Is this a fully human antibody?

Yes, this is a Fully Human recombinant antibody (Clone AB4). It specifically binds to Human CADM1 (Cell adhesion molecule 1). It is suitable for use in ELISA and potentially for research involving cancer diagnosis.

What is the relevance of the target CADM1?

CADM1 is a cell adhesion molecule that acts as a tumor suppressor in lung cancer (TSLC1) and is involved in cell-cell adhesion. It is often downregulated in various cancers, including melanoma and colorectal cancer. This antibody can be used to study these pathways.

Anti-Human CADM1 Recombinant Antibody (AB4)

CAT#: TAB-1442CL

This anitbody that specifically binds to CADM1 can be used in the treatment and diagnosis of cancer, including melanoma, colon and/or colorectal cancer or prostate cancer.

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line U-2 OS

Immunofluorescent staining of human cell line U-2 OS shows localization to cell junctions.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/37266/if_selected.jpg

Normal Tissue Figure 2 Epididymis

High expression

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/37266/158725_A_2_6_val_selected.jpg

Normal Tissue Figure 3 Cerebral cortex

Neuropil Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/37266/158725_B_8_5.jpg

Normal Tissue Figure 4 Colon

Peripheral nerve/ganglion Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/37266/158725_A_8_3.jpg

Normal Tissue Figure 5 Pancreas

Exocrine glandular cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Pancreatic endocrine cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/37266/158725_A_2_3.jpg

Normal Tissue Figure 6 Kidney

Bowman's capsule Staining: High Intensity: Strong Quantity:>75% Collecting ducts Staining: Low Intensity: Moderate Quantity: <25% Distal tubules Staining: High Intensity: Strong Quantity:>75%

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/37266/158725_A_7_5.jpg

Normal Tissue Figure 7 Testis

Elongated or late spermatids Staining: Medium Intensity: Strong Quantity: <25% Sertoli cells Staining: High Intensity: Strong Quantity:>75%

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/37266/158725_A_6_6.jpg

RNA Expression Figure 8 RNA cell line category: Cell line enhanced (CACO-2, WM-115)

Cell lines ordered by descending RNA expression order

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000182985-CADM1

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Specifications

Host Species
Human

Type
Fully human antibody

Specificity
Human

Clone
AB4

Related Disease
Cancer (such as melanoma, colon and/or colorectal cancer or prostate cancer)

Target

Alternative Names
CADM1; cell adhesion molecule 1; BL2; ST17; IGSF4; NECL2; RA175; TSLC1; IGSF4A; Necl-2; SYNCAM; sgIGSF; sTSLC-1; synCAM1; TSLC-1; nectin-like 2; nectin-like protein 2; truncated CADM1 protein; TSLC1/Nectin-like 2/IGSF4; synaptic cell adhesion molecule; tumor suppressor in lung cancer 1; immunoglobulin superfamily member 4; immunoglobulin superfamily, member 4; spermatogenic immunoglobulin superfamily; immunoglobulin superfamily, member 4D variant 1; immunoglobulin superfamily, member 4D variant 2

Gene ID
23705

UniProt ID
Q9BY67

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Breast cancer biomarkers at key points during disease progression

Useful For Cancer Marker Studies

We are investigating CADM1 as a tumor suppressor in lung and colorectal cancer models. This recombinant human antibody (Clone AB4) specifically binds to CADM1 and has been very useful in our ELISA assays. It helps us monitor the expression of this cell adhesion molecule in various cell lines.

Fully Human Antibody Reagent

The fact that this is a fully human antibody is advantageous for our specific experimental setup. We found it to be highly specific for the target, facilitating our research into cell adhesion mechanisms. It has shown good stability when stored at -20°C.

Q&As

Is this a fully human antibody?

A: Yes, this is a Fully Human recombinant antibody (Clone AB4). It specifically binds to Human CADM1 (Cell adhesion molecule 1). It is suitable for use in ELISA and potentially for research involving cancer diagnosis.
What is the relevance of the target CADM1?

A: CADM1 is a cell adhesion molecule that acts as a tumor suppressor in lung cancer (TSLC1) and is involved in cell-cell adhesion. It is often downregulated in various cancers, including melanoma and colorectal cancer. This antibody can be used to study these pathways.

View the frequently asked questions answered by Creative Biolabs Support.

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Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - TAB-1442CL.pdf

MSDS

MSDS - TAB-1442CL.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

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CAT
Product Name

See other products for "CADM1"

Select a product category from the dropdown menu below to view related products.

