SmartAb™ Recombinant Anti-CD96 pH-dependent Antibody (Clone 6A6)
CAT#: VS-0825-YC72
The anti-CD96 pH-dependent antibody (clone 6A6) is a recombinant monoclonal antibody that exhibits pH-dependent antigen binding to mouse CD96. By introducing histidine mutations that act as a pH-switch, the antibody demonstrates a preferential affinity for CD96 under acidic conditions compared to physiological pH. Using a yeast surface display system with pH-dependent screening pressure, this mAb is identified which shows a significant increase in dissociation from CD96 at pH 6.0. This pH-sensitive antibody retains its binding affinity for CD96 on tumor cells while exhibiting negligible binding to the receptor on normal cells at physiological pH. Mouse CD96 is an activating receptor expressed on T-cells and NK cells that promotes cytotoxicity. It is involved in both anti-tumor and anti-viral immune responses, making it a potential target for cancer immunotherapy.
Gene Expression
Normal Tissue
Figure 1 Small intestine
High expression
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/66754/155816_A_4_2_selected.jpg
Normal Tissue
Figure 2 Lymph node
Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/66754/155816_A_7_8.jpg
Normal Tissue
Figure 3 Spleen
Cells in white pulp Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/66754/155816_B_7_4.jpg
RNA Expression
Figure 4 RNA cell line category: Cell line enhanced (HEL, JURKAT, MOLT-4, RT4, U-937)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000153283-CD96
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Specifications
- Immunogen
- Recombinant mouse CD96 protein.
- Host Species
- Mouse
- Type
- Mouse IgG1
- Specificity
- Mouse CD96
- Species Reactivity
- Mouse
- Clone
- 6A6
- Applications
- Block, FC
Product Property
- Clonality
- Monoclonal
- Purification
- Protein G purified
- Purity
- >95%, determined by SDS-PAGE and SEC-HPLC
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- For short-term storage, keep it at 4°C for up to two weeks. For long-term storage, divide the solution into aliquots and freeze them at -20°C or below.
Target
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Clone 6A6"
- CAT
- Product Name
See other products for "CD96"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| CBPAB-601NL | Recombinant Anti-human CD96 Antibody | WB, IHC-P, IHC-Fr, P-ELISA | |
| FAMAB-1764CQ | Mouse Anti-CD96 Recombinant Antibody (clone 6A6) | Block, FC | Mouse IgG1 |
| VS4-WK95 | Human Anti-CD96 Recombinant Antibody (clone 4A4) | ELISA | Human IgG1 |
| VS7-HM655 | Mouse Anti-CD96 Recombinant Antibody (clone 5E6C12) | WB, FCM | Mouse IgG2b |
| VS7-HM656 | Mouse Anti-CD96 Recombinant Antibody (clone 8A11F8) | FCM | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-438CQ | Mouse Anti-CD96 Recombinant Antibody (clone NK92.39) | Block, FuncS, FC | Mouse IgG1 |
| NEUT-439CQ | Rat Anti-Cd96 Recombinant Antibody (clone 3.3) | FC, Block | Rat IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC682 | Recombinant Anti-CD96 Vesicular Antibody, EV Displayed (VS-0425-YC682) | Block, ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1249 | Anti-CD96 Immunohistochemistry Kit | IHC |
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