Human Anti-CCR4 Recombinant Antibody Hexamer (VS-0924-YC106), CDC Enhanced (CAT#: VS-0924-YC106)

The product is a human anti-CCR4 antibody hexamer with enhanced CDC activity. This hexameric IgG1 targets human CCR4 and includes mutations that promote hexamer formation. These mutations enhance C1q binding and increase complement-dependent cytotoxicity (CDC).

Specific Inquiry
  • Size:
  • Conjugation:
  • Endotoxin:
  • Purity:
  • Fc Engineering:
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Normal Tissue
RNA Expression

Specifications

  • Host Species
  • Human
  • Derivation
  • Humanized
  • Type
  • Antibody hexamer
  • Specificity
  • Human CCR4
  • Species Reactivity
  • Human
  • Molecule Class
  • ~ 900 kDa
  • Applications
  • ELISA, WB, FC, ADCC, CDC
  • Conjugate
  • None
  • Related Disease
  • Primary cutaneous CD30+ lymphoproliferative disorders

Product Property

  • Clonality
  • Monoclonal
  • Purification
  • Protein A purified
  • Purity
  • >95% determined as SDS-PAGE and SEC-HPLC
  • Aggregation
  • <5%
  • Buffer
  • PBS, pH 7.4
  • Preservative
  • No preservatives
  • Storage
  • Store at 4°C short term (1-2 weeks). Store at -20°C long term (12 months). Avoid repeated freeze/thaw cycles.

Target

  • Alternative Names
  • CCR4; chemokine (C-C motif) receptor 4; CKR4; K5-5; CD194; CMKBR4; ChemR13; CC-CKR-4; HGCN:14099; C-C chemokine receptor type 4; CCR-4; C-C CKR-4; chemokine (C-C) receptor 4
  • Long Name
  • C-C Motif Chemokine Receptor 4
  • Sequence Similarities
  • Belongs to the G-protein coupled receptor 1 family.
  • Cellular Localization
  • Cell membrane; Multi-pass membrane protein
  • Post Translation Modifications
  • Glycosylation at Asn183 and Asn194
  • Function
  • High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1.
    The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system.
    Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates.
    In the CNS, could mediate hippocampal-neuron survival.

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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