Anti-PRLR-SMCC-DM1 ADC
CAT#: ADC-074CL
This ADC product is composed of an anti-prolactin receptor (PRLR) antibody conjugated via SMCC linker to DM1(anti-PRLR-SMCC-DM1). It has demonstrated a response in various cancers as well as other PRLR-related disorders treatment.
Gene Expression
RNA Expression
Figure 1 RNA cell line category: Cell line enriched (T-47d)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000113494-PRLR/subcellular
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Specifications
- Antibody Overview
- Anti-PRLR Antibody,
- Linker
- SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
- Linker Class/Description
- Class: Noncleavable linkers
Description: Noncleavable linker is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation.
- Drug
- maytansinoid DM1 (maytansinoid N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
- Drug Class/Description
- Class: Maytansinoid
Description: Maytansinoids are a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. The eponymous natural cytotoxic agent maytansine is a 19-member lactam (ansa
macrolide) structure originally isolated from the Ethiopian shrub Maytenus ovatus. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells.
Target
- Introduction
- This gene encodes a receptor for the anterior pituitary hormone, prolactin, and belongs to the type I cytokine receptor family. Prolactin-dependent signaling occurs as the result of ligand-induced dimerization of the prolactin receptor. Several alternatively spliced transcript variants encoding different membrane-bound and soluble isoforms have been described for this gene, which may function to modulate the endocrine and autocrine effects of prolactin in normal tissue and cancer. [provided by RefSeq, Feb 2011]
- Alternative Names
- PRLR; prolactin receptor; HPRL; MFAB; hPRLrI; hPRL receptor; secreted prolactin binding protein;
- Gene ID
- 5618
- UniProt ID
- P16471
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Datasheet
MSDS
COA
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See other products for "PRLR"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABZ-179 | Mouse Anti-PRLR Recombinant Antibody (clone A8) | ELISA, Neut, WB | Mouse IgG |
| PABL-682 | Mouse Anti-PRLR Recombinant Antibody (clone sAB A8) | ELISA | Mouse IgG |
| HPAB-0029-CN | Human Anti-PRLR Recombinant Antibody (HPAB-0029-CN) | WB, ELISA, IHC, FC | Human IgG |
| HPAB-0030-CN | Human Anti-PRLR Recombinant Antibody (HPAB-0030-CN) | WB, ELISA, IHC, FC | Human IgG |
| VS-0723-WK112 | Human Anti-PRLR Recombinant Antibody (VS-0723-WK112) | FC | Chimeric (rabbit/human) IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBZ-179 | Mouse Anti-PRLR Recombinant Antibody (clone A8); Fab Fragment | ELISA, Neut, WB | Mouse Fab |
| PSBL-676 | Mouse Anti-PRLR Recombinant Antibody (clone sAB A8); scFv Fragment | ELISA | Mouse scFv |
| HPAB-0029-CN-S(P) | Human Anti-PRLR Recombinant Antibody; scFv Fragment (HPAB-0029-CN-S(P)) | WB, ELISA, IHC, FC | Human scFv |
| HPAB-0030-CN-S(P) | Human Anti-PRLR Recombinant Antibody; scFv Fragment (HPAB-0030-CN-S(P)) | WB, ELISA, IHC, FC | Human scFv |
| MOB-219YJL-S(P) | Human Anti-PRLR Recombinant Antibody; scFv Fragment (MOB-219YJL-S(P)) | ELISA, FC, Inhib | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBZ-179 | Mouse Anti-PRLR Recombinant Antibody (clone A8); scFv Fragment | ELISA, Neut, WB | Mouse scFv |
| HPAB-0029-CN-F(E) | Human Anti-PRLR Recombinant Antibody; Fab Fragment (HPAB-0029-CN-F(E)) | WB, ELISA, IHC, FC | Human Fab |
| HPAB-1600-FY-S(P) | Human Anti-PRLR Recombinant Antibody; scFv Fragment (HPAB-1600-FY-S(P)) | FC, WB, ELISA | Human scFv |
| HPAB-1601-FY-S(P) | Human Anti-PRLR Recombinant Antibody; scFv Fragment (HPAB-1601-FY-S(P)) | FC, WB, ELISA | Human scFv |
| HPAB-1602-FY-S(P) | Human Anti-PRLR Recombinant Antibody; scFv Fragment (HPAB-1602-FY-S(P)) | FC, WB, ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1064CL | Human Anti-PRLR Recombinant Antibody (TAB-1064CL) | FC | Human IgG |
| TAB-1067CL | Human Anti-PRLR Recombinant Antibody (TAB-1067CL) | ELISA | Human IgG2 |
| TAB-1064CL-S(P) | Human Anti-PRLR Recombinant Antibody (TAB-1064CL-S(P)); scFv Fragment | FC | Human scFv |
| TAB-1064CL-F(E) | Human Anti-PRLR Recombinant Antibody (TAB-1064CL-F(E)); Fab Fragment | FC | Human Fab |
| TAB-1067CL-F(E) | Human Anti-PRLR Recombinant Antibody; Fab Fragment (TAB-1067CL-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1065CL | Mouse Anti-PRLR Recombinant Antibody (TAB-1065CL) | ELISA, FuncS | Mouse IgG |
| TAB-1065CL-S(P) | Mouse Anti-PRLR Recombinant Antibody; scFv Fragment (TAB-1065CL-S(P)) | ELISA | Mouse scFv |
| TAB-1065CL-F(E) | Mouse Anti-PRLR Recombinant Antibody; Fab Fragment (TAB-1065CL-F(E)) | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1066CL | Human Anti-PRLR Recombinant Antibody (TAB-1066CL) | ELISA | Humanized IgG |
| TAB-1066CL-S(P) | Human Anti-PRLR Recombinant Antibody; scFv Fragment (TAB-1066CL-S(P)) | ELISA | Humanized scFv |
| TAB-1066CL-F(E) | Human Anti-PRLR Recombinant Antibody; Fab Fragment (TAB-1066CL-F(E)) | ELISA | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1881CQ | Recombinant Mouse Anti-PRLR Antibody (CBL154) | Neut, WB | IgG1 |
| NEUT-1882CQ | Recombinant Mouse Anti-PRLR Antibody (CBL359) | Neut, WB | IgG1 |
| NEUT-1883CQ | Recombinant Mouse Anti-PRLR Antibody (6G8) | Neut, WB | IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1884CQ | Recombinant Mouse Anti-PRLR Antibody (T6) | BL, FC, ICC, IF, IHC, IP, WB | IgG2a |
| NEUT-1885CQ | Recombinant Mouse Anti-PRLR Antibody (U5) | BL, FC, ICC, IF, IHC, IHC-Fr, IHC-P, IP, WB | IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2867 | Hi-Affi™ Recombinant Rabbit Anti-PRLR Monoclonal Antibody (DS2867AB) | WB, IHC-P, ICC, IF | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-XY40 | Mouse Anti-Prlr Agonistic Antibody (VS-0724-XY40) | Agonistic assays | Mouse IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC375 | Recombinant Anti-PRLR Vesicular Antibody, EV Displayed (VS-0425-YC375) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY5714 | Anti-PRLR Immunohistochemistry Kit | IHC | |
| VS-0525-XY5715 | Anti-Mouse PRLR Immunohistochemistry Kit | IHC | |
| VS-0525-XY5716 | Anti-Rat PRLR Immunohistochemistry Kit | IHC | |
| VS-0525-XY5717 | Anti-Rabbit PRLR Immunohistochemistry Kit | IHC |
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