Rabbit Anti-CASP10 Recombinant Antibody (clone R03-3B2)
CAT#: VS3-XY3288
The product is a recombinant rabbit antibody binding with CASP10 (Caspase 10), which involves in the activation cascade of caspases responsible for apoptosis execution. It recognizes and binds to human CASP10. It also has cross-reactivity against mouse CASP10. It has been tested using Western Blot, Immunohistochemistry-Paraffin, Immunoprecipitation, Flow cytometry, Immunocytochemistry or Immunofluorescence.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line Hep G2
Immunofluorescent staining of human cell line Hep G2 shows localization to the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/17059/1404_C2_1_selected.jpg
Normal Tissue
Figure 2 Lymph node
Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/17059/40550_A_7_8.jpg
Normal Tissue
Figure 3 Colon
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/17059/40550_A_7_3.jpg
Normal Tissue
Figure 4 Kidney
Cells in tubules Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/17059/40550_A_7_5.jpg
Normal Tissue
Figure 5 Testis
Cells in seminiferous ducts Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Leydig cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/17059/40550_A_5_6.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (HUVEC TERT2)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000003400-CASP10
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Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human and Mouse CASP10
- Species Reactivity
- Human, Mouse
- Clone
- R03-3B2
- Applications
- WB, IHC-P, ICC, IF, IP, FC
- Related Disease
- Autoimmune lymphoproliferative syndrome 2A (ALPS2A); Familial non-Hodgkin lymphoma (NHL); Gastric cancer (GASC)
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- WB: 1/500-1/1000
IHC: 1/50-1/100
IF: 1/50-1/200
IP: 1/20
FC: 1/50-1/100
Target
- Alternative Names
- MCH4; ALPS2; FLICE2; FLICE-2
- Gene ID
- 843
- UniProt ID
- Q92851
- Long Name
- Caspase 10
- Cellular Localization
- Cytoplasm
- Post Translation Modifications
- Cleavage by granzyme B and autocatalytic activity generate the two active subunits.
- Protein Refseq
- XP_005246964.1
- Function
- Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates effector caspases CASP3, CASP4, CASP6, CASP7, CASP8 and CASP9.
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Related Signaling Pathways
TNF Signaling Pathway
Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Isotype Control
- CAT
- Product Name
Recommended Dilution Buffer
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "CASP10"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2489z | Mouse Anti-CASP10 Recombinant Antibody (clone 42G5) | WB, ELISA, IF, IP | Mouse IgM, κ |
| MOB-0324CT | Mouse Anti-CASP10 Recombinant Antibody (clone 3F8) | ELISA, WB | Mouse IgG2a |
| MRO-0238-CN | Rabbit Anti-CASP10 Recombinant Antibody (clone CBACN-087) | WB, IHC, IP, FC | Rabbit IgG |
| VS3-WK1089 | Rabbit Anti-CASP10 Recombinant Antibody (VS3-WK1089) | WB, IHC, IP, FC | Rabbit IgG |
| VS3-WK1582 | Rabbit Anti-CASP10 Recombinant Antibody (VS3-WK1582) | WB, ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0472 | Hi-Affi™ Rabbit Anti-CASP10 Recombinant Antibody (clone DS472AB) | FC, IF, IHC-P, IP, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS13-YC124 | CytoStream™ Rabbit Anti-CASP10 Recombinant Antibody (VS13-YC124) | WB, IHC-P, FC, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY994 | Anti-CASP10 Immunohistochemistry Kit | IHC |
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