Rabbit Anti-CEACAM6 Recombinant Antibody (clone R06-4A5)
CAT#: VS3-XY3311
The rabbit recombinant antibody specifically recognizes CEACAM6 (CEA cell adhesion molecule 6), which is a cell surface glycoprotein playing a role in cell adhesion and tumor progression. It specifically reacts with human, mouse and rat CEACAM6. It has been tested using Western Blot, Immunohistochemistry-Paraffin, Immunoprecipitation, Immunocytochemistry or Immunofluorescence. The recommended dilutions of Western Blot, Immunohistochemistry-Paraffin, Immunoprecipitation and Immunofluorescence is 1/500-1/1000, 1/50-1/100, 1/20 and 1/50-1/200, respectively.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human duodenum
Immunohistochemical staining of human duodenum shows strong cytoplasmic positivity in a subset of leukocytes.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/11041/ihc_selected.jpg
Normal Tissue
Figure 2 High expression in lung.
Macrophages Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/11041/27139_A_3_4.jpg
Normal Tissue
Figure 3 Colon
Enterocytes - Microvilli Staining: Medium Intensity: Moderate Mucosal lymphoid cells Staining: Medium Intensity: Strong
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/11041/27139_A_9_3.jpg
Normal Tissue
Figure 4 Lymph node
Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/11041/27139_A_8_8.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enriched (OE19)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000086548-CEACAM6
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Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat CEACAM6
- Species Reactivity
- Human, Mouse, Rat
- Clone
- R06-4A5
- Applications
- WB, IHC-P, ICC, IF, IP
- Related Disease
- Cystic Fibrosis; Gastrointestinal Carcinoma
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- WB: 1/500-1/1000
IHC: 1/50-1/100
IF: 1/50-1/200
IP: 1/20
Target
- Alternative Names
- NCA; CEAL; CD66c; NCA-50/90
- Gene ID
- 4680
- UniProt ID
- P40199
- Long Name
- CEA cell adhesion molecule 6
- Cellular Localization
- Cell membrane, Cell surface
- Post Translation Modifications
- Glycosylated. (P40199-CEAM6_HUMAN)
Glycosylation at Asn104, Asn111, Asn115, Asn152, Asn173, Asn197, Asn224, Asn256, Asn274, Asn288, Asn292, and Asn309 (NX_P40199 [NX_P40199-1])
Modification sites at PhosphoSitePlus (P40199)
Glycosylation from GlyGen (P40199) 16 sites, 6 N-linked glycans (3 sites), 1 O-linked glycan (2 sites)
- Protein Refseq
- XP_011525292.1; XP_054177043.1; NP_002474.4
- Function
- Cell surface glycoprotein that plays a role in cell adhesion and tumor progression. Intercellular adhesion occurs in a calcium- and fibronectin-independent manner. Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM5 and CEACAM8. Heterophilic interaction with CEACAM8 oCcurs in activated neutrophils. Plays a role in neutrophil adhesion to cytokine-activated endothelial cells.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Isotype Control
- CAT
- Product Name
Recommended Dilution Buffer
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "CEACAM6"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1445z | Mouse Anti-CEACAM6 Recombinant Antibody (clone 29F3) | WB, IP, IF, IHC, FC | Mouse IgG1, κ |
| VS-0723-WK31 | Human Anti-CEACAM6 Recombinant Antibody (clone Tinurilimab) | ELISA, FC | Human IgG2 |
| VS-0723-WK62 | Human Anti-CEACAM6 Recombinant Antibody (VS-0723-WK62) | FC | Chimeric (rabbit/human) IgG1 |
| VS7-HM698 | Mouse Anti-CEACAM6 Recombinant Antibody (clone 3H4A5) | WB, IHC, ICC, FCM | Mouse IgG1 |
