Recombinant Anti-CCR4 Vesicular Antibody, EV Displayed (VS-0425-YC219)
CAT#: VS-0425-YC219
The Recombinant Anti-CCR4 Vesicular Antibody, EV Displayed (VS-0425-YC219) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to CCR4-expressed cells or tissues. The CCR4 is a chemokine receptor associated with diseases like Cutaneous T Cell Lymphoma. It is related to signaling pathways involving chemokine receptor activity.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/31613/329_F5_2_selected.jpg
Normal Tissue
Figure 2 IHC staining of human tonsil
Immunohistochemical staining of human tonsil shows strong cytoplasmic positivity in a subset of cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/31613/ihc_selected.jpg
Normal Tissue
Figure 3 Colon
Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/31613/68832_A_8_3.jpg
Normal Tissue
Figure 4 Testis
Leydig cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/31613/68832_A_4_6.jpg
Normal Tissue
Figure 5 Lymph node
Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/31613/68832_A_9_8.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enriched (HDLM-2)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000183813-CCR4
❮
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Recombinant Antibody
- Application
- ELISA, FC, Neut, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- CCR4
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- C-C motif chemokine receptor 4
- Molecular Function
- G-protein coupled receptor, Receptor, Transducer
- Cellular Localization
- Plasma membrane
- Introduction
- CCR4 (C-C Motif Chemokine Receptor 4) is a Protein Coding gene. Diseases associated with CCR4 include Cutaneous T Cell Lymphoma and Mycosis Fungoides. Among its related pathways are Akt Signaling and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and C-C chemokine receptor activity. An important paralog of this gene is CCR5.
- Alternative Names
- CC-CKR-4, CD194, ChemR13, CKR4, CMKBR4, k5-5
- Gene ID
- 1233
- UniProt ID
- P51679
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBZ-142 | Human Anti-CCR4 Recombinant Antibody (clone KM3060); Fab Fragment | WB | Chimeric (mouse/human) Fab |
| HPAB-0141-LSX-S(P) | Mouse Anti-CCR4 Recombinant Antibody; scFv Fragment (HPAB-0141-LSX-S(P)) | ELISA, WB, FC | Mouse scFv |
| HPAB-0143-LSX-S(P) | Human Anti-CCR4 Recombinant Antibody; scFv Fragment (HPAB-0143-LSX-S(P)) | ELISA, WB, FC | Human scFv |
| HPAB-0144-LSX-S(P) | Human Anti-CCR4 Recombinant Antibody; scFv Fragment (HPAB-0144-LSX-S(P)) | ELISA, WB, FC | Human scFv |
| HPAB-1109WJ-S(P) | Human Anti-CCR4 Recombinant Antibody; scFv Fragment (HPAB-1109WJ-S(P)) | FC | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBZ-142 | Mouse Anti-CCR4 Recombinant Antibody (clone KM3060); scFv Fragment | WB | Mouse scFv |
| HPAB-1777LY-F(E) | Mouse Anti-CCR4 Recombinant Antibody; Fab Fragment (HPAB-1777LY-F(E)) | FC, Inhib, ELISA | Mouse Fab |
| HPAB-1778LY-F(E) | Mouse Anti-CCR4 Recombinant Antibody; Fab Fragment (HPAB-1778LY-F(E)) | FC, Inhib, ELISA | Mouse Fab |
| HPAB-1779LY-F(E) | Mouse Anti-CCR4 Recombinant Antibody; Fab Fragment (HPAB-1779LY-F(E)) | FC, Inhib, ELISA | Mouse Fab |
| HPAB-1780LY-F(E) | Human Anti-CCR4 Recombinant Antibody; Fab Fragment (HPAB-1780LY-F(E)) | FC, Inhib, ELISA | Humanized Fab |
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|---|---|---|---|
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| TAB-1522CL | Anti-Human CCR4 Recombinant Antibody (306) | FC, Inhib | Human antibody |
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| TAB-1524CL | Anti-Human CCR4 Recombinant Antibody (406) | FC, Inhib | Human antibody |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY56 | Human Anti-CCR4 (clone 208) scFv-Fc Chimera | FC, Inhib | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1101 | Anti-CCR4 Immunohistochemistry Kit | IHC |
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