Recombinant Human Anti-human LY75 Antibody (CAT#: MHH-637)
Recombinant Human Antibody is against Human LY75, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-LY75 mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-LY75 mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition.
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Subcellular Location and Protein Expression
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line
(Immunofluorescent staining of human cell line CACO-2 shows localization to the Golgi apparatus.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/54073/if_selected.jpg
(Immunofluorescent staining of human cell line CACO-2 shows localization to the Golgi apparatus.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/54073/if_selected.jpg
Figure 2 IHC staining of human colon
(Immunohistochemical staining of human colon shows moderate cytoplasmic positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/49108/ihc_selected.jpg
(Immunohistochemical staining of human colon shows moderate cytoplasmic positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/49108/ihc_selected.jpg
Figure 3 IHC staining of human spleen
(High expression. RNA expression: 18.4 nTPM)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1450/ihc_selected.jpg
(High expression. RNA expression: 18.4 nTPM)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1450/ihc_selected.jpg
Figure 4 IHC staining of human skeletal muscle
(Low expression. RNA expression: 0.3 nTPM)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1450/4611_B_3_6_val_selected.jpg
(Low expression. RNA expression: 0.3 nTPM)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1450/4611_B_3_6_val_selected.jpg
Figure 5 Cerebral cortex
(Neuropil
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/49108/127068_B_8_5.jpg
(Neuropil
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/49108/127068_B_8_5.jpg
Figure 6 Liver
(Cholangiocytes
Staining: Low
Intensity: Weak
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1450/4611_A_9_4.jpg
(Cholangiocytes
Staining: Low
Intensity: Weak
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1450/4611_A_9_4.jpg
Figure 7 Kidney
(Cells in glomeruli
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Cells in tubules
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/49108/127068_A_8_5.jpg
(Cells in glomeruli
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Cells in tubules
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/49108/127068_A_8_5.jpg
Figure 8 Testis
(Elongated or late spermatids
Staining: Medium
Intensity: Moderate
Quantity:>75%
Leydig cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/49108/127068_A_5_6.jpg
(Elongated or late spermatids
Staining: Medium
Intensity: Moderate
Quantity:>75%
Leydig cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/49108/127068_A_5_6.jpg
Figure 9 Lymph node
(Germinal center cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1450/4611_A_7_8.jpg
(Germinal center cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/1450/4611_A_7_8.jpg
Figure 10 RNA cell line category: Cell line enhanced (CAPAN-2, HDLM-2, Karpas-707, RT4, THP-1)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000054219-LY75
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000054219-LY75
Specifications
- Immunogen
- Human lymphocyte antigen 75
- Host Species
- Human
- Derivation
- Human
- Type
- IgG
- Specificity
- Tested positive against native Human lymphocyte antigen 75
- Species Reactivity
- Human
- Applications
- Products can be used for: Western blot; Flow Cytometry; Functional Study
Product Property
- Purity
- >95%, by SDS-PAGE, under reducing conditions
- Storage
- Store at -20°C. Open under aseptic conditions.
Target
- Alternative Names
- LY75; lymphocyte antigen 75; CD205; LY-75; CLEC13B; DEC-205; GP200-MR6; C-type lectin domain family 13 member B
- Gene ID
- 4065
- UniProt ID
- O60449
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-637-F(E) | Recombinant Anti-human LY75 Antibody Fab Fragment | Neut, WB, FuncS | Fab |
| MHH-637-F(E) | Recombinant Human Anti-human LY75 Antibody Fab Fragment | ELISA, WB, IP, FuncS | Fab |
| HPAB-0432LY-F(E) | Human Anti-LY75 Recombinant Antibody; Fab Fragment (HPAB-0432LY-F(E)) | ELISA | Human Fab |
| HPAB-0470-YJ-F(E) | Mouse Anti-LY75 Recombinant Antibody; Fab Fragment (HPAB-0470-YJ-F(E)) | ELISA, IP, FuncS | Mouse Fab |
| HPAB-0471-YJ-F(E) | Mouse Anti-LY75 Recombinant Antibody; Fab Fragment (HPAB-0471-YJ-F(E)) | ELISA, IP, FuncS | Mouse Fab |
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