Mouse Anti-ACP3 Recombinant Antibody (clone ABT-PSAP)
CAT#: VS3-CJ668
This product is a mouse antibody that recognizes human ACP3.
Gene Expression
Normal Tissue
Figure 1 Prostate
Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/63916/145610_A_2_5.jpg
RNA Expression
Figure 2 RNA cell line category: Cell line enhanced (BJ hTERT+, OE19, RPMI-8226, U-698, U-87 MG)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000014257-ACP3
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Specifications
- Immunogen
- Synthesized peptide derived from human Prostatic Acid Phosphatase (PSAP)
- Host Species
- Mouse
- Type
- Mouse IgG1, κ
- Specificity
- Human ACP3
- Species Reactivity
- Human
- Clone
- ABT-PSAP
- Applications
- IHC-P
- Conjugate
- Unconjugated
Product Property
- Purification
- Affinity Chromatography
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Buffer
- 50% Glycerol, 0.5% BSA, PBS.
- Preservative
- 0.02% Sodium Azide
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been tested for use in Immunohistochemistry-Parraffin (1:100-1:500).
Target
- Alternative Names
- ACPP; 5'-NT; ACP-3; TM-PAP
- Gene ID
- 55
- UniProt ID
- P15309
- Sequence Similarities
- Belongs to the histidine acid phosphatase family.
- Cellular Localization
- Amyloid, Cell membrane, Cytoplasm, Lysosome, Membrane, Nucleus, Secreted
- Post Translation Modifications
- N-glycosylated. High mannose content, partially sialylated and fucosylated biantennary complex. Also fucosylated with partially sialylated triantennary complex oligosaccharides.
Proteolytically cleaved in seminal fluid to produce several peptides. Peptide PAPf39, the most prominent, forms amyloid beta-sheet fibrils, SEVI (semen-derived enhancer of viral infection).
- Protein Refseq
- NP_001090.2; NP_001127666.1; NP_001278966.1
- Function
- A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins (PubMed:10506173, PubMed:15280042, PubMed:20498373, PubMed:9584846).
Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma (PubMed:10506173, PubMed:15280042).
Isoform 2:
Tyrosine phosphatase that acts as a tumor suppressor of prostate cancer through dephosphorylation of ERBB2 and deactivation of MAPK-mediated signaling (PubMed:20498373).
In addition to its tyrosine phosphatase activity has ecto-5'-nucleotidase activity in dorsal root ganglion (DRG) neurons. Generates adenosine from AMP which acts as a pain suppressor (By similarity).
PAPf39:
(Microbial infection) Forms amyloid beta-sheet fibrils in semen. These fibrils, termed SEVI (semen-derived enhancer of viral infection) capture HIV virions, attach them to target cells and enhance infection (PubMed:18083097, PubMed:19451623, PubMed:19897482).
SEVI amyloid fibrils are degraded by polyphenol epigallocatechin-3-gallate (EGCG), a constituent of green tea (PubMed:19451623).
Target cell attachment and enhancement of HIV infection is inhibited by surfen (PubMed:19897482).
Also similarly boosts XMRV (xenotropic murine leukemia virus-related virus) infection (PubMed:19403677).
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
Recommended Dilution Buffer
- CAT
- Product Name
See other products for "ACP3"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0226F | Mouse Anti-ACP3 Recombinant Antibody (MOB-0226F) | IHC-P, IF | Mouse IgG |
| MOB-0227F | Mouse Anti-ACP3 Recombinant Antibody (MOB-0227F) | IHC-P, IF | Mouse IgG |
| VS3-CJ669 | Mouse Anti-ACP3 Recombinant Antibody (clone PT1651) | IHC-P | Mouse IgG |
| VS3-CJ670 | Mouse Anti-ACP3 Recombinant Antibody (clone PT2122) | IHC-P | Mouse IgG1, κ |
| VS-0224-XY147 | Rabbit Anti-ACP3 Recombinant Antibody (clone R07-4X9) | WB, IHC-P, ICC, IF, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC47 | Recombinant Anti-ACP3 Vesicular Antibody, EV Displayed (VS-0425-YC47) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY88 | Anti-ACP3 Immunohistochemistry Kit | IHC |
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