Human Anti-CCR4 (clone 208) scFv-Fc Chimera
CAT#: VS-0325-FY56
The anti-CCR4 scFv-Fc antibody is a specialized recombinant protein that was designed to target and bind to the CCR4 (C-C chemokine receptor type 4) protein. This antibody is based on a single-chain variable fragment (scFv) fused to an Fc region to enhance stability, increase half-life in circulation, and improve effector function. CCR4 is primarily expressed on certain immune cells, including Th2 cells, regulatory T cells (Tregs), and is implicated in various inflammatory responses and certain cancers, notably leukemia and lymphomas.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/31613/329_F5_2_selected.jpg
Normal Tissue
Figure 2 IHC staining of human tonsil
Immunohistochemical staining of human tonsil shows strong cytoplasmic positivity in a subset of cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/31613/ihc_selected.jpg
Normal Tissue
Figure 3 Colon
Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/31613/68832_A_8_3.jpg
Normal Tissue
Figure 4 Testis
Leydig cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/31613/68832_A_4_6.jpg
Normal Tissue
Figure 5 Lymph node
Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/31613/68832_A_9_8.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enriched (HDLM-2)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000183813-CCR4
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Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human CCR4
- Species Reactivity
- Human
- Clone
- 208
- Applications
- Flow Cytometry, Inhibition
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- C-C Motif Chemokine Receptor 4; Chemokine (C-C Motif) Receptor 4; C-C CKR-4; CC-CKR-4; CMKBR4; CCR-4; K5-5; C-C Chemokine Receptor Type 4
- Gene ID
- 1233
- UniProt ID
- P51679
- Long Name
- C-C Motif Chemokine Receptor 4
- Sequence Similarities
- Belongs to the G-protein coupled receptor 1 family.
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- In natural killer cells, CCL22 binding induces phosphorylation on yet undefined Ser/Thr residues, most probably by beta-adrenergic receptor kinases 1 and 2.
Glycosylation at Asn183 and Asn194
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 2 sites
- Protein Refseq
- XP_016861176.1; XP_054201145.1; NP_005499.1
- Function
- CCR4 (C-C chemokine receptor type 4) is a chemokine receptor expressed on T cells and other immune cells. It plays a role in immune cell trafficking and is involved in inflammatory responses.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
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- Product Name
Secondary Antibody
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- Product Name
See other products for "Clone 208"
- CAT
- Product Name
See other products for "CCR4"
Select a product category from the dropdown menu below to view related products.
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|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1524CL-S(P) | Anti-Human CCR4 Recombinant Antibody scFv Fragment (406) | FC, Inhib | Human antibody |
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| HPAB-0143-LSX-F(E) | Human Anti-CCR4 Recombinant Antibody; Fab Fragment (HPAB-0143-LSX-F(E)) | ELISA, WB, FC | Humanized Fab |
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| HPAB-0146-LSX-F(E) | Human Anti-CCR4 Recombinant Antibody; Fab Fragment (HPAB-0146-LSX-F(E)) | ELISA, IF | Chimeric (mouse/human) Fab |
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|---|---|---|---|
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