Anti-CHI3L1 (clone W24V88) Recombinant Antibody Coupled Liposome (VS-1024-FY90) (CAT#: VS-1024-FY90)

• Potential Clinical Applications
• Glioma

• Clone
• W24V88

• Antibody Type
• IgG

• Antibody Host
• Human

• Antibody Reactivity
• Human

• Antibody Description
• This is a recombinant human monoclonal antibody that is engineered to specifically bind to human CHI3L1, a glycoprotein that plays a significant role in various biological processes, including inflammation and tissue remodeling.

• Storage
• See in the COA

• Storage Shelf Time
• See in the COA

• Target
• CHI3L1

• Introduction
• Chitinases catalyze the hydrolysis of chitin, which is an abundant glycopolymer found in insect exoskeletons and fungal cell walls. The glycoside hydrolase 18 family of chitinases includes eight human family members. This gene encodes a glycoprotein member of the glycosyl hydrolase 18 family. The protein lacks chitinase activity and is secreted by activated macrophages, chondrocytes, neutrophils and synovial cells. The protein is thought to play a role in the process of inflammation and tissue remodeling.

• Alternative Names
• ASRT7; CGP-39; GP-39; GP39; HC-gp39; HCGP-3P; hCGP-39; YK-40; YKL-40; YKL40; YYL-40

• Full Name
• Chitinase 3 Like 1

• Gene ID
• 1116

• UniProt ID
• P36222

• Sequence Similarities
• Belongs to the glycosyl hydrolase 18 family.

• Cellular Localization
• Secreted, extracellular space; Cytoplasm

• Post Translation Modifications
• Glycosylated. ( P36222-CH3L1_HUMAN )
  Glycosylation at Asn60 ( NX_P36222 [NX_P36222-1] )
  Modification sites at PhosphoSitePlus ( P36222 )
  Glycosylation from GlyGen (P36222) 2 sites

• Protein Refseq
• XP_047298796.1; XP_047298797.1; XP_047298802.1; XP_047298803.1; XP_047298804.1

• Function
• May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment.
  Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation.
  Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs.

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