Rabbit Anti-ALDH1A1 Recombinant Antibody (VS3-CJ202)
CAT#: VS3-CJ202
This product is a rabbit antibody that recognizes ALDH1A1.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A549
Immunofluorescent staining of human cell line A549 shows localization to cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2123/1584_G10_1_selected.jpg
Normal Tissue
Figure 2 High expression in epididymis
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2123/8966_A_1_6_val_selected.jpg
Normal Tissue
Figure 3 Kidney
Cells in tubules Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/20690/47870_A_7_5.jpg
Normal Tissue
Figure 4 Testis
Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/20690/47870_A_6_6.jpg
Normal Tissue
Figure 5 Stomach
Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/20690/47870_A_3_1.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (A549, Hep G2, RPTEC TERT1)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000165092-ALDH1A1
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Specifications
- Immunogen
- Recombinant protein
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat ALDH1A1
- Species Reactivity
- Human, Mouse, Rat
- Applications
- WB, IHC, IP
- Conjugate
- Unconjugated
Product Property
- Purification
- Protein A affinity purified
- Purity
- >95% as determined by SDS-PAGE
- Buffer
- 40% Glycerol, 1% BSA, TBS, pH7.4.
- Preservative
- 0.05% sodium azide
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- This antibody has been tested for use in Western Blot, Immunohistochemistry, Immunoprecipitation.
Target
- Alternative Names
- ALDC; ALDH1; HEL-9; HEL12; PUMB1; ALDH11; RALDH1; ALDH-E1; HEL-S-53e
- Gene ID
- 216
- UniProt ID
- P00352
- Sequence Similarities
- Belongs to the aldehyde dehydrogenase family.
- Cellular Localization
- Cell projection, Cytoplasm
- Post Translation Modifications
- The N-terminus is blocked most probably by acetylation.
- Protein Refseq
- NP_000680.2
- Function
- Cytosolic dehydrogenase that catalyzes the irreversible oxidation of a wide range of aldehydes to their corresponding carboxylic acid (PubMed:19296407, PubMed:12941160, PubMed:15623782, PubMed:17175089, PubMed:26373694, PubMed:25450233).
Functions downstream of retinol dehydrogenases and catalyzes the oxidation of retinaldehyde into retinoic acid, the second step in the oxidation of retinol/vitamin A into retinoic acid (By similarity).
This pathway is crucial to control the levels of retinol and retinoic acid, two important molecules which excess can be teratogenic and cytotoxic (By similarity).
Also oxidizes aldehydes resulting from lipid peroxidation like (E)-4-hydroxynon-2-enal/HNE, malonaldehyde and hexanal that form protein adducts and are highly cytotoxic. By participating for instance to the clearance of (E)-4-hydroxynon-2-enal/HNE in the lens epithelium prevents the formation of HNE-protein adducts and lens opacification (PubMed:19296407, PubMed:12941160, PubMed:15623782).
Functions also downstream of fructosamine-3-kinase in the fructosamine degradation pathway by catalyzing the oxidation of 3-deoxyglucosone, the carbohydrate product of fructosamine 3-phosphate decomposition, which is itself a potent glycating agent that may react with lysine and arginine side-chains of proteins (PubMed:17175089).
Has also an aminobutyraldehyde dehydrogenase activity and is probably part of an alternative pathway for the biosynthesis of GABA/4-aminobutanoate in midbrain, thereby playing a role in GABAergic synaptic transmission (By similarity).
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "ALDH1A1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0567MZ | Mouse Anti-ALDH1A1 Recombinant Antibody (clone nBcdbn 72304) | WB | Mouse IgG |
| MRO-0049-CN | Mouse Anti-ALDH1A1 Recombinant Antibody (clone 8F1) | WB, IHC | Mouse IgG1 |
| MRO-0050-CN | Rabbit Anti-ALDH1A1 Recombinant Antibody (clone CBACN-019) | WB, IHC, IP | Rabbit IgG |
| MRO-1634-CN | Rabbit Anti-ALDH1A1 Polyclonal Antibody (MRO-1634-CN) | WB, IF, IHC, FC | Rabbit IgG |
| MRO-1635-CN | Rabbit Anti-ALDH1A1 Polyclonal Antibody (MRO-1635-CN) | WB, IF, IHC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0136 | Hi-Affi™ Rabbit Anti-ALDH1A1 Recombinant Antibody (clone DS136AB) | WB, IHC-P | Rabbit IgG |
| MOR-0063-FY | Rabbit Anti-ALDH1A1 Recombinant Antibody (clone AFY0034) | IF, IHC-P, IP, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0924-YC20 | Rabbit Anti-ALDH1A1 Antibody (VS-0924-YC20) - Cancer Stem Cell Marker | IHC, WB, IF | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY87 | Anti-ALDH1A1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY292 | Anti-Human ALDH1A1 Immunohistochemistry Kit | IHC |
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