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    CCR4

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    For Research Use Only. Not For Clinical Use.


    Background

    The protein encoded by this gene belongs to the G-protein-coupled receptor family. It is a receptor for the CC chemokineMIP-1, RANTES, TARC and MCP-1. Chemokines are a group of small polypeptide, structurally related molecules that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis.
    CCR4
    Protein class

    CD markers, FDA approved drug targets, G-protein coupled receptors

    Predicted location

    Membrane

    Single cell type specificity

    Cell type enhanced (T-cells, Horizontal cells, granulocytes, Plasma cells, Spermatogonia)

    Immune cell specificity

    Immune cell enriched (T-reg)

    Cell line specificity

    Cell line enriched (HDLM-2)

    Molecular function

    G-protein coupled receptor, Receptor, Transducer

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