Rabbit Anti-CEACAM6 Recombinant Antibody (clone R06-4A5) (CAT#: VS3-XY3311)

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Specificity
• Human, Mouse and Rat CEACAM6

• Species Reactivity
• Human, Mouse, Rat

• Clone
• R06-4A5

• Applications
• WB, IHC-P, ICC, IF, IP

• Related Disease
• Cystic Fibrosis; Gastrointestinal Carcinoma

• Clonality
• Monoclonal

• Aggregation
• < 5%

• Format
• Liquid

• Buffer
• PBS (pH 7.4), 150 mM NaCl and 50% glycerol

• Preservative
• 0.02% sodium azide

• Storage
• Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• WB: 1/500-1/1000
  IHC: 1/50-1/100
  IF: 1/50-1/200
  IP: 1/20

• Alternative Names
• NCA; CEAL; CD66c; NCA-50/90

• Gene ID
• 4680

• UniProt ID
• P40199

• Long Name
• CEA cell adhesion molecule 6

• Cellular Localization
• Cell membrane, Cell surface

• Post Translation Modifications
• Glycosylated. (P40199-CEAM6_HUMAN)
  Glycosylation at Asn104, Asn111, Asn115, Asn152, Asn173, Asn197, Asn224, Asn256, Asn274, Asn288, Asn292, and Asn309 (NX_P40199 [NX_P40199-1])
  Modification sites at PhosphoSitePlus (P40199)
  Glycosylation from GlyGen (P40199) 16 sites, 6 N-linked glycans (3 sites), 1 O-linked glycan (2 sites)

• Protein Refseq
• XP_011525292.1; XP_054177043.1; NP_002474.4

• Function
• Cell surface glycoprotein that plays a role in cell adhesion and tumor progression. Intercellular adhesion occurs in a calcium- and fibronectin-independent manner. Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM5 and CEACAM8. Heterophilic interaction with CEACAM8 ^oCcurs in activated neutrophils. Plays a role in neutrophil adhesion to cytokine-activated endothelial cells.

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody

Recommended Dilution Buffer

• MRO-0253YJ
• Reconstitution Buffer PBS

Secondary Antibody

• 2RD-A1473-YJ
• Goat Anti-Rabbit IgG-F(ab')2 Secondary antibody