Anti-Human CADM1 Recombinant Antibody (AB4)
CAT#: TAB-1442CL
This anitbody that specifically binds to CADM1 can be used in the treatment and diagnosis of cancer, including melanoma, colon and/or colorectal cancer or prostate cancer.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to cell junctions.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/37266/if_selected.jpg
Normal Tissue
Figure 2 Epididymis
High expression
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/37266/158725_A_2_6_val_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Neuropil Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/37266/158725_B_8_5.jpg
Normal Tissue
Figure 4 Colon
Peripheral nerve/ganglion Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/37266/158725_A_8_3.jpg
Normal Tissue
Figure 5 Pancreas
Exocrine glandular cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Pancreatic endocrine cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/37266/158725_A_2_3.jpg
Normal Tissue
Figure 6 Kidney
Bowman's capsule Staining: High Intensity: Strong Quantity:>75% Collecting ducts Staining: Low Intensity: Moderate Quantity: <25% Distal tubules Staining: High Intensity: Strong Quantity:>75%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/37266/158725_A_7_5.jpg
Normal Tissue
Figure 7 Testis
Elongated or late spermatids Staining: Medium Intensity: Strong Quantity: <25% Sertoli cells Staining: High Intensity: Strong Quantity:>75%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/37266/158725_A_6_6.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced (CACO-2, WM-115)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000182985-CADM1
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Specifications
- Host Species
- Human
- Type
- Fully human antibody
- Specificity
- Human
- Clone
- AB4
- Related Disease
- Cancer (such as melanoma, colon and/or colorectal cancer or prostate cancer)
Target
- Alternative Names
- CADM1; cell adhesion molecule 1; BL2; ST17; IGSF4; NECL2; RA175; TSLC1; IGSF4A; Necl-2; SYNCAM; sgIGSF; sTSLC-1; synCAM1; TSLC-1; nectin-like 2; nectin-like protein 2; truncated CADM1 protein; TSLC1/Nectin-like 2/IGSF4; synaptic cell adhesion molecule; tumor suppressor in lung cancer 1; immunoglobulin superfamily member 4; immunoglobulin superfamily, member 4; spermatogenic immunoglobulin superfamily; immunoglobulin superfamily, member 4D variant 1; immunoglobulin superfamily, member 4D variant 2
- Gene ID
- 23705
- UniProt ID
- Q9BY67
REVIEWS AND Q&AS
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Useful For Cancer Marker Studies
We are investigating CADM1 as a tumor suppressor in lung and colorectal cancer models. This recombinant human antibody (Clone AB4) specifically binds to CADM1 and has been very useful in our ELISA assays. It helps us monitor the expression of this cell adhesion molecule in various cell lines.
Fully Human Antibody Reagent
The fact that this is a fully human antibody is advantageous for our specific experimental setup. We found it to be highly specific for the target, facilitating our research into cell adhesion mechanisms. It has shown good stability when stored at -20°C.
Q&As
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Is this a fully human antibody?
A: Yes, this is a Fully Human recombinant antibody (Clone AB4). It specifically binds to Human CADM1 (Cell adhesion molecule 1). It is suitable for use in ELISA and potentially for research involving cancer diagnosis.
-
What is the relevance of the target CADM1?
A: CADM1 is a cell adhesion molecule that acts as a tumor suppressor in lung cancer (TSLC1) and is involved in cell-cell adhesion. It is often downregulated in various cancers, including melanoma and colorectal cancer. This antibody can be used to study these pathways.
View the frequently asked questions answered by Creative Biolabs Support.
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Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Clone AB4"
- CAT
- Product Name
See other products for "CADM1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3779z | Recombinant Anti-Human CADM1 Antibody | ELISA, WB, IP, FuncS | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3779z-F(E) | Recombinant Anti-Human CADM1 Antibody Fab Fragment | ELISA, FuncS | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3779z-S(P) | Recombinant Anti-Human CADM1 Antibody scFv Fragment | IP, IF, Biosensors, FuncS | scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1439CL | Anti-Human CADM1 Recombinant Antibody (AB1) | ELISA | Fully human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1440CL | Anti-Human CADM1 Recombinant Antibody (AB2) | FC | Fully human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1441CL | Anti-Human CADM1 Recombinant Antibody (AB3) | FC | Fully human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1443CL | Anti-Human CADM1 Recombinant Antibody (AB5) | ELISA | Fully human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1444CL | Anti-Human CADM1 Recombinant Antibody (AB6) | ELISA | Fully human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0002MZ | Recombinant Chicken Anti-SynCAM (TSLC1/CADM1) IgY (BRD-0002MZ) | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0003MZ | Recombinant Chicken Anti-SynCAM (TSLC1/CADM1) IgY-PE (BRD-0003MZ) | FC | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0004MZ | Recombinant Chicken Anti-SynCAM (TSLC1/CADM1) IgY-FITC (BRD-0004MZ) | FC | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0005MZ | Recombinant Chicken Anti-SynCAM (TSLC1/CADM1) IgY-Biotin (BRD-0005MZ) | FC | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0007MZ | Recombinant Chicken Anti-SynCAM (TSLC1/CADM1) IgY (BRD-0007MZ) | FC | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1655-FY | Mouse Anti-CADM1 Recombinant Antibody (clone 035-029) | FC, ADCC | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1656-FY | Mouse Anti-CADM1 Recombinant Antibody (clone 035-212) | FC | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1657-FY | Mouse Anti-CADM1 Recombinant Antibody (clone 035-215) | FC | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1655-FY-F(E) | Mouse Anti-CADM1 Recombinant Antibody (clone 035-029); scFv Fragment | Cyt, IP | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1656-FY-F(E) | Mouse Anti-CADM1 Recombinant Antibody (clone 035-212); scFv Fragment | Cyt, IP | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1657-FY-F(E) | Mouse Anti-CADM1 Recombinant Antibody (clone 035-215); scFv Fragment | Cyt, IP | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1655-FY-S(P) | Mouse Anti-CADM1 Recombinant Antibody (clone 035-029); Fab Fragment | Cyt, IP | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1656-FY-S(P) | Mouse Anti-CADM1 Recombinant Antibody (clone 035-212); Fab Fragment | Cyt, IP | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1657-FY-S(P) | Mouse Anti-CADM1 Recombinant Antibody (clone 035-215); Fab Fragment | Cyt, IP | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0125-FY54 | Human Anti-CADM1 (clone 035-215) scFv-Fc Chimera | FC | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC247 | Recombinant Anti-CADM1 Vesicular Antibody, EV Displayed (VS-0425-YC247) | ELISA, FC, Cell-uptake |
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