Anti-BCR Antibody Prodrug, Protease Activated (VS-1025-YC65)
CAT#: VS-1025-YC65
The Anti-BCR Antibody Prodrug, Protease Activated (VS-1025-YC65) is an antibody prodrug comprised of a recombinant human antibody targeting human BCR, linked to a masking peptide that conceals the active antigen-binding site via a protease-cleavable linker. The mask peptide is recombinantly attached to the amino terminus of either the light or heavy chain of the antibody, designed to block access to the antigen-binding site and physically prevent the antibody from binding to BCR protein. Once the masking peptide is cleaved by matrix metalloproteinases (MMPs), the prodrug is activated, allowing the unmasked monoclonal antibody component to bind to BCR effectively. BCR (Breakpoint Cluster Region) is a gene that forms a famous fusion oncogene with the ABL tyrosine kinase, known as BCR-ABL, which is the hallmark of Chronic Myeloid Leukemia (CML). The resulting fusion protein is a constitutively active tyrosine kinase that drives the malignant phenotype. This finding led to the development of the successful targeted TKI, imatinib.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm, plasma membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/38337/431_D1_2_selected.jpg
Normal Tissue
Figure 2 IHC staining of human kidney
Immunohistochemical staining of human kidney shows membranous and cytoplasmic positivity in cells in tubules.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/38337/ihc_selected.jpg
Normal Tissue
Figure 3 IHC staining of human cerebellum
Immunohistochemical staining of human cerebellum shows strong cytoplasmic positivity in Purkinje cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/18545/ihc_selected.jpg
Normal Tissue
Figure 4 Cerebral cortex
Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Neuropil
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/38337/81435_B_8_5.jpg
Normal Tissue
Figure 5 Colon
Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Peripheral nerve/ganglion
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/38337/81435_A_8_3.jpg
Normal Tissue
Figure 6 Kidney
Cells in tubules
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/38337/81435_A_8_5.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (K-562)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000186716-BCR
❮
❯
Specifications
- Host Animal
- Human
- Applications
- In situ zymography (ISZ), Cytotoxicity assay (Cyt), Functional assay
- Specificity
- Human BCR
- Target
- BCR
- Species Reactivity
- Human
- Isotype
- Chimeric (mouse/human) IgG
- Masking Approach
- Affinity mask
- Mask
- A synthetic peptide
- Protease Cleavable Linker
- MMP-cleavable linker
- Protease Substrate
- MMPs
- Purification
- Protein A purified
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Target
- Introduction
- A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene.
- Alternative Names
- EC 2.7.11.1; D22S11; BCR1; BCR/FGFR1 Chimera Protein; FGFR1/BCR Chimera Protein; D22S662; ALL; CML; PHL
- Gene ID
- 613
- UniProt ID
- P11274
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for VS-1025-YC65. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Related Diseases
Asthma
Systemic Lupus Erythematosus
Allograft Rejection
Autoimmune Thyroid Disease
Amyotrophic Lateral Sclerosis
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "BCR"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-104 | Recombinant Anti-BCR Antibody | ELISA, WB, IP, FuncS | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-104-F(E) | Recombinant Anti-BCR Antibody Fab Fragment | WB, IF, FuncS | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-104-S(P) | Recombinant Anti-BCR Antibody scFv Fragment | ELISA, WB, IP, FuncS | scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-104 | Recombinant Human Anti-BCR Antibody | ELISA, IP, FuncS | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-104-F(E) | Recombinant Human Anti-BCR Antibody Fab Fragment | ELISA, WB, Dot, FuncS | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-104-S(P) | Recombinant Human Anti-BCR Antibody scFv Fragment | ELISA, IP, FuncS | scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-G001E | Anti-BCR immunotoxin (scFv)-PE | Cytotoxicity assay, Function study |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1235CL | Human Anti-BCR Recombinant Antibody (TAB-1235CL) | ELISA | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1236CL | Human Anti-BCR Recombinant Antibody (TAB-1236CL) | ELISA | Humanized IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1237CL | Human Anti-BCR Recombinant Antibody (TAB-1237CL) | ELISA | Chimeric IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1238CL | Human Anti-BCR Recombinant Antibody (TAB-1238CL) | ELISA | Humanized IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1239CL | Human Anti-BCR Recombinant Antibody (TAB-1239CL) | ELISA | Humanized IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1240CL | Human Anti-BCR Recombinant Antibody (TAB-1240CL) | ELISA | Humanized IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1241CL | Human Anti-BCR Recombinant Antibody (TAB-1241CL) | ELISA | Humanized IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1235CL-S(P) | Human Anti-BCR Recombinant Antibody; scFv Fragment (TAB-1235CL-S(P)) | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1237CL-S(P) | Mouse Anti-BCR Recombinant Antibody; scFv Fragment (TAB-1237CL-S(P)) | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1235CL-F(E) | Human Anti-BCR Recombinant Antibody; Fab Fragment (TAB-1235CL-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1237CL-F(E) | Human Anti-BCR Recombinant Antibody; Fab Fragment (TAB-1237CL-F(E)) | ELISA | Chimeric Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0349 | Hi-Affi™ Rabbit Anti-BCR Recombinant Antibody (clone DS349AB) | FC, ICC, IHC-P, IP, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0267-YC | Human Anti-BCR Recombinant Antibody (HPAB-0267-YC) | ELISA | Chimeric (mouse/human) IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0268-YC | Human Anti-BCR Recombinant Antibody (HPAB-0268-YC) | ELISA | Humanized IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0267-YC-S(P) | Human Anti-BCR Recombinant Antibody; scFv Fragment (HPAB-0267-YC-S(P)) | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0268-YC-S(P) | Human Anti-BCR Recombinant Antibody; scFv Fragment (HPAB-0268-YC-S(P)) | ELISA | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0267-YC-F(E) | Human Anti-BCR Recombinant Antibody; Fab Fragment (HPAB-0267-YC-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0268-YC-F(E) | Human Anti-BCR Recombinant Antibody; Fab Fragment (HPAB-0268-YC-F(E)) | ELISA | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-WK119 | Mouse Anti-BCR Recombinant Antibody (clone G12-E11) | WB, ELISA | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY236 | Anti-BCR Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY750 | Anti-Human BCR Immunohistochemistry Kit | IHC |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: ELISA, IP, FC, FuncS, Neut, IF, ICC
Application: Neut, ELISA, IF, IP, FuncS, FC, ICC
Application: FuncS, IF, Neut, ELISA, FC, IP, ICC
Application: WB, FC, IP, ELISA, Neut, FuncS, IF
Application: Neut, ELISA, IF, IP, FuncS, FC, ICC
Application: Neut, ELISA, IF, IP, FuncS, FC, ICC
Application: IF, IP, Neut, FuncS, ELISA, FC, WB
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
Application: Neut, ELISA, IF, IP, FuncS, FC, ICC
Application: FuncS, IF, Neut, ELISA, FC, IP, ICC
Application: FuncS, IF, Neut, ELISA, FC, IP, ICC
Application: FC, IP, ELISA, Neut, FuncS, IF, ICC
Application: Block, Cyt, FuncS, Inhib
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
