Anti-NaPi2b-vc-MMAE ADC (CAT#: ADC-054LZY)

This ADC product is composed of an anti-NaPi2b antibody conjugated via vc linker to MMAE (anti-NaPi2b-vc-MMAE). It is in Phase II clinical trials and has demonstrated a response in Ovarian cancer treatment by a MOA (Mechanism of Action) of microtubules depolymerizing.


Specific Inquiry
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Normal Tissue
RNA Expression

Specifications

  • Antibody Overview
  • Humanized Anti-NaPi2b IgG1
  • Antibody Isotype
  • IgG1
  • Antibody Conjugation
  • Coupling reaction: Cys +maleimide
  • Linker
  • VC (valine-citrulline)
  • Linker Class/Description
  • Class: peptide linker
    Description: peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.
  • Drug
  • MMAE (monomethyl auristatin E)
  • Drug Class/Description
  • Class: Auristatin
    Description: Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

Target

  • Introduction
  • The protein encoded by this gene is a pH-sensitive sodium-dependent phosphate transporter. Phosphate uptake is increased at lower pH. Defects in this gene are a cause of pulmonary alveolar microlithiasis. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, May 2010]
  • Alternative Names
  • SLC34A2; solute carrier family 34 (type II sodium/phosphate cotransporter), member 2; NPTIIb; NAPI-3B; NAPI-IIb; sodium-dependent phosphate transport protein 2B; sodium/phosphate cotransporter 2B; type II sodium-dependent phosphate transporter 3b; solute carrier family 34 (sodium phosphate), member 2;

Downloads

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Human Antibody

CAT Product Name Application Type
TAB-H45 Human Anti-SLC34A2 Recombinant Antibody (clone Lifastuzumab) ELISA, FC, IP, FuncS, IF, Neut, ICC Human IgG1, κ

Humanized Antibody

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-H45 Afuco™ Anti-SLC34A2 ADCC Recombinant Antibody (Lifastuzumab), ADCC Enhanced ELISA, FC, IP, FuncS, IF, Neut ADCC enhanced antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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