Human Anti-B. anthracis PA Recombinant Antibody (clone 83K7C) (CAT#: FAMAB-0048JF)
Recombinant monoclonal antibody specially binds to anthrax toxin. This anti-anthrax toxin antibody 83K7C has therapeutic value in human with anthrax infection.
Specific Inquiry
FC
Figure 1 Analysis of IgG clones selected from the anti-PA library.
Flow cytometry histogram depicting the fluorescence intensity of E. coli clones expressing anti-PA IgG antibodies and labeled with PA-FITC.
Schumacher, W. C., Storozuk, C. A., Dutta, P. K., & Phipps, A. J. (2008). Identification and characterization of Bacillus anthracis spores by multiparameter flow cytometry. Applied and environmental microbiology, 74(16), 5220-5223.
Neut
Figure 2 The graph shows the association between toxin-neutralising antibody titres (x-axis) and protective antigen.
The horizontal dashed lines indicate cut-off values for PA- and LF-specific immunoglobulin levels that discriminate between samples positive or negative for toxin-neutralising antibodies, as determined by receiver operator curve analysis.
Grunow, R., Porsch-Özcürümez, M., Splettstoesser, W., Buckendahl, A., Hahn, U., Beyer, W., ... & Frangoulidis, D. (2007). Monitoring of ELISA-reactive antibodies against anthrax protective antigen (PA), lethal factor (LF), and toxin-neutralising antibodies in serum of individuals vaccinated against anthrax with the PA-based UK anthrax vaccine. Vaccine, 25(18), 3679-3683.
ELISA
Figure 3 The graph shows the time course of toxin-neutralising antibody titres, protective antigen-specific immunoglobulins.
The time frame and median of the corresponding blood samples are shown on the x-axis.
Grunow, R., Porsch-Özcürümez, M., Splettstoesser, W., Buckendahl, A., Hahn, U., Beyer, W., ... & Frangoulidis, D. (2007). Monitoring of ELISA-reactive antibodies against anthrax protective antigen (PA), lethal factor (LF), and toxin-neutralising antibodies in serum of individuals vaccinated against anthrax with the PA-based UK anthrax vaccine. Vaccine, 25(18), 3679-3683.
IHC
Figure 4 Abundant immunohistochemical staining of granular and bacilliform antigens were demonstrated in the dermis by using anti-B. anthracis cell wall antibody.
Original magnifications: ×100.
Shieh, W. J., Guarner, J., Paddock, C., Greer, P., Tatti, K., Fischer, M., ... & Popovic, T. (2003). The critical role of pathology in the investigation of bioterrorism-related cutaneous anthrax. The American journal of pathology, 163(5), 1901-1910.
Specifications
- Immunogen
- Anthrax
- Host Species
- Human
- Derivation
- Human phage display Fab library
- Type
- Human IgG
- Specificity
- Bacillus anthracis PA83
- Species Reactivity
- B. anthracis
- Clone
- 83K7C
- Applications
- ELISA, Neut, IHC, FC
- Related Disease
- Anthrax
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The B. anthracis PA antibody has been reported in applications of Enzyme-linked Immunosorbent Assay, Neutralization, Flow Cytometry, Immunohistochemistry.
Target
- Alternative Names
- PA; PA83; Pag; PagA; Protective antigen; Bacillus anthracis; B. anthracis
- Function
- Neutralization
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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See other products for "Clone 83K7C"
See other products for "B. anthracis PA"
Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-194-VHH | Recombinant Anti-B. anthracis PA VHH Single Domain Antibody | WB, ICC, ChiP, FA, ELISA | Llama VHH |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-97-S(P) | Recombinant Anti-B. anthracis PA Antibody scFv Fragment | WB, FC, FuncS | scFv |
| MHH-97-S(P) | Recombinant Human Anti-B. anthracis PA Antibody scFv Fragment | Neut, WB, FuncS | scFv |
| HPAB-0747-YJ-S(P) | Chimpanzee Anti-PA Recombinant Antibody (W1); scFv Fragment | ELISA, Neut | Chimpanzee scFv |
| FAMAB-0223JF-S(P) | Monkey Anti-B. anthracis PA Recombinant Antibody (clone 35PA83); scFv Fragment | ELISA, FuncS | Monkey scFv |
| FAMAB-0333JF-S(P) | Human Anti-B. anthracis PA Recombinant Antibody (clone 001.46F1); scFv Fragment | ELISA, FuncS | Human scFv |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-224 | Anti-B. Anthracis Anthrax Protective Antigen (Raxibacumab) | FC, IP, ELISA, Neut, FuncS, IF, WB | IgG1 - lambda |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-97 | Recombinant Human Anti-B. anthracis PA Antibody | Neut, IF, FuncS | IgG |
| MRO-513-MZ | Mouse Anti-B. anthracis PA Recombinant Antibody (clone 7825) | ELISA | Mouse IgG |
| HPAB-0780-CN | Mouse Anti-B. anthracis PA Recombinant Antibody (HPAB-0780-CN) | ELISA, Neut | Mouse IgG1, κ |
| HPAB-0781-CN | Mouse Anti-B. anthracis PA Recombinant Antibody (HPAB-0781-CN) | ELISA, Neut | Mouse IgG1, κ |
| HPAB-1646-FY | Human Anti-B. anthracis PA Recombinant Antibody (HPAB-1646-FY) | Neut, ELISA, Inhib | Human IgG |
Epitope-Specific Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| EPAF-0387LC | Recombinant Mouse Anti-B. anthracis PA Antibody (F20G75) | BL, ELISA | IgG1 |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0780-CN-F(E) | Mouse Anti-B. anthracis PA Recombinant Antibody; Fab Fragment (HPAB-0780-CN-F(E)) | ELISA, Neut | Mouse Fab |
| HPAB-1824-FY-S(P) | Human Anti-B. anthracis PA Recombinant Antibody (clone 21D9); Fab Fragment | ELISA | Human Fab |
| HPAB-1825-FY-S(P) | Human Anti-B. anthracis PA Recombinant Antibody (clone 1C6); Fab Fragment | ELISA | Human Fab |
| HPAB-1826-FY-S(P) | Human Anti-B. anthracis PA Recombinant Antibody (clone 4H7); Fab Fragment | ELISA | Human Fab |
| FAMAB-0048JF-F(E) | Human Anti-B. anthracis PA Recombinant Antibody (clone 83K7C); Fab Fragment | WB, ELISA, FuncS | Human Fab |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-224 | Afuco™ Anti-B. anthracis PA ADCC Recombinant Antibody (Raxibacumab), ADCC Enhanced | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
| AFC-TAB-440CQ | Afuco™ Anti-PA ADCC Recombinant Antibody (Obiltoxaximab), ADCC Enhanced | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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