Anti-CD21 (clone THB-5)-MCC-DM1 ADC (CAT#: ADC-190LZY)

This ADC product is composed of an anti-CD21 antibody (clone THB-5 ) conjugated via MCC linker to DM1 (THB-5-MCC-DM1). It has demonstrated a response in non-Hodgkin's lymphoma treatment by a MOA (Mechanism of Action) of microtubules depolymerizing.


Specific Inquiry
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Normal Tissue
RNA Expression

Specifications

  • Antibody Overview
  • Mouse Anti-CD21 IgG2a,THB-5
  • Clone
  • THB-5
  • Antibody Isotype
  • IgG2a
  • Linker
  • MCC(Maleimidomethyl cyclohexane-1-carboxylate)
  • Linker Class/Description
  • Class: Noncleavable linker
    Description: Noncleavable linker is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation
  • Drug
  • DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
  • Drug Class/Description
  • Class: Maytansinoid
    Description: Maytansinoids are a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. The eponymous natural cytotoxic agent maytansine is a 19-member lactam (ansa
    macrolide) structure originally isolated from the Ethiopian shrub Maytenus ovatus. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells

Target

  • Introduction
  • This gene encodes a membrane protein, which functions as a receptor for Epstein-Barr virus (EBV) binding on B and T lymphocytes. Genetic variations in this gene are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
  • Alternative Names
  • CR2; complement component (3d/Epstein Barr virus) receptor 2; CR; C3DR; CD21; CVID7; SLEB9; complement receptor type 2; EBV receptor; complement C3d receptor;

Downloads

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Neutralizing Antibody

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Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-0795 Hi-Affi™ Rabbit Anti-CR2 Recombinant Antibody (clone DS795AB) ELISA Rabbit IgG

MHC Tetramer for Cancer

CAT Product Name Application Type
MHC-LC3372 PE-B*15:16/Human CR2 (VSYGSIVTY) MHC Tetramer FCM

Fab Fragment Antibody

CAT Product Name Application Type
FAMAB-0109JF-F(E) Mouse Anti-Cr2 Recombinant Antibody (clone 4B2); Fab Fragment FC, WB, ELISA, FuncS Mouse Fab

scFv Fragment Antibody

CAT Product Name Application Type
FAMAB-0109JF-S(P) Mouse Anti-Cr2 Recombinant Antibody (clone 4B2); scFv Fragment FC, WB, ELISA, FuncS Mouse scFv

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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