Anti-RON (clone Zt/g4)-SMCC-DM1 ADC
CAT#: ADC-228LZY
This ADC product is composed of an anti-RON antibody (clone Zt/g4) conjugated via SMCC linker to DM1 (Zt/g4-SMCC-DM1). It has demonstrated a response in Colorectal Cancer treatment by a MOA (Mechanism of Action) of microtubules depolymerizing.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8180/44_E6_1_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Glial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8180/22751_B_8_5.jpg
Normal Tissue
Figure 3 Colon
Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8180/22751_A_7_3.jpg
Normal Tissue
Figure 4 Liver
Cholangiocytes Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Hepatocytes Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8180/22751_A_7_4.jpg
Normal Tissue
Figure 5 Kidney
Cells in glomeruli Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8180/22751_A_9_5.jpg
Normal Tissue
Figure 6 Testis
Cells in seminiferous ducts Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8180/22751_A_6_6.jpg
Normal Tissue
Figure 7 Skin
Fibroblasts Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Keratinocytes Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Melanocytes Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8180/22751_B_8_1.jpg
Normal Tissue
Figure 8 Lymph node
Germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8180/22751_A_8_8.jpg
RNA Expression
Figure 9 RNA cell line category: Cell line enhanced (A-431, CAPAN-2, HaCaT, HBEC3-KT, hTCEpi, RT4)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000164078-MST1R
❮
❯
Specifications
- Antibody Overview
- Mouse Anti-RON IgG1a/κ,Zt/g4
- Clone
- Zt/g4
- Linker
- SMCC (4-[N-maleimidomethyl] cyclohexane-1 carboxylhydrazide).
- Linker Class/Description
- Class: Noncleavable linker
Description: Noncleavable linker is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation
- Drug
- DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
- Drug Class/Description
- Class: Maytansinoid
Description: Maytansinoids are a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. The eponymous natural cytotoxic agent maytansine is a 19-member lactam (ansa
macrolide) structure originally isolated from the Ethiopian shrub Maytenus ovatus. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells
Target
- Introduction
- This gene encodes a cell surface receptor for macrophage-stimulating protein (MSP) with tyrosine kinase activity. The mature form of this protein is a heterodimer of disulfide-linked alpha and beta subunits, generated by proteolytic cleavage of a single-chain precursor. The beta subunit undergoes tyrosine phosphorylation upon stimulation by MSP. This protein is expressed on the ciliated epithelia of the mucociliary transport apparatus of the lung, and together with MSP, thought to be involved in host defense. Alternatively spliced transcript variants encoding different isoforms with different structural and biochemical properties have been described (PMID:8816464). [provided by RefSeq, Oct 2011]
- Alternative Names
- MST1R; macrophage stimulating 1 receptor (c-met-related tyrosine kinase); RON; PTK8; CD136; CDw136; macrophage-stimulating protein receptor; p185-Ron; MSP receptor; RON variant 21; RON variant E2E3; MST1R variant RON30; MST1R variant RON62; soluble RON variant 1; soluble RON variant 2; soluble RON variant 3; soluble RON variant 4; c-met-related tyrosine kinase; PTK8 protein tyrosine kinase 8;
- Gene ID
- 4486
- UniProt ID
- B4E058
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for ADC-228LZY. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "MST1R"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-184 | Anti-Human RON Recombinant Antibody (Narnatumab) | FuncS, IF, Neut, ELISA, FC, IP, ICC | IgG1 - kappa |
| TAB-332CT | Anti-Human RON Recombinant Antibody (TAB-332CT) | WB, ELISA, FC | Human antibody |
| TAB-333CT | Human Anti-MST1R Recombinant Antibody (TAB-333CT) | WB, ELISA, FC, IP | Human IgG |
| TAB-332CT-F(E) | Anti-Human RON Recombinant Antibody Fab Fragment (TAB-332CT-F(E)) | WB, ELISA, FC | Human antibody |