CAT	Product Name	Application	Type
MOB-3779z	Recombinant Anti-Human CADM1 Antibody	ELISA, WB, IP, FuncS	IgG

CAT	Product Name	Application	Type
MOB-3779z-F(E)	Recombinant Anti-Human CADM1 Antibody Fab Fragment	ELISA, FuncS	Fab

CAT	Product Name	Application	Type
MOB-3779z-S(P)	Recombinant Anti-Human CADM1 Antibody scFv Fragment	IP, IF, Biosensors, FuncS	scFv

CAT	Product Name	Application	Type
TAB-1439CL	Anti-Human CADM1 Recombinant Antibody (AB1)	ELISA	Fully human antibody

CAT	Product Name	Application	Type
TAB-1440CL	Anti-Human CADM1 Recombinant Antibody (AB2)	FC	Fully human antibody

CAT	Product Name	Application	Type
TAB-1441CL	Anti-Human CADM1 Recombinant Antibody (AB3)	FC	Fully human antibody

CAT	Product Name	Application	Type
TAB-1443CL	Anti-Human CADM1 Recombinant Antibody (AB5)	ELISA	Fully human antibody

CAT	Product Name	Application	Type
TAB-1444CL	Anti-Human CADM1 Recombinant Antibody (AB6)	ELISA	Fully human antibody

CAT	Product Name	Application	Type
BRD-0002MZ	Recombinant Chicken Anti-SynCAM (TSLC1/CADM1) IgY (BRD-0002MZ)	WB	Chicken antibody

CAT	Product Name	Application	Type
BRD-0003MZ	Recombinant Chicken Anti-SynCAM (TSLC1/CADM1) IgY-PE (BRD-0003MZ)	FC	Chicken antibody

CAT	Product Name	Application	Type
BRD-0004MZ	Recombinant Chicken Anti-SynCAM (TSLC1/CADM1) IgY-FITC (BRD-0004MZ)	FC	Chicken antibody

CAT	Product Name	Application	Type
BRD-0005MZ	Recombinant Chicken Anti-SynCAM (TSLC1/CADM1) IgY-Biotin (BRD-0005MZ)	FC	Chicken antibody

CAT	Product Name	Application	Type
BRD-0007MZ	Recombinant Chicken Anti-SynCAM (TSLC1/CADM1) IgY (BRD-0007MZ)	FC	Chicken antibody

CAT	Product Name	Application	Type
HPAB-1655-FY	Mouse Anti-CADM1 Recombinant Antibody (clone 035-029)	FC, ADCC	Mouse IgG

CAT	Product Name	Application	Type
HPAB-1656-FY	Mouse Anti-CADM1 Recombinant Antibody (clone 035-212)	FC	Mouse IgG

CAT	Product Name	Application	Type
HPAB-1657-FY	Mouse Anti-CADM1 Recombinant Antibody (clone 035-215)	FC	Mouse IgG

CAT	Product Name	Application	Type
HPAB-1655-FY-F(E)	Mouse Anti-CADM1 Recombinant Antibody (clone 035-029); scFv Fragment	Cyt, IP	Mouse scFv

CAT	Product Name	Application	Type
HPAB-1656-FY-F(E)	Mouse Anti-CADM1 Recombinant Antibody (clone 035-212); scFv Fragment	Cyt, IP	Mouse scFv

CAT	Product Name	Application	Type
HPAB-1657-FY-F(E)	Mouse Anti-CADM1 Recombinant Antibody (clone 035-215); scFv Fragment	Cyt, IP	Mouse scFv

CAT	Product Name	Application	Type
HPAB-1655-FY-S(P)	Mouse Anti-CADM1 Recombinant Antibody (clone 035-029); Fab Fragment	Cyt, IP	Mouse Fab

CAT	Product Name	Application	Type
HPAB-1656-FY-S(P)	Mouse Anti-CADM1 Recombinant Antibody (clone 035-212); Fab Fragment	Cyt, IP	Mouse Fab

CAT	Product Name	Application	Type
HPAB-1657-FY-S(P)	Mouse Anti-CADM1 Recombinant Antibody (clone 035-215); Fab Fragment	Cyt, IP	Mouse Fab

CAT	Product Name	Application	Type
VS-0125-FY54	Human Anti-CADM1 (clone 035-215) scFv-Fc Chimera	FC	Human IgG1, scFv-Fc

CAT	Product Name	Application	Type
VS-0425-YC247	Recombinant Anti-CADM1 Vesicular Antibody, EV Displayed (VS-0425-YC247)	ELISA, FC, Cell-uptake

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