Anti-CD21 (clone THB-5)-mc-vc-PABC-MMAE ADC
CAT#: ADC-191LZY
This ADC product is composed of an anti-CD21 antibody (clone THB-5 ) conjugated via mc-vc-PABC linker to MMAE (THB-5-mc-vc-PABC-MMAE). It has demonstrated a response in non-Hodgkin's lymphoma treatment by a MOA (Mechanism of Action) of microtubules depolymerizing.



Specifications
- Antibody Overview
- Mouse Anti-CD21 IgG2a,THB-5
- Clone
- THB-5
- Antibody Isotype
- IgG2a
- Linker
- mc-VC-PABC(maleimidocaproyl valine-citrulline-p-aminobenzyl carbamoyl)
- Linker Class/Description
- Class: Enzymatically cleavable linker-Peptide linker
Description: peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.
- Drug
- MMAE (monomethyl auristatin E)
- Drug Class/Description
- Class: Auristatin
Description: Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.
Target
- Introduction
- This gene encodes a membrane protein, which functions as a receptor for Epstein-Barr virus (EBV) binding on B and T lymphocytes. Genetic variations in this gene are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
- Alternative Names
- CR2; complement component (3d/Epstein Barr virus) receptor 2; CR; C3DR; CD21; CVID7; SLEB9; complement receptor type 2; EBV receptor; complement C3d receptor;
- Gene ID
- 1380
- UniProt ID
- P20023
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Datasheet
MSDS
COA
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