CytoStream™ Rabbit Anti-CDK6 Recombinant Antibody (VS13-YC200)
CAT#: VS13-YC200
The CytoStream™ Rabbit Anti-CDK6 Recombinant Antibody is specific for human CDK6. CDK6 is associated with cell cycle regulation, overexpressed in cancers like lymphoma and leukemia due to its kinase activity. The anti-CDK6 antibody was developed and selected by our CytoStream™ platform and the mAb is recommended for use in flow cytometry staining (1/50-1/100).
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2637/37_E3_2_selected.jpg
Normal Tissue
Figure 2 High expression in placenta
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2637/10679_A_2_7_val_selected.jpg
Normal Tissue
Figure 3 Bone marrow
Hematopoietic cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2637/10679_B_4_4.jpg
Normal Tissue
Figure 4 Lymph node
Germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2637/10679_A_8_8.jpg
Normal Tissue
Figure 5 Cerebral cortex
Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2637/10679_B_8_5.jpg
Normal Tissue
Figure 6 Colon
Enterocytes Staining: Low Intensity: Moderate Quantity: <25% Enterocytes - Gradient Gradient: Descending Enterocytes - Mucosal lymphoid cells Staining: Low Intensity: Moderate
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2637/10679_A_9_3.jpg
Normal Tissue
Figure 7 Testis
Pachytene spermatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Preleptotene spermatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Spermatogonia cells Staining: Medium Intensity: Moderate
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2637/10679_A_6_6.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced (MOLT-4, REH)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000105810-CDK6
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Specifications
- Immunogen
- Recombinant human Cdk6, aa 277-326.
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human CDK6
- Species Reactivity
- Human
- Applications
- WB, ICC, IF, IHC-P, FC
- Conjugate
- NONE
- Related Disease
- Lymphoma, Leukemia, Medulloblastoma and Melanoma
Product Property
- Clonality
- Monoclonal
- Purification
- Protein A purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- TBS (pH 7.4) containing 40% Glycerol and 0.05% BSA.
- Preservative
- 0.05% Sodium azide
- Storage
- Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Shipping with ice pack.
Applications
- Application Notes
- Western blot (WB): 1/500-1/2000
Immunocytochemistry (ICC): 1/50-1/200
Immunofluorescence (IF): 1/50-1/200
Immunohistochemistry-paraffin (IHC-P): 1/50-1/200
Flow cytometry (FC): 1/50-1/100
Target
- Alternative Names
- Cyclin Dependent Kinase 6; Serine/Threonine-Protein Kinase PLSTIRE; Cell Division Protein Kinase 6; EC 2.7.11.22; Cyclin-Dependent Kinase 6; EC 2.7.11; PLSTIRE; MCPH12; CDKN6;
- Gene ID
- 1021
- UniProt ID
- Q00534
- Long Name
- Cyclin Dependent Kinase 6
- Cellular Localization
- Nucleus; Cytoplasm; Cell projection
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Related Signaling Pathways
p53 Signaling Pathway
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "CDK6"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2214z | Mouse Anti-CDK6 Recombinant Antibody (clone 37A9) | WB, ELISA, IF, IHC | Mouse IgG1, κ |
| MRO-0343-CN | Rabbit Anti-CDK6 Recombinant Antibody (clone CBACN-141) | WB, IF, IHC, FC | Rabbit IgG |
| ZG-0799F | Mouse Anti-CDK6 Recombinant Antibody (clone DCS83.1) | WB, IP, IHC | Mouse IgG1 |
| ZG-0614J | Rabbit Anti-CDK6 Recombinant Antibody (clone 8G3) | ELISA, WB, IP | Rabbit IgG |
| VS3-WK832 | Rabbit Anti-CDK6 Recombinant Antibody (VS3-WK832) | WB, ICC, IF, IHC, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0634 | Hi-Affi™ Rabbit Anti-CDK6 Recombinant Antibody (clone DS634AB) | WB, IHC, ICC, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY408 | Anti-CDK6 Immunohistochemistry Kit | IHC | |
| VS-0525-XY1321 | Anti-Human CDK6 Immunohistochemistry Kit | IHC |
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