| VS7-HM699 | Mouse Anti-CEACAM6 Recombinant Antibody (clone 4B9F1) | IHC, ICC, FCM | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABG-042 | Recombinant Anti-Human CEACAM6 VHH Single Domain Antibody | ELISA, IHC, FC, FuncS | Llama VHH |
| TAB-004LC-VHH | Anti-Human CEACAM6 Recombinant Antibody (TAB-004LC-VHH) | ELISA, WB, FC, Inhib, FuncS, ICC, SPR | Single domain antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-444LC | Anti-Human CEACAM6 Recombinant Antibody (TAB-444LC) | IHC, ELISA, FC, WB, ADCC, FuncS | Humanized antibody |
| TAB-446LC | Human Anti-CEACAM6 Recombinant Antibody (TAB-446LC) | WB, IHC | Humanized antibody |
| TAB-447LC | Human Anti-CEACAM6 Recombinant Antibody (TAB-447LC) | WB, IHC | Humanized antibody |
| TAB-448LC | Human Anti-CEACAM6 Recombinant Antibody (TAB-448LC) | WB, IHC | Humanized antibody |
| TAB-449LC | Human Anti-CEACAM6 Recombinant Antibody (TAB-449LC) | WB, IHC | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-445LC | Mouse Anti-CEACAM6 Recombinant Antibody (TAB-445LC) | ELISA, FC, IHC | Mouse IgG1, κ |
| TAB-477MZ | Mouse Anti-CEACAM6 Recombinant Antibody (TAB-477MZ) | ELISA, FuncS | Mouse IgG |
| TAB-478MZ | Mouse Anti-CEACAM6 Recombinant Antibody (TAB-478MZ) | ELISA | Mouse IgG |
| TAB-477MZ-S(P) | Mouse Anti-CEACAM6 Recombinant Antibody; scFv Fragment (TAB-477MZ-S(P)) | ELISA | Mouse scFv |
| TAB-478MZ-S(P) | Mouse Anti-CEACAM6 Recombinant Antibody; scFv Fragment (TAB-478MZ-S(P)) | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0650 | Hi-Affi™ Rabbit Anti-CEACAM6 Recombinant Antibody (clone DS650AB) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0283-CN-S(P) | Human Anti-CEACAM6 Recombinant Antibody; scFv Fragment (HPAB-0283-CN-S(P)) | ELISA, WB, FC | Human scFv |
| HPAB-0284-CN-S(P) | Mouse Anti-CEACAM6 Recombinant Antibody; scFv Fragment (HPAB-0284-CN-S(P)) | ELISA, WB, FC | Mouse scFv |
| HPAB-0285-CN-S(P) | Mouse Anti-CEACAM6 Recombinant Antibody; scFv Fragment (HPAB-0285-CN-S(P)) | ELISA, WB, FC | Mouse scFv |
| HPAB-0286-CN-S(P) | Human Anti-CEACAM6 Recombinant Antibody; scFv Fragment (HPAB-0286-CN-S(P)) | ELISA, WB, FC | Humanized scFv |
| HPAB-N0336-YC-S(P) | Human Anti-CEACAM6 Recombinant Antibody; scFv Fragment (HPAB-N0336-YC-S(P)) | FC, ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0283-CN-F(E) | Human Anti-CEACAM6 Recombinant Antibody; Fab Fragment (HPAB-0283-CN-F(E)) | ELISA, WB, FC | Human Fab |
| HPAB-0284-CN-F(E) | Mouse Anti-CEACAM6 Recombinant Antibody; Fab Fragment (HPAB-0284-CN-F(E)) | ELISA, WB, FC | Mouse Fab |
| HPAB-0285-CN-F(E) | Mouse Anti-CEACAM6 Recombinant Antibody; Fab Fragment (HPAB-0285-CN-F(E)) | ELISA, WB, FC | Mouse Fab |
| HPAB-0286-CN-F(E) | Human Anti-CEACAM6 Recombinant Antibody; Fab Fragment (HPAB-0286-CN-F(E)) | ELISA, WB, FC | Humanized Fab |
| HPAB-N0045-YC-F(E) | Mouse Anti-CEACAM6 Recombinant Antibody; Fab Fragment (HPAB-N0045-YC-F(E)) | FC, WB, IP | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY62 | AbPlus™ Anti-CEACAM6 Magnetic Beads (VS-0424-XY62) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY179 | Mouse Anti-CEACAM6 scFv-Fc Chimera (VS-0325-FY179) | WB, IHC | Mouse IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC147 | Recombinant Anti-CEACAM6 Vesicular Antibody, EV Displayed (VS-0425-YC147) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1357 | Anti-CEACAM6 Immunohistochemistry Kit | IHC | |
| VS-0525-XY1358 | Anti-Mouse CEACAM6 Immunohistochemistry Kit | IHC |
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