AbPlus™ Anti-BCL2L1 Magnetic Beads (VS-0724-YC1434)
CAT#: VS-0724-YC1434
The AbPlus Anti-BCL2L1 Magnetic Beads (VS-0724-YC1434) is an innovative affinity resin which is bound with anti-BCL2L1 specific antibody. The beads were designed for small-scale affinity purification and immunoprecipitation (IP) of BCL2L1 protein under native and denaturing conditions.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line MCF7
Immunofluorescent staining of human cell line MCF7 shows localization to mitochondria.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/72801/1349_F9_5_selected.jpg
Normal Tissue
Figure 2 IHC staining of human urinary bladder
Immunohistochemical staining of human urinary bladder shows moderate cytoplasmic positivity in urothelial cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35734/ihc_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35734/143255_B_8_5.jpg
Normal Tissue
Figure 4 Liver
Hepatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35734/143255_A_9_4.jpg
Normal Tissue
Figure 5 Kidney
Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35734/143255_A_8_5.jpg
Normal Tissue
Figure 6 Testis
Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35734/143255_A_6_6.jpg
Normal Tissue
Figure 7 Lymph node
Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35734/143255_A_8_8.jpg
RNA Expression
Figure 8 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000171552-BCL2L1
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Specifications
- Applications
- Immunoprecipitation, Protein Purification
- Matrix
- Magnetic bead
- Bead Ligand
- Anti-BCL2L1 specific antibody
- Target
- BCL2L1
- Immunogen
- Recombinant human BCL2L1/Bcl-XL, aa 1-212.
- Target Species
- Human
- Bead Capacity
- 40 mg/mL
- Bead size
- 25 μm
- Format
- Suspension
- Concentration
- 2 mg/mL
- Buffer
- PBS, pH 7.4
- Preservative
- 0.1% Sodium azide
- Storage
- Stored at 4°C, and is stable for up to 2 years. Do not centrifuge, dry or freeze the magnetic beads.
Applications
- Application Notes
- The beads are in suspension and will settle upon storage. Prior to use, mix the vial gently (do not vortex) to ensure delivery of proper bead volume.
Target
- Introduction
- The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Alternative splicing results in multiple transcript variants encoding two different isoforms. The longer isoform acts as an apoptotic inhibitor and the shorter isoform acts as an apoptotic activator. [provided by RefSeq, Dec 2015]
- Alternative Names
- BCL2 Like 1; Protein Phosphatase 1, Regulatory Subunit 52; Apoptosis Regulator Bcl-X; BCL2L; BCLX; Bcl-2-Like Protein 1;
- Gene ID
- 598
- UniProt ID
- Q07817
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Related Diseases
Amyotrophic Lateral Sclerosis
Downloadable Resources
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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| CAT | Product Name | Application | Type |
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| MHC-CN0425 | PE-A*02:01/Human BCL2L1 (YLNDHLEPWI) MHC Tetramer | FCM, IHC | |
| MHC-CN0426 | APC-A*02:01/Human BCL2L1 (YLNDHLEPWI) MHC Tetramer | FCM, IHC | |
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| MHC-CN0428 | A*02:01/Human BCL2L1 (YLNDHLEPWI) MHC Tetramer | FCM, IHC | |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC1435 | AbPlus™ Anti-Bcl2l1 Magnetic Beads (VS-0724-YC1435) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
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| VS-0525-XY734 | Anti-Porcine BCL2L1 Immunohistochemistry Kit | IHC |
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| VS13-YC97 | CytoStream™ Rabbit Anti-BCL2L1 Recombinant Antibody (VS13-YC97) | WB, ICC, IF, IHC-P, FC, IP | Rabbit IgG |
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