Mouse Anti-C3AR1 Recombinant Antibody (clone 2A1)
CAT#: FAMAB-0111JF
Recombinant mouse monoclonal antibody binds to the second extracellular loop of the human C3a receptor (2e loop). This anti-C3a antibody (2A1) can be useful in the study of immune processes of arthritis, diet-induced obesity and cancers.
Published Data
Gene Expression
IHC
Figure 1 Spinal localization of C3aR1.
Scale bars: I, 100 μm; I1–4, 50 μm.
Matsumoto, N., Satyam, A., Geha, M., Lapchak, P. H., Dalle Lucca, J. J., Tsokos, M. G., & Tsokos, G. C. (2017). C3a enhances the formation of intestinal organoids through C3aR1. Frontiers in immunology, 8, 1046.
WB
Figure 2 Protein expression of Ki67 and Lgr5 were compared in organoids by western blotting in the absence or presence of C3a in the medium.
β-actin was used as a protein loading control (n = 3 mice in each group).
Matsumoto, N., Satyam, A., Geha, M., Lapchak, P. H., Dalle Lucca, J. J., Tsokos, M. G., & Tsokos, G. C. (2017). C3a enhances the formation of intestinal organoids through C3aR1. Frontiers in immunology, 8, 1046.
FuncS
Figure 3 C3a promotes organoid formation.
The number of organoids formed in wells 7 days were counted after the initiation of culture under various conditions.
Matsumoto, N., Satyam, A., Geha, M., Lapchak, P. H., Dalle Lucca, J. J., Tsokos, M. G., & Tsokos, G. C. (2017). C3a enhances the formation of intestinal organoids through C3aR1. Frontiers in immunology, 8, 1046.
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Normal Tissue
Figure 1 Lymph node
Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/9405/31528_A_7_8.jpg
RNA Expression
Figure 2 RNA cell line category: Cell line enriched (HMC-1)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000171860-C3AR1
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Specifications
- Immunogen
- Second extracellular loop of the C3aR
- Host Species
- Mouse
- Derivation
- Human phage display scFv library
- Type
- Mouse IgG
- Specificity
- Human C3AR1
- Species Reactivity
- Human
- Clone
- 2A1
- Applications
- WB, IHC, FuncS
- Related Disease
- Arthritis, diet-induced obesity, cancers
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The C3AR1 antibody has been reported in applications of Western Blot, Immunohistochemistry, Functional Assay.
Target
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
See other products for "Clone 2A1"
- CAT
- Product Name
See other products for "C3AR1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1858z | Mouse Anti-C3AR1 Recombinant Antibody (clone 25H10) | ELISA, FC | Mouse IgG1, κ |
| MOB-0279CT | Mouse Anti-C3AR1 Recombinant Antibody (clone 85) | FC, IHC-Fr | Mouse IgG1 |
| FAMAB-0110JF | Mouse Anti-C3AR1 Recombinant Antibody (clone 3G7) | IHC, FC | Mouse IgG |
| VS7-HM278 | Mouse Anti-C3AR1 Recombinant Antibody (clone 3B5E1) | FCM | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0110JF-F(E) | Mouse Anti-C3AR1 Recombinant Antibody (clone 3G7); Fab Fragment | FACS, ELISA, FuncS | Mouse Fab |
| FAMAB-0111JF-F(E) | Mouse Anti-C3AR1 Recombinant Antibody (clone 2A1); Fab Fragment | FACS, ELISA, FuncS | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0110JF-S(P) | Mouse Anti-C3AR1 Recombinant Antibody (clone 3G7); scFv Fragment | FACS, ELISA, FuncS | Mouse scFv |
| FAMAB-0111JF-S(P) | Mouse Anti-C3AR1 Recombinant Antibody (clone 2A1); scFv Fragment | FACS, ELISA, FuncS | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC750 | Recombinant Anti-C3AR1 Vesicular Antibody, EV Displayed (VS-0425-YC750) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY881 | Anti-Mouse C3AR1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY882 | Anti-Rat C3AR1 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC24 | Recombinant Anti-C3AR1 (AA 185-193 x AA 218-226) Biparatopic Antibody, Tandem scFv (Clone 3G7 x Clone 2A1) | IHC | Tandem scFv |
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