Human Anti-CCR4 Recombinant Antibody Hexamer (VS-0924-YC106), CDC Enhanced
CAT#: VS-0924-YC106
The product is a human anti-CCR4 antibody hexamer with enhanced CDC activity. This hexameric IgG1 targets human CCR4 and includes mutations that promote hexamer formation. These mutations enhance C1q binding and increase complement-dependent cytotoxicity (CDC).
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/31613/329_F5_2_selected.jpg
Normal Tissue
Figure 2 IHC staining of human tonsil
Immunohistochemical staining of human tonsil shows strong cytoplasmic positivity in a subset of cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/31613/ihc_selected.jpg
Normal Tissue
Figure 3 Colon
Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/31613/68832_A_8_3.jpg
Normal Tissue
Figure 4 Testis
Leydig cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/31613/68832_A_4_6.jpg
Normal Tissue
Figure 5 Lymph node
Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/31613/68832_A_9_8.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enriched (HDLM-2)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000183813-CCR4
❮
❯
Specifications
- Host Species
- Human
- Derivation
- Humanized
- Type
- Antibody hexamer
- Specificity
- Human CCR4
- Species Reactivity
- Human
- Molecule Class
- ~ 900 kDa
- Applications
- ELISA, WB, FC, ADCC, CDC
- Conjugate
- None
- Related Disease
- Primary cutaneous CD30+ lymphoproliferative disorders
Product Property
- Clonality
- Monoclonal
- Purification
- Protein A purified
- Purity
- >95% determined as SDS-PAGE and SEC-HPLC
- Aggregation
- <5%
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term (1-2 weeks). Store at -20°C long term (12 months). Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- CCR4; chemokine (C-C motif) receptor 4; CKR4; K5-5; CD194; CMKBR4; ChemR13; CC-CKR-4; HGCN:14099; C-C chemokine receptor type 4; CCR-4; C-C CKR-4; chemokine (C-C) receptor 4
- Gene ID
- 1233
- UniProt ID
- P51679
- Long Name
- C-C Motif Chemokine Receptor 4
- Sequence Similarities
- Belongs to the G-protein coupled receptor 1 family.
- Cellular Localization
- Cell membrane; Multi-pass membrane protein
- Post Translation Modifications
- Glycosylation at Asn183 and Asn194
- Function
- High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1.
The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system.
Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates.
In the CNS, could mediate hippocampal-neuron survival.
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Datasheet
MSDS
COA
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