Afuco™ Anti-SLC34A2 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H45)
CAT#: AFC-TAB-H45
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant human antibody to Human SLC34A2.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line RPTEC TERT1
Immunofluorescent staining of human cell line RPTEC TERT1 shows localization to nucleoplasm, plasma membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/37989/1788_A4_7_cr5971b651a2dbe_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line RPTEC TERT1
Immunofluorescent staining of human cell line RPTEC TERT1 shows localization to plasma membrane & vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/66474/1788_E8_17_cr5971fcb00a73f_selected.jpg
Normal Tissue
Figure 3 High expression in lung
Alveolar cells type Alveolar cells type I I Staining: High Intensity: Strong Quantity:>75%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/37989/141847_A_2_4.jpg
RNA Expression
Figure 4 RNA cell line category: Group enriched (BEWO, EFO-21, RPTEC TERT1)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000157765-SLC34A2
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Specifications
- Host Species
- Human
- Derivation
- human
- Type
- ADCC enhanced antibody
- Specificity
- SLC34A2 (solute carrier family 34 sodium phosphate member 2, sodium/phosphate cotransporter 2B, NaPi2b, NaPi3b, NAPI-3B) [Homo sapiens]
- Species Reactivity
- Human
- Applications
- ELISA, FC, IP, FuncS, IF, Neut
- Conjugate
- Unconjugated
- Generic Name
- Lifastuzumab
- Related Disease
- Ovarian cancers
Product Property
- Purity
- >95% by SDS-PAGE
- Storage
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
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A Catalytic Tool for Oncological Research
As a catalytic tool in oncological research, this antibody facilitates a deeper understanding of phosphate transporter roles in cancer progression, making it invaluable for our ongoing studies in metabolic disorder analysis.
Promising for Targeted Cancer Therapy
Its specificity to SLC34A2 has been instrumental in highlighting promising approaches in targeted cancer therapies. By exploring its use in enhanced ADCC, we're opening pathways to more selective and effective treatments.
Perfect for Longitudinal Studies
Perfect for longitudinal studies, the antibody's high repeatability ensures consistency across numerous experiments, supporting extended research needs and facilitating comprehensive cancer studies.
Q&As
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What is the primary use of the Afuco™ Anti-SLC34A2 ADCC Recombinant Antibody
A: This recombinant antibody is used primarily in oncology research to target the SLC34A2 protein, which is implicated in ovarian cancers. Its applications in ELISA, Flow Cytometry (FC), Immunoprecipitation (IP), Functional Studies (FuncS), Immunofluorescence (IF), and neutralization assays make it a key tool in understanding tumor biology and developing targeted therapies.
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How does this antibody enhance ADCC in cancer research?
A: The antibody has been engineered for enhanced antibody-dependent cellular cytotoxicity (ADCC), increasing its ability to recruit immune cells to kill cancer cells expressing SLC34A2. This improvement makes it valuable in studying therapeutic pathways and developing antibody-mediated treatments that harness the body's immune system.
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How does this antibody facilitate the study of sodium/phosphate cotransporters?
A: Targeting SLC34A2, a key sodium/phosphate cotransporter, this antibody helps elucidate its role in metabolic pathways and cancer. It supports research aiming to understand how disrupting transporter activity could be leveraged for therapeutic ends.
View the frequently asked questions answered by Creative Biolabs Support.
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Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
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|---|---|---|---|
| MOB-1661z-F(E) | Recombinant Anti-Human SLC34A2 Antibody Fab Fragment | IF, FC, FuncS | Fab |
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| HPAB-M0659-YC-F(E) | Human Anti-SLC34A2 Recombinant Antibody; Fab Fragment (HPAB-M0659-YC-F(E)) | FC, IHC, FuncS | Humanized Fab |
| HPAB-M0281-YC-F(E) | Human Anti-SLC34A2 Recombinant Antibody; Fab Fragment (HPAB-M0281-YC-F(E)) | FuncS | Human Fab |
| HPAB-M0282-YC-F(E) | Human Anti-SLC34A2 Recombinant Antibody; Fab Fragment (HPAB-M0282-YC-F(E)) | FC, FuncS | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1661z-S(P) | Recombinant Anti-Human SLC34A2 Antibody scFv Fragment | FC, IP, FuncS | scFv |
| HPAB-0341LY-S(P) | Human Anti-SLC34A2 Recombinant Antibody; scFv Fragment (HPAB-0341LY-S(P)) | ELISA, Block | Humanized scfv |
| HPAB-M0659-YC-S(P) | Human Anti-SLC34A2 Recombinant Antibody; scFv Fragment (HPAB-M0659-YC-S(P)) | FC, IHC, FuncS | Humanized scFv |
| HPAB-M0281-YC-S(P) | Human Anti-SLC34A2 Recombinant Antibody; scFv Fragment (HPAB-M0281-YC-S(P)) | FuncS | Human scFv |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-H45 | Human Anti-SLC34A2 Recombinant Antibody (TAB-H45) | ELISA, FC, IP, FuncS, IF, Neut, ICC | Human IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-467MZ | Mouse Anti-SLC34A2 Recombinant Antibody (TAB-467MZ) | FC, Inhib | Mouse IgG1 |
| TAB-467MZ-S(P) | Mouse Anti-SLC34A2 Recombinant Antibody; scFv Fragment (TAB-467MZ-S(P)) | SDS-PAGE, IHC, WB | Mouse scFv |
| TAB-467MZ-F(E) | Mouse Anti-SLC34A2 Recombinant Antibody; Fab Fragment (TAB-467MZ-F(E)) | SDS-PAGE, IHC, WB | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-468MZ | Human Anti-SLC34A2 Recombinant Antibody (TAB-468MZ) | FC, Inhib | Humanized antibody |
| TAB-468MZ-S(P) | Human Anti-SLC34A2 Recombinant Antibody; scFv Fragment (TAB-468MZ-S(P)) | SDS-PAGE, IHC, WB | Humanized scFv |
| TAB-468MZ-F(E) | Human Anti-SLC34A2 Recombinant Antibody; Fab Fragment (TAB-468MZ-F(E)) | SDS-PAGE, IHC, WB | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0341LY | Human Anti-SLC34A2 Recombinant Antibody (HPAB-0341LY) | ELISA, Block | Humanized IgG1 |
| HPAB-M0659-YC | Human Anti-SLC34A2 Recombinant Antibody (HPAB-M0659-YC) | FC, IHC, FuncS | Humanized IgG |
| HPAB-M0281-YC | Human Anti-SLC34A2 Recombinant Antibody (HPAB-M0281-YC) | FuncS | Human IgG1 |
| HPAB-M0282-YC | Human Anti-SLC34A2 Recombinant Antibody (HPAB-M0282-YC) | FC, FuncS | Human IgG1 |
| HPAB-N0246-YC | Human Anti-SLC34A2 Recombinant Antibody (HPAB-N0246-YC) | FuncS | Humanized IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY167 | Human Anti-SLC34A2 scFv-Fc Chimera (VS-0425-FY167) | IHC | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC70 | Recombinant Anti-SLC34A2 Vesicular Antibody, EV Displayed (VS-0425-YC70) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
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| VS-0525-XY6677 | Anti-SLC34A2 Immunohistochemistry Kit | IHC |
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