Anti-ACVR2A Antibody Prodrug, Protease Activated (VS-1025-YC115)

Name: Anti-ACVR2A Antibody Prodrug, Protease Activated (VS-1025-YC115)
SKU: VS-1025-YC115
Rating: 5 (1 reviews)

CAT#: VS-1025-YC115

The Anti-ACVR2A Antibody Prodrug, Protease Activated (VS-1025-YC115) is an antibody prodrug comprised of a recombinant mouse antibody targeting human ACVR2A, linked to a masking peptide that conceals the active antigen-binding site via a protease-cleavable linker. The mask peptide is recombinantly attached to the amino terminus of either the light or heavy chain of the antibody, designed to block access to the antigen-binding site and physically prevent the antibody from binding to ACVR2A protein. Once the masking peptide is cleaved by matrix metalloproteinases (MMPs), the prodrug is activated, allowing the unmasked monoclonal antibody component to bind to ACVR2A effectively. ACVR2A (Activin A Receptor Type 2A) is a component of the TGF-beta receptor complex and acts as a tumor suppressor. Like TGFBR2, inactivating mutations in ACVR2A are highly characteristic of cancers with microsatellite instability (MSI), such as colorectal and endometrial cancer, preventing the tumor from responding to growth-inhibitory signals.

Gene Expression

Subcellular Location and Protein Expression Figure 1 IF staining of cell line RH-30

Immunofluorescent staining of cell line RH-30 shows localization to cytosol.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46997/1150_C7_5_blue_red_green.jpg

Subcellular Location and Protein Expression Figure 2 IF staining of cell line RT4

Immunofluorescent staining of cell line RT4 shows localization to cytosol.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46997/1421_G1_4_blue_red_green.jpg

Subcellular Location and Protein Expression Figure 3 IHC staining of human rectum

Immunohistochemical staining of human rectum shows strong cytoplasmic and membranous positivity in glandular cells.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46997/ihc_selected.jpg

Normal Tissue Figure 4 Cerebral cortex

Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous Neuronal cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
Neuropil
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46997/106208_B_7_5.jpg

Normal Tissue Figure 5 Colon

Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous
Glandular cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Peripheral nerve/ganglion
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46997/106208_A_9_3.jpg

Normal Tissue Figure 6 Liver

Hepatocytes
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46997/106208_A_7_4.jpg

Normal Tissue Figure 7 Kidney

Cells in glomeruli
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Cells in tubules
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46997/106208_A_8_5.jpg

Normal Tissue Figure 8 Testis

Cells in seminiferous ducts
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Leydig cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46997/106208_A_4_6.jpg

Normal Tissue Figure 9 Lymph node

Germinal center cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46997/106208_A_9_8.jpg

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Specifications

Host Animal
Mouse

Applications
In situ zymography (ISZ), Cytotoxicity assay (Cyt), Functional assay

Specificity
Human ACVR2A

Target
ACVR2A

Species Reactivity
Human

Isotype
IgG

Masking Approach
Affinity mask

Mask
A synthetic peptide

Protease Cleavable Linker
MMP-cleavable linker

Protease Substrate
MMPs

Purification
Protein A purified

Buffer
PBS, pH 7.4

Preservative
No preservatives

Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Target

Introduction
This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes.

Alternative Names
Activin A Receptor Type 2A; EC 2.7.11.30; ACVR2

Gene ID
92

UniProt ID
P27037

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Datasheet

Datasheet - VS-1025-YC115.pdf

MSDS

MSDS - VS-1025-YC115.pdf

COA

Certificate of Analysis Lookup

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CAT	Product Name	Application
TAB-0361CL	Anti-Human ACVR2A Recombinant Antibody (APE2990)	ELISA, FuncS, Inhib
TAB-0362CL	Anti-Human ACVR2A Recombinant Antibody (APE2991)	ELISA, FuncS, Inhib
TAB-0363CL	Anti-Human ACVR2A Recombinant Antibody (APE2665)	ELISA, FuncS, Inhib
TAB-0364CL	Anti-Human ACVR2A Recombinant Antibody (APE2666)	ELISA, FuncS, Inhib
TAB-0361CL-S(P)	Anti-Human ACVR2A Recombinant Antibody scFv Fragment (APE2990)	ELISA, FuncS, Inhib

CAT	Product Name	Application	Type
TAB-0653CLV	Mouse Anti-ACVR2A Recombinant Antibody (TAB-0653CLV)	ELISA	Mouse IgG
TAB-0653CLV-F(E)	Mouse Anti-ACVR2A Recombinant Antibody; Fab Fragment (TAB-0653CLV-F(E))	ELISA	Mouse Fab
TAB-0653CLV-S(P)	Mouse Anti-ACVR2A Recombinant Antibody; scFv Fragment (TAB-0653CLV-S(P))	ELISA	Mouse scFv

CAT	Product Name	Application	Type
MOB-0427MZ	Mouse Anti-ACVR2A Recombinant Antibody (clone 250/2)	IP, WB	Mouse IgG1
HPAB-0134-FY	Mouse Anti-ACVR2A Recombinant Antibody (HPAB-0134-FY)	ELISA, Neut	Mouse IgG
VS13-YC21	Rabbit Anti-ACVR2A Recombinant Antibody (VS13-YC21)	WB	Rabbit IgG

CAT	Product Name	Application	Type
MOR-0063	Hi-Affi™ Rabbit Anti-ACVR2A Recombinant Antibody (clone DS63AB)	WB	Rabbit IgG

CAT	Product Name	Application	Type
HPAB-0134-FY-S(P)	Mouse Anti-ACVR2A Recombinant Antibody; scFv Fragment (HPAB-0134-FY-S(P))	ELISA	Mouse scFv

CAT	Product Name	Application	Type
HPAB-0134-FY-F(E)	Mouse Anti-ACVR2A Recombinant Antibody; Fab Fragment (HPAB-0134-FY-F(E))	ELISA	Mouse Fab

CAT	Product Name	Application	Type
VS-0425-YC626	Recombinant Anti-ACVR2A Vesicular Antibody, EV Displayed (VS-0425-YC626)	ELISA, FC, Neut, Cell-uptake

CAT	Product Name	Application
VS-0525-XY137	Anti-ACVR2A Immunohistochemistry Kit	IHC
VS-0525-XY138	Anti-Human ACVR2A Immunohistochemistry Kit	IHC
VS-0525-XY139	Anti-Mouse ACVR2A Immunohistochemistry Kit	IHC

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