Mouse Anti-CAPN2 Recombinant Antibody (VS3-FY2643) (CAT#: VS3-FY2643)

• Host Species
• Mouse

• Type
• Mouse IgG

• Specificity
• Calpain 2 of human and mouse origins

• Species Reactivity
• Human, Mouse

• Applications
• WB, IHC, FC

• Conjugate
• Unconjugated, FITC

• MW
• The molecular weight of the target protein is approximately 80.0 kDa.

• Related Disease
• Alzheimer's disease

• Clonality
• Monoclonal Antibody

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• Western Blot: 1/500-1/1000
  Immunohistochemistry: 1/50-1/200
  Flow cytometry: 1/50-1/100

• Alternative Names
• Calpain 2; Calcium-Activated Neutral Proteinase 2; Calpain 2, (M/II) Large Subunit; Millimolar-Calpain; Calpain M-Type; EC 3.4.22.53; M-Calpain; CANP 2; CANPL2; Calpain 2, Large [Catalytic] Subunit

• Gene ID
• 824

• UniProt ID
• P17655

• Sequence Similarities
• Belongs to the peptidase C2 family.

• Cellular Localization
• Cytoplasm
  Cell membrane

• Post Translation Modifications
• Ubiquitination at Lys26, Lys260, Lys476, and Lys674
  Modification sites at PhosphoSitePlus
  Glycosylation from GlyGen 1 site, 1 O-linked glycan (1 site)

• Protein Refseq
• XP_047287300.1; XP_054194910.1; NP_001139540.1; NP_001739.3

• Function
• Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.
  Proteolytically cleaves MYOC at 'Arg-226'

Secondary Antibody

• 2ND-040CQ
• Goat Anti-Mouse IgG (H&L) Antibody

Isotype Control

• MRO-A1591-YJ
• Mouse IgG Isotype control, Polyclonal

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