Human Anti-CADM1 (clone 035-215) scFv-Fc Chimera (CAT#: VS-0125-FY54)
The Anti-CADM1 scFv-Fc is a recombinant single-chain variable fragment (scFv) fused to a fragment crystallizable (Fc) domain of an immunoglobulin. This innovative product is designed to specifically bind CADM1, a type 1 membrane protein involved in cell adhesion processes. CADM1 plays a crucial role in various biological functions, including synaptic plasticity, immune responses, and cellular interactions in different tissues.
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to cell junctions.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/37266/if_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to cell junctions.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/37266/if_selected.jpg
Figure 2 Epididymis
(High expression)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/37266/158725_A_2_6_val_selected.jpg
(High expression)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/37266/158725_A_2_6_val_selected.jpg
Figure 3 Cerebral cortex
(Neuropil Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/37266/158725_B_8_5.jpg
(Neuropil Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/37266/158725_B_8_5.jpg
Figure 4 Colon
(Peripheral nerve/ganglion Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/37266/158725_A_8_3.jpg
(Peripheral nerve/ganglion Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/37266/158725_A_8_3.jpg
Figure 5 Pancreas
(Exocrine glandular cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Pancreatic endocrine cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/37266/158725_A_2_3.jpg
(Exocrine glandular cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Pancreatic endocrine cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/37266/158725_A_2_3.jpg
Figure 6 Kidney
(Bowman's capsule Staining: High Intensity: Strong Quantity:>75% Collecting ducts Staining: Low Intensity: Moderate Quantity: <25% Distal tubules Staining: High Intensity: Strong Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/37266/158725_A_7_5.jpg
(Bowman's capsule Staining: High Intensity: Strong Quantity:>75% Collecting ducts Staining: Low Intensity: Moderate Quantity: <25% Distal tubules Staining: High Intensity: Strong Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/37266/158725_A_7_5.jpg
Figure 7 Testis
(Elongated or late spermatids Staining: Medium Intensity: Strong Quantity: <25% Sertoli cells Staining: High Intensity: Strong Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/37266/158725_A_6_6.jpg
(Elongated or late spermatids Staining: Medium Intensity: Strong Quantity: <25% Sertoli cells Staining: High Intensity: Strong Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/37266/158725_A_6_6.jpg
Figure 8 RNA cell line category: Cell line enhanced (CACO-2, WM-115)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000182985-CADM1
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000182985-CADM1
Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Species Reactivity
- Human
- Clone
- 035-215
- Applications
- Flow Cytometry
- Related Disease
- Small-cell lung cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Stabilizer
- No Stabilizers
- Sterility
- 0.2 μM filtered
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The function of these antibodies may be to promote the activation of Jurkat T cells in vitro to induce cell death in human small cell lung cancer (SCLC) cell lines such as NCI-H69, NCI-H146, and NCI-H187.
Target
- Alternative Names
- Cell Adhesion Molecule 1; Tumor Suppressor In Lung Cancer 1; Spermatogenic Immunoglobulin Superfamily; Immunoglobulin Superfamily Member 4; Synaptic Cell Adhesion Molecule; Nectin-Like Protein 2; Nectin-Like 2; Necl-2; SgIGSF; IGSF4A; SYNCAM; TSLC-1; IGSF4
- Gene ID
- 23705
- UniProt ID
- Q9BY67
- Sequence Similarities
- Belongs to the nectin family.
- Cellular Localization
- Cell membrane; Single-pass type I membrane protein
Synapse
- Post Translation Modifications
- Glycosylation at Asn-67 and Asn-101 promotes adhesive binding and synapse induction.
Glycosylation at Asn67, Asn101, Asn113, Asn165, Asn304, and Asn308
Modification sites at PhosphoSitePlus
Glycosylation from GlyConnect CADM1_HUMAN (1101)
Glycosylation from GlyGen 13 sites, 47 N-linked glycans (6 sites), 1 O-linked glycan (1 site)
- Protein Refseq
- XP_005271551.1; XP_016872946.1; XP_047282646.1; XP_047282647.1; XP_047282648.1
- Function
- Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner.
Also mediates heterophilic cell-cell adhesion with CADM3 and NECTIN3 in a Ca(2+)-independent manner (By similarity).
Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM1 in vivo.
In mast cells, may mediate attachment to and promote communication with nerves.
CADM1, together with MITF, is essential for development and survival of mast cells in vivo.
By interacting with CRTAM and thus promoting the adhesion between CD8+ T-cells and CD8+ dendritic cells, regulates the retention of activated CD8+ T-cell within the draining lymph node (By similarity).
Recommended Products
Secondary Antibody
Isotype Control
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3779z | Recombinant Anti-Human CADM1 Antibody | ELISA, WB, IP, FuncS | IgG |
| HPAB-1655-FY | Mouse Anti-CADM1 Recombinant Antibody (clone 035-029) | FC, ADCC | Mouse IgG |
| HPAB-1656-FY | Mouse Anti-CADM1 Recombinant Antibody (clone 035-212) | FC | Mouse IgG |
| HPAB-1657-FY | Mouse Anti-CADM1 Recombinant Antibody (clone 035-215) | FC | Mouse IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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