| TAB-333CT-F(E) | Human Anti-MST1R Recombinant Antibody; Fab Fragment (TAB-333CT-F(E)) | WB, ELISA, FC, IP | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-331CT | Anti-Human RON Recombinant Antibody (TAB-331CT) | WB, ELISA, FC | |
| TAB-334CT | Mouse Anti-MST1R Recombinant Antibody (TAB-334CT) | WB, ELISA, FC, IP | Mouse IgG2a, κ |
| TAB-335CT | Mouse Anti-MST1R Recombinant Antibody (TAB-335CT) | WB, ELISA, FC, IP | Mouse IgG2a, κ |
| TAB-331CT-F(E) | Anti-Human RON Recombinant Antibody Fab Fragment (TAB-331CT-F(E)) | WB, ELISA, FC | |
| TAB-334CT-F(E) | Mouse Anti-MST1R Recombinant Antibody; Fab Fragment (TAB-334CT-F(E)) | WB, ELISA, FC, IP | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1279MZ | Recombinant Mouse Anti-Human MST1R Antibody (clone 2C6B0) | ELISA, WB | Mouse antibody |
| HPAB-0135-FY | Human Anti-MST1R Recombinant Antibody (clone sh29B06-78) | WB, ELISA | Humanized IgG1, κ |
| HPAB-0823-CN | Human Anti-MST1R Recombinant Antibody (clone MOR07919) | WB, ELISA, FC | Human IgG1, κ |
| HPAB-0265CQ | Human Anti-MST1R Recombinant Antibody (clone IMC-41A2) | ELISA, WB, FC, IP | Human IgG1, κ |
| HPAB-0266CQ | Human Anti-MST1R Recombinant Antibody (clone IMC-41A10) | ELISA, WB, FC, IP, Block | Human IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1756CQ | Recombinant Mouse Anti-MST1R Antibody (CBL312) | BL | IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1757CQ | Recombinant Mouse Anti-MST1R Antibody (MM0478-10F24) | Neut | IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2309 | Hi-Affi™ Recombinant Rabbit Anti-MST1R Monoclonal Antibody (DS2309AB) | FC, ICC, IF, IHC-P, IP, WB | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0062-CN-S(P) | Human Anti-MST1R Recombinant Antibody (clone MOR07923); scFv Fragment | IP, ELISA, FC | Human scFv |
| HPAB-0063-CN-S(P) | Human Anti-MST1R Recombinant Antibody (clone MOR07924); scFv Fragment | IP, ELISA, FC | Human scFv |
| HPAB-0064-CN-S(P) | Human Anti-MST1R Recombinant Antibody (clone MOR07925); scFv Fragment | IP, ELISA, FC | Human scFv |
| HPAB-J0189-YC-S(P) | Mouse Anti-MST1R Recombinant Antibody (clone 17F06); scFv Fragment | ELISA, Neut, FuncS | Mouse scFv |
| HPAB-J0190-YC-S(P) | Human Anti-MST1R Recombinant Antibody (clone Ch07F01 C102S); scFv Fragment | ELISA, Neut, FuncS | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0821-CN-F(E) | Human Anti-MST1R Recombinant Antibody (clone MOR07692); Fab Fragment | WB, ELISA, FC | Human Fab |
| HPAB-0823-CN-F(E) | Human Anti-MST1R Recombinant Antibody (clone MOR07919); Fab Fragment | WB, ELISA, FC | Human Fab |
| HPAB-687-FY-F(E) | Mouse Anti-MST1R Recombinant Antibody (clone 07F01); Fab Fragment | Inhib, ELISA, FC | Mouse Fab |
| HPAB-688-FY-F(E) | Mouse Anti-MST1R Recombinant Antibody (clone 29B06); Fab Fragment | Inhib, ELISA, FC | Mouse Fab |
| HPAB-689-FY-F(E) | Mouse Anti-MST1R Recombinant Antibody (clone 18H09); Fab Fragment | Inhib, ELISA, FC | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-184 | Afuco™ Anti-MST1R ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-184) | FuncS, IF, Neut, ELISA, FC, IP | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY190 | AbPlus™ Anti-MST1R Magnetic Beads (MOR07923) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY152 | Human Anti-MST1R (clone M93-D02) scFv-Fc Chimera | WB, ELISA, FC, IP | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC486 | Recombinant Anti-MST1R Vesicular Antibody, EV Displayed (VS-0425-YC486) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY4549 | Anti-MST1R Immunohistochemistry Kit | IHC |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: WB, FC, IP, ELISA, Neut, FuncS, IF
Application: ELISA, IP, FC, FuncS, Neut, IF, ICC
Application: Neut, ELISA, IF, IP, FuncS, FC, IHC
Application: FC, IP, ELISA, Neut, FuncS, IF, WB
Application: ELISA, Neut, FuncS
Application: ELISA, SPR, Inhib, FuncS
Application: ELISA
Application: SPR, Inhib, FuncS
Application: Neut, ELISA, FuncS
Application: FC
Application: ELISA, FuncS, RIA, IP, IF, IHC, IA, Block
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
