Anti-Robo4-mPEO-DM1 ADC
CAT#: ADC-268CL
This ADC product is composed of an anti-Robo4 antibody conjugated via mPEO linker to DM1(anti-Robo4-Mpeo-DM1). It has demonstrated a response in treatment by a MOA (Mechanism of Action) of microtubules depolymerizing.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line PC-3
Immunofluorescent staining of human cell line PC-3 shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/65212/1589_F7_2_selected.jpg
RNA Expression
Figure 2 RNA cell line category: Group enriched (HUVEC TERT2, TIME)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000154133-ROBO4
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Specifications
- Antibody Overview
- Anti-Robo4 Antibody,
- Linker
- Mpeo (methoxy-polyethylene oxide)
- Drug
- DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
- Drug Class/Description
- Class: Maytansinoid
Description: Maytansinoids are a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. The eponymous natural cytotoxic agent maytansine is a 19-member lactam (ansa
macrolide) structure originally isolated from the Ethiopian shrub Maytenus ovatus. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells.
Target
- Introduction
- ROBO4 (Roundabout, Axon Guidance Receptor, Homolog 4 (Drosophila)) is a Protein Coding gene. Among its related pathways are Development Slit-Robo signaling. GO annotations related to this gene include receptor activity.
- Alternative Names
- ROBO4; roundabout, axon guidance receptor, homolog 4 (Drosophila); MRB; ECSM4; roundabout homolog 4; roundabout homolog 4, magic roundabout;
- Gene ID
- 54538
- UniProt ID
- B4DYV8
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Datasheet
MSDS
COA
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See other products for "ROBO4"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-329CT | Mouse Anti-Robo4 Recombinant Antibody (TAB-329CT) | WB, ELISA, FC, IHC | Mouse IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-330CT | Anti-Human Robo4 Recombinant Antibody (YW79.11) | WB, ELISA, FC | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-329CT-S(P) | Mouse Anti-Robo4 Recombinant Antibody; scFv Fragment (TAB-329CT-S(P)) | WB, ELISA, FC, IHC | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-330CT-S(P) | Anti-Human Robo4 Recombinant Antibody scFv Fragment (YW79.11) | WB, ELISA, FC | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-329CT-F(E) | Mouse Anti-Robo4 Recombinant Antibody; Fab Fragment (TAB-329CT-F(E)) | WB, ELISA, FC, IHC | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-330CT-F(E) | Anti-Human Robo4 Recombinant Antibody Fab Fragment (YW79.11) | WB, ELISA, FC | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4396 | Hi-Affi™ Recombinant Rabbit Anti-ROBO4 Monoclonal Antibody (SI487DS) | ELISA | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-076CN | Human Anti-ROBO4 Recombinant Antibody (clone YW71.22) | FC, ELISA, FuncS | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-076CN-F(E) | Human Anti-ROBO4 Recombinant Antibody (clone YW71.22); Fab Fragment | FC, ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-076CN-S(P) | Human Anti-ROBO4 Recombinant Antibody (clone YW71.22); scFv Fragment | FC, ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0045-WJ | Human Anti-ROBO4 Recombinant Antibody (HPAB-0045-WJ) | ELISA, RIA | Humanized IgG2, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0045-WJ-S(P) | Human Anti-ROBO4 Recombinant Antibody; scFv Fragment (HPAB-0045-WJ-S(P)) | ELISA, RIA | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0045-WJ-F(E) | Human Anti-ROBO4 Recombinant Antibody; Fab Fragment (HPAB-0045-WJ-F(E)) | ELISA, RIA | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0234-YC | Human Anti-ROBO4 Recombinant Antibody (HPAB-N0234-YC) | FC, Activ | Humanized (mouse/human) IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0234-YC-S(P) | Human Anti-ROBO4 Recombinant Antibody; scFv Fragment (HPAB-N0234-YC-S(P)) | FC, Activ | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0234-YC-F(E) | Human Anti-ROBO4 Recombinant Antibody; Fab Fragment (HPAB-N0234-YC-F(E)) | FC, Activ | Humanized (mouse/human) Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-AP412-YC | Human Anti-ROBO4 Recombinant Antibody (clone cMAb1-1) | ELISA, FC | Chimeric (mouse/human) IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-AP413-YC | Human Anti-ROBO4 Recombinant Antibody (clone cMAb1-2) | ELISA, FC | Chimeric (mouse/human) IgG2 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-AP412-YC-S(P) | Human Anti-ROBO4 Recombinant Antibody (clone cMAb1-1); scFv Fragment | ELISA, FC | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-AP413-YC-S(P) | Human Anti-ROBO4 Recombinant Antibody (clone cMAb1-2); scFv Fragment | ELISA, FC | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-AP412-YC-F(E) | Human Anti-ROBO4 Recombinant Antibody (clone cMAb1-1); Fab Fragment | ELISA, FC | Chimeric (mouse/human) Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-AP413-YC-F(E) | Human Anti-ROBO4 Recombinant Antibody (clone cMAb1-2); Fab Fragment | ELISA, FC | Chimeric (mouse/human) Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-J0217-YC | Human Anti-ROBO4 Recombinant Antibody (clone YW71.6) | ELISA | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-J0217-YC-S(P) | Human Anti-ROBO4 Recombinant Antibody (clone YW71.6); scFv Fragment | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-J0217-YC-F(E) | Human Anti-ROBO4 Recombinant Antibody (clone YW71.6); Fab Fragment | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC496 | Recombinant Anti-ROBO4 Vesicular Antibody, EV Displayed (VS-0425-YC496) | ELISA, FC, Cell-uptake |
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