CytoStream™ Rabbit Anti-CDK6 Recombinant Antibody (VS13-YC200) (CAT#: VS13-YC200)
The CytoStream™ Rabbit Anti-CDK6 Recombinant Antibody is specific for human CDK6. CDK6 is associated with cell cycle regulation, overexpressed in cancers like lymphoma and leukemia due to its kinase activity. The anti-CDK6 antibody was developed and selected by our CytoStream™ platform and the mAb is recommended for use in flow cytometry staining (1/50-1/100).
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Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2637/37_E3_2_selected.jpg
(Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2637/37_E3_2_selected.jpg
Figure 2 High expression in placenta
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2637/10679_A_2_7_val_selected.jpg
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2637/10679_A_2_7_val_selected.jpg
Figure 3 Bone marrow
(Hematopoietic cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2637/10679_B_4_4.jpg
(Hematopoietic cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2637/10679_B_4_4.jpg
Figure 4 Lymph node
(Germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2637/10679_A_8_8.jpg
(Germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2637/10679_A_8_8.jpg
Figure 5 Cerebral cortex
(Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2637/10679_B_8_5.jpg
(Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2637/10679_B_8_5.jpg
Figure 6 Colon
(Enterocytes Staining: Low Intensity: Moderate Quantity: <25% Enterocytes - Gradient Gradient: Descending Enterocytes - Mucosal lymphoid cells Staining: Low Intensity: Moderate)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2637/10679_A_9_3.jpg
(Enterocytes Staining: Low Intensity: Moderate Quantity: <25% Enterocytes - Gradient Gradient: Descending Enterocytes - Mucosal lymphoid cells Staining: Low Intensity: Moderate)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2637/10679_A_9_3.jpg
Figure 7 Testis
(Pachytene spermatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Preleptotene spermatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Spermatogonia cells Staining: Medium Intensity: Moderate)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2637/10679_A_6_6.jpg
(Pachytene spermatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Preleptotene spermatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Spermatogonia cells Staining: Medium Intensity: Moderate)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2637/10679_A_6_6.jpg
Figure 8 RNA cell line category: Cell line enhanced (MOLT-4, REH)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000105810-CDK6
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000105810-CDK6
Specifications
- Immunogen
- Recombinant human Cdk6, aa 277-326.
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human CDK6
- Species Reactivity
- Human
- Applications
- WB, ICC, IF, IHC-P, FC
- Conjugate
- NONE
- Related Disease
- Lymphoma, Leukemia, Medulloblastoma and Melanoma
Product Property
- Clonality
- Monoclonal
- Purification
- Protein A purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- TBS (pH 7.4) containing 40% Glycerol and 0.05% BSA.
- Preservative
- 0.05% Sodium azide
- Storage
- Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Shipping with ice pack.
Applications
- Application Notes
- Western blot (WB): 1/500-1/2000
Immunocytochemistry (ICC): 1/50-1/200
Immunofluorescence (IF): 1/50-1/200
Immunohistochemistry-paraffin (IHC-P): 1/50-1/200
Flow cytometry (FC): 1/50-1/100
Target
- Alternative Names
- Cyclin Dependent Kinase 6; Serine/Threonine-Protein Kinase PLSTIRE; Cell Division Protein Kinase 6; EC 2.7.11.22; Cyclin-Dependent Kinase 6; EC 2.7.11; PLSTIRE; MCPH12; CDKN6;
- Gene ID
- 1021
- UniProt ID
- Q00534
- Long Name
- Cyclin Dependent Kinase 6
- Cellular Localization
- Nucleus; Cytoplasm; Cell projection
Recommended Products
Secondary Antibody
Isotype Control
Related Resources
p53 Signaling Pathway
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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IHC Kit and Antibody Products: Precision Tools for Immunohistochemistry
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2477MZ | Recombinant Mouse Anti-Human CDK6 Antibody | ICC/IF, IHC-P, WB | Mouse antibody |
| MRO-1768-CN | Rabbit Anti-CDK6 Polyclonal Antibody (MRO-1768-CN) | WB, IF, IHC | Rabbit IgG |
| ZG-0614J | Rabbit Anti-CDK6 Recombinant Antibody (clone 8G3) | ELISA, WB, IP | Rabbit IgG |
| VS3-WK832 | Rabbit Anti-CDK6 Recombinant Antibody (VS3-WK832) | WB, ICC, IF, IHC, FC | Rabbit IgG |
| VS3-FY349 | Recombinant Rabbit Anti-CDK6 Antibody (clone R03-2G5) | WB, ICC, IF | Rabbit IgG |
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