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  • Rabbit Anti-CASP2 Recombinant Antibody (VS3-CJ957)

Rabbit Anti-CASP2 Recombinant Antibody (VS3-CJ957) (CAT#: VS3-CJ957)

This product is a rabbit antibody that recognizes human, mouse, and rat CASP2.


See more Engineered Antibody products for CASP2
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  • Gene Expression
  • Datasheet
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  • COA
Subcellular Location
Figure 1 IF staining of human cell line A-431
Figure 1 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/50678/if_selected.jpg
Normal Tissue
Figure 2 IHC staining of human placenta
Figure 2 IHC staining of human placenta
(Immunohistochemical staining of human placenta shows strong cytoplasmic positivity in decidual cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/50678/ihc_selected.jpg
Figure 3 Lymph node
Figure 3 Lymph node
(Germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Nuclear Non-germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/50678/123280_A_7_8.jpg
Figure 4 Cerebral cortex
Figure 4 Cerebral cortex
(Endothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Neuronal cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuropil Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/50678/123280_B_8_5.jpg
Figure 5 Small intestine
Figure 5 Small intestine
(Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/50678/123280_A_4_2.jpg
Figure 6 Colon
Figure 6 Colon
(Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/50678/123280_A_7_3.jpg
Figure 7 Liver
Figure 7 Liver
(Cholangiocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/50678/123280_A_7_4.jpg
Figure 8 Kidney
Figure 8 Kidney
(Cells in glomeruli Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Cells in tubules Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/50678/123280_A_7_5.jpg
Figure 9 Testis
Figure 9 Testis
(Leydig cells Staining: High Intensity: Strong Quantity:>75% Sertoli cells Staining: Low Intensity: Moderate Quantity: <25% Spermatogonia cells Staining: Low Intensity: Moderate)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/50678/123280_A_5_6.jpg
RNA Expression
Figure 10 RNA cell line category: Low cell line specificity
Figure 10 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000106144-CASP2

Specifications

  • Immunogen
  • Recombinant protein
  • Host Species
  • Rabbit
  • Type
  • Rabbit IgG
  • Specificity
  • Human, Mouse, Rat CASP2
  • Species Reactivity
  • Human, Mouse, Rat
  • Applications
  • WB, ICC, IF, IHC, FC
  • Conjugate
  • Unconjugated

Product Property

  • Purification
  • Protein A affinity purified
  • Purity
  • >95% as determined by SDS-PAGE
  • Format
  • Liquid
  • Buffer
  • 40% Glycerol, 1% BSA, TBS, pH7.4.
  • Preservative
  • 0.05% Sodium Azide
  • Storage
  • Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.

Applications

  • Application Notes
  • This antibody has been tested for use in Western Blot, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Flow Cytometry.

Target

  • Alternative Names
  • ICH1; NEDD2; CASP-2; NEDD-2; PPP1R57
  • Sequence Similarities
  • Belongs to the peptidase C14A family.
  • Cellular Localization
  • Cytoplasm, Cytosol, Mitochondrion, Nucleus
  • Post Translation Modifications
  • The mature protease can process its own propeptide, but not that of other caspases.
  • Function
  • Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival (PubMed:15073321).
    Associates with PIDD1 and CRADD to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis in response to genotoxic stress (PubMed:15073321).

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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "CASP2"

Recombinant Antibody

CAT Product Name Application Type
MOB-0326CT Mouse Anti-CASP2 Recombinant Antibody (clone 5j24) WB Mouse IgG1
MRO-0240-CN Rabbit Anti-CASP2 Recombinant Antibody (clone CBACN-089) WB, IF, IHC, FC Rabbit IgG
ZG-0579J Rabbit Anti-CASP2 Recombinant Antibody (clone 7E5) ELISA, WB Rabbit IgG
ZG-0102U Rabbit Anti-CASP2 Recombinant Antibody (clone 3D4) ELISA, WB, IHC Rabbit IgG

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-0474 Hi-Affi™ Rabbit Anti-CASP2 Recombinant Antibody (clone DS474AB) IP, WB Rabbit IgG

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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