Rabbit Anti-ALDH7A1 Recombinant Antibody (VS13-YC43) (CAT#: VS13-YC43)
The Rabbit Anti-ALDH7A1 Recombinant Antibody is specific for human and mouse ALDH7A1. ALDH7A1, part of the aldehyde dehydrogenase family, is key in detoxifying aldehydes and lysine catabolism, existing both in cytosol and mitochondria due to alternate translation sites. Mutations here link to pyridoxine-dependent epilepsy, and several pseudogenes are known. The anti-ALDH7A1 antibody can be used for Western blot (1/500-1/1000), Immunofluorescence (1/50-1/200), Immunoprecipitation (1/20).
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to mitochondria.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/23296/if_selected.jpg
(Immunofluorescent staining of human cell line A-431 shows localization to mitochondria.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/23296/if_selected.jpg
Figure 2 Cerebral cortex
(Glial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuropil Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/53675/169819_B_7_5.jpg
(Glial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuropil Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/53675/169819_B_7_5.jpg
Figure 3 Colon
(Enterocytes Staining: Low Intensity: Moderate Quantity: <25% Enterocytes - Mucosal lymphoid cells Staining: Low Intensity: Moderate Quantity: <25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/53675/169819_A_8_3.jpg
(Enterocytes Staining: Low Intensity: Moderate Quantity: <25% Enterocytes - Mucosal lymphoid cells Staining: Low Intensity: Moderate Quantity: <25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/53675/169819_A_8_3.jpg
Figure 4 Liver
(Cholangiocytes Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Hepatocytes Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/53675/169819_A_8_4.jpg
(Cholangiocytes Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Hepatocytes Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/53675/169819_A_8_4.jpg
Figure 5 Testis
(Cells in seminiferous ducts Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous nuclear Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/53675/169819_A_4_6.jpg
(Cells in seminiferous ducts Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous nuclear Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/53675/169819_A_4_6.jpg
Figure 6 Lymph node
(Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/53675/169819_A_9_8.jpg
(Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/53675/169819_A_9_8.jpg
Figure 7 RNA cell line category: Cell line enhanced (HBEC3-KT)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000164904-ALDH7A1
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000164904-ALDH7A1
Specifications
- Immunogen
- Recombinant human ALDH7A1.
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human and Mouse ALDH7A1
- Species Reactivity
- Human, Mouse
- Applications
- WB, ICC, IF, IP
- Conjugate
- NONE
- Related Disease
- Epilepsy, Early-Onset, Vitamin B6-Dependent and Hydrocephalus, Congenital
Product Property
- Clonality
- Monoclonal
- Purification
- Affinity Chromatography purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- 50 mM Tris-Glycine (pH 7.4) containing 150 mM NaCl, 40% Glycerol and 0.05% BSA.
- Preservative
- 0.01% Sodium azide
- Storage
- Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Shipping with ice pack.
Applications
- Application Notes
- Western blot (WB): 1/500-1/1000
Immunofluorescence (IF): 1/50-1/200
Immunoprecipitation (IP): 1/20
Target
- Alternative Names
- Aldehyde Dehydrogenase 7 Family Member A1; Alpha-AASA Dehydrogenase; P6c Dehydrogenase; Delta1-Piperideine-6-Carboxylate Dehydrogenase; Alpha-Aminoadipic Semialdehyde Dehydrogenase; Betaine Aldehyde Dehydrogenase; 26g Turgor Protein Homolog; Antiquitin-1; ATQ1; Delta1-Piperideine-6-Carboxylate Dehydrogenease;
- Gene ID
- 501
- UniProt ID
- P49419
- Long Name
- Aldehyde Dehydrogenase 7 Family Member A1
- Sequence Similarities
- Belongs to the aldehyde dehydrogenase family.
- Cellular Localization
- Cytoplasm; Mitochondrion; Nucleus
- Protein Refseq
- NP_001173.2; NP_001188306.1; NP_001189333.2
- Function
- Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism.
Recommended Products
Secondary Antibody
Isotype Control
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Rabbit Monoclonal Antibody Products
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Antibody Magnetic Beads
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0143 | Hi-Affi™ Rabbit Anti-ALDH7A1 Recombinant Antibody (clone DS143AB) | WB, IHC | Rabbit IgG |
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