Recombinant Anti-LY75 Vesicular Antibody, EV Displayed (VS-0425-YC689)
CAT#: VS-0425-YC689
The Recombinant Anti-LY75 Vesicular Antibody, EV Displayed (VS-0425-YC689) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to LY75-expressed cells or tissues. LY75 enables signaling receptor activity and is involved in endocytosis, located on the plasma membrane, expressed in the liver and thymus, with multiple human orthologs.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line
Immunofluorescent staining of human cell line CACO-2 shows localization to the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/54073/if_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human colon
Immunohistochemical staining of human colon shows moderate cytoplasmic positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/49108/ihc_selected.jpg
Normal Tissue
Figure 3 IHC staining of human spleen
High expression. RNA expression: 18.4 nTPM
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1450/ihc_selected.jpg
Normal Tissue
Figure 4 IHC staining of human skeletal muscle
Low expression. RNA expression: 0.3 nTPM
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1450/4611_B_3_6_val_selected.jpg
Normal Tissue
Figure 5 Cerebral cortex
Neuropil
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/49108/127068_B_8_5.jpg
Normal Tissue
Figure 6 Liver
Cholangiocytes
Staining: Low
Intensity: Weak
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1450/4611_A_9_4.jpg
Normal Tissue
Figure 7 Kidney
Cells in glomeruli
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Cells in tubules
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/49108/127068_A_8_5.jpg
Normal Tissue
Figure 8 Testis
Elongated or late spermatids
Staining: Medium
Intensity: Moderate
Quantity:>75%
Leydig cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/49108/127068_A_5_6.jpg
Normal Tissue
Figure 9 Lymph node
Germinal center cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1450/4611_A_7_8.jpg
RNA Expression
Figure 10 RNA cell line category: Cell line enhanced (CAPAN-2, HDLM-2, Karpas-707, RT4, THP-1)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000054219-LY75
❮
❯
Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- LY75
- Host Animal
- Rat
- Antibody Isotype
- IgG
- Species Reactivity
- Mouse
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Lymphocyte antigen 75
- Biological Process
- Endocytosis
- Molecular Function
- Receptor
- Cellular Localization
- Golgi apparatus
- Introduction
- Predicted to enable signaling receptor activity. Predicted to be involved in endocytosis. Located in external side of plasma membrane. Is expressed in liver; thymus; and thymus primordium. Orthologous to several human genes including LY75 (lymphocyte antigen 75).
- Alternative Names
- CD205, DEC-205, DEC205
- Gene ID
- 17076
- UniProt ID
- A2AW86
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Datasheet
MSDS
COA
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See other products for "LY75"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-637 | Recombinant Human Anti-human LY75 Antibody | WB, FC, FuncS | IgG |
| HPAB-0432LY | Human Anti-LY75 Recombinant Antibody (HPAB-0432LY) | ELISA | Human IgG1 |
| HPAB-0433LY | Human Anti-LY75 Recombinant Antibody (HPAB-0433LY) | ELISA | Human IgG1 |
| FAMAB-1616CQ | Rat Anti-LY75 Recombinant Antibody (clone NLDC145) | IB, FC, IF, IHC | Rat IgG2a |
| VS3-FY259 | Recombinant Mouse Anti-LY75 Antibody (clone 4B10E11) | ELISA, FC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-637-S(P) | Recombinant Human Anti-human LY75 Antibody scFv Fragment | RIA, ELISA, FuncS | scFv |
| HPAB-0432LY-S(P) | Human Anti-LY75 Recombinant Antibody; scFv Fragment (HPAB-0432LY-S(P)) | ELISA | Human scfv |
| HPAB-0433LY-S(P) | Human Anti-LY75 Recombinant Antibody; scFv Fragment (HPAB-0433LY-S(P)) | ELISA | Human scfv |
| HPAB-0470-YJ-S(P) | Mouse Anti-LY75 Recombinant Antibody; scFv Fragment (HPAB-0470-YJ-S(P)) | ELISA, IP, FuncS | Mouse scFv |
| HPAB-0471-YJ-S(P) | Mouse Anti-LY75 Recombinant Antibody; scFv Fragment (HPAB-0471-YJ-S(P)) | ELISA, IP, FuncS | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2105 | Hi-Affi™ Recombinant Rabbit Anti-LY75 Monoclonal Antibody (DS2105AB) | IHC-P, IHC-Fr | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0432LY-F(E) | Human Anti-LY75 Recombinant Antibody; Fab Fragment (HPAB-0432LY-F(E)) | ELISA | Human Fab |
| HPAB-0433LY-F(E) | Human Anti-LY75 Recombinant Antibody; Fab Fragment (HPAB-0433LY-F(E)) | ELISA | Human Fab |
| HPAB-0434LY-F(E) | Human Anti-LY75 Recombinant Antibody; Fab Fragment (HPAB-0434LY-F(E)) | ELISA | Human Fab |
| HPAB-0470-YJ-F(E) | Mouse Anti-LY75 Recombinant Antibody; Fab Fragment (HPAB-0470-YJ-F(E)) | ELISA, IP, FuncS | Mouse Fab |
| HPAB-0471-YJ-F(E) | Mouse Anti-LY75 Recombinant Antibody; Fab Fragment (HPAB-0471-YJ-F(E)) | ELISA, IP, FuncS | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY196 | Human Anti-LY75 scFv-Fc Chimera (VS-0325-FY196) | ELISA, FC | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY4139 | Anti-LY75 Immunohistochemistry Kit | IHC | |
| VS-0525-XY4140 | Anti-Mouse LY75 Immunohistochemistry Kit | IHC |
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