Recombinant Anti-ACVR2A Vesicular Antibody, EV Displayed (VS-0425-YC626)
CAT#: VS-0425-YC626
The Recombinant Anti-ACVR2A Vesicular Antibody, EV Displayed (VS-0425-YC626) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to ACVR2A-expressed cells or tissues. ACVR2A mediates activin signaling, influencing processes like preeclampsia susceptibility. It functions through transmembrane serine-threonine kinase receptor complexes.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of cell line RH-30
Immunofluorescent staining of cell line RH-30 shows localization to cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46997/1150_C7_5_blue_red_green.jpg
Subcellular Location and Protein Expression
Figure 2 IF staining of cell line RT4
Immunofluorescent staining of cell line RT4 shows localization to cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46997/1421_G1_4_blue_red_green.jpg
Subcellular Location and Protein Expression
Figure 3 IHC staining of human rectum
Immunohistochemical staining of human rectum shows strong cytoplasmic and membranous positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46997/ihc_selected.jpg
Normal Tissue
Figure 4 Cerebral cortex
Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous Neuronal cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
Neuropil
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46997/106208_B_7_5.jpg
Normal Tissue
Figure 5 Colon
Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous
Glandular cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Peripheral nerve/ganglion
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46997/106208_A_9_3.jpg
Normal Tissue
Figure 6 Liver
Hepatocytes
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46997/106208_A_7_4.jpg
Normal Tissue
Figure 7 Kidney
Cells in glomeruli
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Cells in tubules
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46997/106208_A_8_5.jpg
Normal Tissue
Figure 8 Testis
Cells in seminiferous ducts
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Leydig cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46997/106208_A_4_6.jpg
Normal Tissue
Figure 9 Lymph node
Germinal center cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46997/106208_A_9_8.jpg
❮
❯
Recombinant Antibody
- Application
- ELISA, FC, Neut, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- ACVR2A
- Host Animal
- Mouse
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Activin A receptor type 2A
- Molecular Function
- Kinase, Receptor, Serine/threonine-protein kinase, Transferase
- Cellular Localization
- Cytosol
- Introduction
- This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain and a cytoplasmic serine-threonine kinase domain. This gene may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jun 2013]
- Alternative Names
- ACTRII, ACVR2
- Gene ID
- 92
- UniProt ID
- P27037
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Datasheet
MSDS
COA
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| TAB-0361CL-S(P) | Anti-Human ACVR2A Recombinant Antibody scFv Fragment (APE2990) | ELISA, FuncS, Inhib | |
| TAB-0362CL-S(P) | Anti-Human ACVR2A Recombinant Antibody scFv Fragment (APE2991) | ELISA, FuncS, Inhib | |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0653CLV | Mouse Anti-ACVR2A Recombinant Antibody (TAB-0653CLV) | ELISA | Mouse IgG |
| TAB-0653CLV-F(E) | Mouse Anti-ACVR2A Recombinant Antibody; Fab Fragment (TAB-0653CLV-F(E)) | ELISA | Mouse Fab |
| TAB-0653CLV-S(P) | Mouse Anti-ACVR2A Recombinant Antibody; scFv Fragment (TAB-0653CLV-S(P)) | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0427MZ | Mouse Anti-ACVR2A Recombinant Antibody (clone 250/2) | IP, WB | Mouse IgG1 |
| HPAB-0134-FY | Mouse Anti-ACVR2A Recombinant Antibody (HPAB-0134-FY) | ELISA, Neut | Mouse IgG |
| VS13-YC21 | Rabbit Anti-ACVR2A Recombinant Antibody (VS13-YC21) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0063 | Hi-Affi™ Rabbit Anti-ACVR2A Recombinant Antibody (clone DS63AB) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0134-FY-S(P) | Mouse Anti-ACVR2A Recombinant Antibody; scFv Fragment (HPAB-0134-FY-S(P)) | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0134-FY-F(E) | Mouse Anti-ACVR2A Recombinant Antibody; Fab Fragment (HPAB-0134-FY-F(E)) | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY137 | Anti-ACVR2A Immunohistochemistry Kit | IHC | |
| VS-0525-XY138 | Anti-Human ACVR2A Immunohistochemistry Kit | IHC | |
| VS-0525-XY139 | Anti-Mouse ACVR2A Immunohistochemistry Kit | IHC |
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