Human Anti-AChR Recombinant Antibody (clone 131)
CAT#: VS-0723-CJ38
This product recognizes human AchR. IgG1-131 binds the γ-subunit of fetal AChR with high specificity and sub-nanomolar apparent affinity. Mab 131 blocked one of the two α-bungarotoxin binding sites on the fetal AChR, and partially blocked the binding of an antibody (mAb 637) to the α-subunit of the AChR. mAb 131 does not cross-react with AChRs of mouse, rat or rhesus monkey muscle and also does not bind to AChR from Torpedo electric organ which is of the gamma type (independent of development).
Specifications
- Host Species
- Human
- Type
- Human IgG1
- Specificity
- Human AchR
- Species Reactivity
- Human
- Clone
- 131
- Applications
- ELISA, WB, IF, Inhib, DB
- Conjugate
- Unconjugated
- Related Disease
- Myasthenia gravis; Rhabdomyosarcoma; Arthrogryposis multiplex congenita
Product Property
- Purification
- Protein A purified
- Purity
- >95%
- Buffer
- PBS
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- mAb 131 did not reduce fetal AChR ion channel currents in electrophysiological experiments. mAb 131 did not the adult type AChR and the gamma type AChR (independent of development).
Target
- Alternative Names
- Alpha subunit of the acetylcholine receptor
REVIEWS AND Q&AS
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Superior blocking optimization
With proper blocking steps, the antibody provided clean results. Effective against background issues in various experimental setups.
Robust and reliable
The robustness of this antibody has made it a reliable tool across multiple projects. It's consistently dependable.
Multi-species reactivity
Validated this antibody in different cell lines, and it maintained high reactivity and specificity. Truly versatile.
Q&As
-
What are the consequences of freeze-thaw cycles for this antibody?
A: Repeated freeze-thaw cycles can cause antibody denaturation and decrease its binding efficiency. Aliquoting is recommended to maintain long-term stability.
-
What factors can influence the performance of this antibody in assays?
A: Factors such as buffer composition, antibody concentration, incubation times, and blocking conditions can influence the antibody's performance. Optimization may be required.
-
How can I reduce non-specific binding in my assay?
A: Use appropriate blocking agents like BSA or non-fat milk, optimize antibody dilution, and include thorough washing steps to reduce non-specific binding.
View the frequently asked questions answered by Creative Biolabs Support.
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Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
Recommended Dilution Buffer
- CAT
- Product Name
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| FAMAB-0029WJ-S(P) | Human Anti-AChR Recombinant Antibody (clone MH6); scFv Fragment | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABC-007 | Rat Anti-AChR Recombinant Antibody (clone mAb192) | WB, FuncS | Rat IgG2b, κ |
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| FAMAB-0224YC | Rat Anti-AChR Recombinant Antibody (clone mAb 195) | FuncS | Rat IgG1 |
| FAMAB-0002WJ | Human Anti-AChR Recombinant Antibody (clone 637) | RIA, IF | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0636CLV | Anti-Human AChR Recombinant Antibody (P90-131) | WB | Fully Human antibody |
| TAB-0637CLV | Anti-Human AChR Recombinant Antibody (P90-65) | RIA, IF | Fully Human antibody |
| TAB-0638CLV | Human Anti-AChR Recombinant Antibody (TAB-0638CLV) | Dot, FuncS, IF | Human IgG1 |
| TAB-0639CLV | Human Anti-AChR Recombinant Antibody (TAB-0639CLV) | RIA, IF | Human IgG |
| TAB-0638CLV-S(P) | Human Anti-AChR Recombinant Antibody; scFv Fragment (TAB-0638CLV-S(P)) | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0223-YC-F(E) | Rat Anti-AChR Recombinant Antibody (clone mAb 192); Fab Fragment | FuncS | Rat Fab |
| FAMAB-0224-YC-F(E) | Rat Anti-AChR Recombinant Antibody (clone mAb 195); Fab Fragment | FuncS | Rat Fab |
| FAMAB-0001WJ-F(E) | Human Anti-AChR Recombinant Antibody (clone 587); Fab Fragment | RIA, IP, IF | Human Fab |
| FAMAB-0002WJ-F(E) | Human Anti-AChR Recombinant Antibody (clone 637); Fab Fragment | RIA, IP, IF | Human Fab |
| FAMAB-0029WJ-F(E) | Human Anti-AChR Recombinant Antibody (clone MH6); Fab Fragment | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY203 | Human Anti-AChR scFv-Fc Chimera (VS-0325-FY203) | IF | Human IgG1, scFv-Fc |
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