Rabbit Anti-ATM Recombinant Antibody (clone R07-5J6)
CAT#: VS3-XY3271
This product is a recombinant rabbit antibody specific for ATM (ATM serine/threonine kinase), which involves in pexophagy by mediating phosphorylation of PEX5. It recognizes and binds to human ATM. It also has cross-reactivity against mouse and rat ATM. It has been tested using Western Blot, Immunoprecipitation, Flow cytometry, Immunocytochemistry or Immunofluorescence.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human kidney
Immunohistochemical staining of human kidney shows strong nuclear positivity in tubules and glomeruli.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/102/2822_A_9_5_selected.jpg
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Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat ATM
- Species Reactivity
- Human, Mouse, Rat
- Clone
- R07-5J6
- Applications
- WB, ICC, IF, IP, FC
- Related Disease
- Ataxia-Telangiectasia; Mantle Cell Lymphoma
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- WB: 1/500-1/1000
IF: 1/50-1/200
IP: 1/20
FC: 1/50-1/100
Target
- Alternative Names
- AT1; ATA; ATC; ATD; ATE; ATDC; TEL1; TELO1
- Gene ID
- 472
- UniProt ID
- Q13315
- Long Name
- ATM serine/threonine kinase
- Cellular Localization
- Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Nucleus, Peroxisome
- Post Translation Modifications
- Phosphorylated by NUAK1/ARK5.
Acetylation, on DNA damage, is required for activation of the kinase activity, dimer-monomer transition, and subsequent autophosphorylation on Ser-1981.
Acetylated in vitro by KAT5/TIP60.
Deacetylated by SIRT7 during the late stages of DNA damage response, promoting ATM dephosphorylation and subsequent deactivation.
- Protein Refseq
- XP_006718906.1; XP_005271619.2
- Function
- Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele.
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Related Diseases
Gastric Cancer
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Isotype Control
- CAT
- Product Name
Recommended Dilution Buffer
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "ATM"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0059MZ | Chicken Anti-ATM Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0286 | Hi-Affi™ Rabbit Anti-ATM Recombinant Antibody (clone DS286AB) | IF, IHC-P, IP, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-QX82 | Mouse Anti-ATM Recombinant Antibody (clone 7C3-3A2-5D1) | IHC | Mouse IgG1 |
| VS3-QX83 | Mouse Anti-ATM Recombinant Antibody (clone 8G1-7B2-3E1) | IHC | Mouse IgG1 |
| VS3-QX84 | Mouse Anti-ATM Recombinant Antibody (clone 9E1-10B9-1E4) | IHC | Mouse IgG1 |
| VS3-QX85 | Mouse Anti-ATM Recombinant Antibody (clone 10G6-10G10-1G8) | IHC | Mouse IgG1 |
| VS3-QX86 | Mouse Anti-ATM Recombinant Antibody (clone 9D10-1A10-6A4) | IHC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY24 | AbPlus™ Anti-ATM Magnetic Beads (4E11) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY36 | Mouse Anti-NHP ATM Recombinant Antibody (clone 2C1) | WB, IHC, IP | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY197 | Anti-ATM Immunohistochemistry Kit | IHC | |
| VS-0525-XY599 | Anti-Mouse ATM Immunohistochemistry Kit | IHC | |
| VS-0525-XY598 | Anti-Human ATM Immunohistochemistry Kit | IHC |
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