Mouse Anti-PRLR Recombinant Antibody (clone sAB A8) (CAT#: PABL-682)
Recombinant Mouse Antibody (sAB A8) is capable of binding to PRLR.
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Figure 1 sAB inhibition of hPRL-R in T47D breast cancer cells.
Fluorescence microscopy images of cells treated with 100 nM cy5-hPRL (a) or cy5-hGH (b) in the presence of each sAB.
Rizk, S. S., Kouadio, J. L. K., Szymborska, A., Duguid, E. M., Mukherjee, S., Zheng, J., ... & Kossiakoff, A. A. (2015). Engineering synthetic antibody binders for allosteric inhibition of prolactin receptor signaling. Cell Communication and Signaling, 13(1), 1.
Figure 2 sAB inhibition of hPRL-R in T47D breast cancer cells.
Western blot detection of the time-dependent inhibition of hPRL-R signaling by hPRL-R sABs.
Rizk, S. S., Kouadio, J. L. K., Szymborska, A., Duguid, E. M., Mukherjee, S., Zheng, J., ... & Kossiakoff, A. A. (2015). Engineering synthetic antibody binders for allosteric inhibition of prolactin receptor signaling. Cell Communication and Signaling, 13(1), 1.
Figure 3 Crystal structure of the hPRL-R in complex with sAB A8.
Inhibition of sAB binding by hGH or PRL using phage ELISA. Both hGH (left panel) and PRL (right panel) inhibit the interaction between phage-displayed sABs and hPRL-R in a concentration dependent manner.
Rizk, S. S., Kouadio, J. L. K., Szymborska, A., Duguid, E. M., Mukherjee, S., Zheng, J., ... & Kossiakoff, A. A. (2015). Engineering synthetic antibody binders for allosteric inhibition of prolactin receptor signaling. Cell Communication and Signaling, 13(1), 1.
Figure 4 sAB inhibition of hPRL-R in T47D breast cancer cells.
A Stat5 phospholyration luciferase reporter assay of T47D cells in the presence or absence of hPRL and hPRL-R sABs. A sAB against bacterial maltose binding protein (MBP) was used as a negative control.
Rizk, S. S., Kouadio, J. L. K., Szymborska, A., Duguid, E. M., Mukherjee, S., Zheng, J., ... & Kossiakoff, A. A. (2015). Engineering synthetic antibody binders for allosteric inhibition of prolactin receptor signaling. Cell Communication and Signaling, 13(1), 1.
Specifications
- Immunogen
- Human prolactin receptor
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Human PRLR
- Species Reactivity
- Human
- Clone
- sAB A8
- Applications
- ELISA
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- PRLR; prolactin receptor; HPRL; MFAB; hPRLrI; hPRL receptor; secreted prolactin binding protein
- Gene ID
- 5618
- UniProt ID
- P16471
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-198 | Mouse Anti-PRLR Recombinant Antibody (clone CBL11Q) | WB, ELISA, FuncS | Mouse IgG |
| HPAB-0036-CN | Human Anti-PRLR Recombinant Antibody (HPAB-0036-CN) | WB, ELISA, IHC, FC | Chimeric (mouse/human) IgG |
| HPAB-0037-CN | Human Anti-PRLR Recombinant Antibody (HPAB-0037-CN) | WB, ELISA, IHC, FC | Chimeric (mouse/human) IgG |
| MOB-219YJL | Human Anti-PRLR Recombinant Antibody (MOB-219YJL) | ELISA, FC, Inhib | Human IgG1 |
| VS4-CJ91 | Recombinant Human Anti-PRLR Antibody (clone 1D3) | ELISA | Human IgG2 |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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