Fully human antibody |
| TAB-1445CL-S(P) | Anti-Human CADM1 Recombinant Antibody scFv Fragment (AB7) | ELISA | Fully human antibody |
| TAB-1446CL-S(P) | Anti-Human CADM1 Recombinant Antibody scFv Fragment (AB8) | ELISA | Fully human antibody |
| TAB-1447CL-S(P) | Anti-Human CADM1 Recombinant Antibody scFv Fragment (AB9) | ELISA | Fully human antibody |
| TAB-1448CL-S(P) | Anti-Human CADM1 Recombinant Antibody scFv Fragment (AB10) | IF, FC, WB, ELISA | Fully human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0003MZ | Recombinant Chicken Anti-SynCAM (TSLC1/CADM1) IgY-PE (3E1) | FC | Chicken antibody |
| BRD-0004MZ | Recombinant Chicken Anti-SynCAM (TSLC1/CADM1) IgY-FITC (3E1) | FC | Chicken antibody |
| BRD-0005MZ | Recombinant Chicken Anti-SynCAM (TSLC1/CADM1) IgY-Biotin (3E1) | FC | Chicken antibody |
| BRD-0007MZ | Recombinant Chicken Anti-SynCAM (TSLC1/CADM1) IgY (9D2) | FC | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0125-FY54 | Human Anti-CADM1 (clone 035-215) scFv-Fc Chimera | FC | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC247 | Recombinant Anti-CADM1 Vesicular Antibody, EV Displayed (VS-0425-YC247) | ELISA, FC, Cell-uptake |
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