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ACVR2A

Anti-ACVR2A Products
- Anti-Human ACVR2A Recombinant Antibody (APE2991) (TAB-0362CL)
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- Application: ELISA, FuncS, Inhib
- Anti-Human ACVR2A Recombinant Antibody (APE2665) (TAB-0363CL)
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- Application: ELISA, FuncS, Inhib
- Anti-Human ACVR2A Recombinant Antibody (APE2666) (TAB-0364CL)
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- Application: ELISA, FuncS, Inhib
- Anti-Human ACVR2A Recombinant Antibody (TAB-011CL)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Antibody
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- Derivation: Human
- Species Reactivity: Human
- Type: ADCC enhanced antibody
- Anti-Human ACVR2A Recombinant Antibody (APE2990) (TAB-0361CL)
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- Application: ELISA, FuncS, Inhib
- Mouse Anti-ACVR2A Recombinant Antibody (HPAB-0134-FY) (HPAB-0134-FY)
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA, Neut
- Anti-Human ACVR2A Recombinant Antibody Fab Fragment (APE2665) (TAB-0363CL-F(E))
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- Application: ELISA, FuncS, Inhib
- Anti-Human ACVR2A Recombinant Antibody Fab Fragment (APE2666) (TAB-0364CL-F(E))
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- Application: ELISA, FuncS, Inhib
- Mouse Anti-ACVR2A Recombinant Antibody (clone 250/2) (MOB-0427MZ)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: IP, WB
- Anti-Human ACVR2A Recombinant Antibody scFv Fragment (APE2990) (TAB-0361CL-S(P))
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- Application: ELISA, FuncS, Inhib
- Anti-Human ACVR2A Recombinant Antibody scFv Fragment (APE2991) (TAB-0362CL-S(P))
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- Application: ELISA, FuncS, Inhib
- Anti-Human ACVR2A Recombinant Antibody scFv Fragment (APE2665) (TAB-0363CL-S(P))
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- Application: ELISA, FuncS, Inhib
- Anti-Human ACVR2A Recombinant Antibody scFv Fragment (APE2666) (TAB-0364CL-S(P))
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- Application: ELISA, FuncS, Inhib
- Anti-Human ACVR2A Recombinant Antibody Fab Fragment (APE2990) (TAB-0361CL-F(E))
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- Application: ELISA, FuncS, Inhib
- Anti-Human ACVR2A Recombinant Antibody Fab Fragment (APE2991) (TAB-0362CL-F(E))
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- Application: ELISA, FuncS, Inhib
- Mouse Anti-ACVR2A Antibody, mRNA (TAB-011CL-mRNA)
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- Species Reactivity: Human
- Mouse Anti-ACVR2A Recombinant Antibody (TAB-0653CLV) (TAB-0653CLV)
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA
- Mouse Anti-ACVR2A Recombinant Antibody; Fab Fragment (TAB-0653CLV-F(E)) (TAB-0653CLV-F(E))
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA
- Mouse Anti-ACVR2A Recombinant Antibody; scFv Fragment (TAB-0653CLV-S(P)) (TAB-0653CLV-S(P))
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA
- Mouse Anti-ACVR2A Recombinant Antibody; scFv Fragment (HPAB-0134-FY-S(P)) (HPAB-0134-FY-S(P))
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA
- Mouse Anti-ACVR2A Recombinant Antibody; Fab Fragment (HPAB-0134-FY-F(E)) (HPAB-0134-FY-F(E))
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA
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- Species Reactivity: Human
- Target: ACVR2A
- Host Animal: Mouse
- Application: ELISA, FC, Neut, Cell-uptake
- Anti-ACVR2A Immunohistochemistry Kit (VS-0525-XY137)
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- Species Reactivity: Human
- Target: ACVR2A
- Application: IHC
- Anti-Human ACVR2A Immunohistochemistry Kit (VS-0525-XY138)
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- Species Reactivity: Human, Porcine
- Target: ACVR2A
- Application: IHC
- Anti-Mouse ACVR2A Immunohistochemistry Kit (VS-0525-XY139)
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- Species Reactivity: Human, Mouse, Rat
- Target: ACVR2A
- Application: IHC
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB
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For Research Use Only. Not For Clinical Use.
Background
This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain and a cytoplasmic serine-threonine kinase domain. This gene may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jun 2013]
Protein class
Cancer-related genes, Enzymes, Metabolic proteins
Predicted location
Membrane
Single cell type specificity
Cell type enhanced (Oligodendrocyte precursor cells, Inhibitory neurons, Excitatory neurons)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (HHSteC, RH-30)
Interaction
Interacts with AIP1. Part of a complex consisting of AIP1, ACVR2A, ACVR1B and SMAD3 (By similarity). Interacts with type I receptor ACVR1 (PubMed:17911401). Interacts with BMP7 (PubMed:12667445).
Molecular function
Kinase, Receptor, Serine/threonine-protein kinase, Transferase
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