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  • Anti-Human ACVR2A Recombinant Antibody (APE2990)

Anti-Human ACVR2A Recombinant Antibody (APE2990) (CAT#: TAB-0361CL)

The anti-ActRII antibody APE2990 specifically targets an activin receptor I, which is related to the regulation of muscle growth. By effectively neutralizing the ActllR activity, APE2990 can be used in the treatment of muscle wasting and in the regulation of muscle growth.

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Subcellular Location and Protein Expression
Figure 1 IF staining of cell line RH-30
Figure 1 IF staining of cell line RH-30
(Immunofluorescent staining of cell line RH-30 shows localization to cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46997/1150_C7_5_blue_red_green.jpg
Figure 2 IF staining of cell line RT4
Figure 2 IF staining of cell line RT4
(Immunofluorescent staining of cell line RT4 shows localization to cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46997/1421_G1_4_blue_red_green.jpg
Figure 3 IHC staining of human rectum
Figure 3 IHC staining of human rectum
(Immunohistochemical staining of human rectum shows strong cytoplasmic and membranous positivity in glandular cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46997/ihc_selected.jpg
Normal Tissue
Figure 4 Cerebral cortex
Figure 4 Cerebral cortex
(Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous Neuronal cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
Neuropil
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46997/106208_B_7_5.jpg
Figure 5 Colon
Figure 5 Colon
(Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous
Glandular cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Peripheral nerve/ganglion
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46997/106208_A_9_3.jpg
Figure 6 Liver
Figure 6 Liver
(Hepatocytes
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46997/106208_A_7_4.jpg
Figure 7 Kidney
Figure 7 Kidney
(Cells in glomeruli
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Cells in tubules
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46997/106208_A_8_5.jpg
Figure 8 Testis
Figure 8 Testis
(Cells in seminiferous ducts
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Leydig cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46997/106208_A_4_6.jpg
Figure 9 Lymph node
Figure 9 Lymph node
(Germinal center cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46997/106208_A_9_8.jpg

Specifications

  • Host Species
  • Human
  • Specificity
  • Human
  • Clone
  • APE2990
  • Related Disease
  • ActRII-mediated, muscle wasting disorder

Target

  • Alternative Names
  • ACVR2A; activin A receptor, type IIA

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

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Human Antibody Products Mouse Antibody Products IgG Antibody Products Rabbit Monoclonal Antibody Products ScFv Antibody Products Fab Antibody Products
CAT Product Name Application Type
TAB-0362CL Anti-Human ACVR2A Recombinant Antibody (APE2991) ELISA, FuncS, Inhib
TAB-0361CL-F(E) Anti-Human ACVR2A Recombinant Antibody Fab Fragment (APE2990) ELISA, FuncS, Inhib
TAB-0362CL-F(E) Anti-Human ACVR2A Recombinant Antibody Fab Fragment (APE2991) ELISA, FuncS, Inhib
TAB-0363CL-F(E) Anti-Human ACVR2A Recombinant Antibody Fab Fragment (APE2665) ELISA, FuncS, Inhib
TAB-0364CL-F(E) Anti-Human ACVR2A Recombinant Antibody Fab Fragment (APE2666) ELISA, FuncS, Inhib

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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