Mouse Anti-CHRM2 Recombinant Antibody (VS3-CJ487)
CAT#: VS3-CJ487
This product is a mouse antibody that recognizes human, and mouse CHRM2.
Gene Expression
Normal Tissue
Figure 1 Cerebral cortex
ndothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Neuronal cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Neuropil
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/22338/62925_B_8_5.jpg
Normal Tissue
Figure 2 Colon
Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Peripheral nerve/ganglion
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/22338/62925_A_8_3.jpg
Normal Tissue
Figure 3 Liver
Hepatocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/22338/62925_A_9_4.jpg
Normal Tissue
Figure 4 Kidney
Cells in tubules
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/22338/62925_A_7_5.jpg
Normal Tissue
Figure 5 Testis
Cells in seminiferous ducts
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Leydig cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/22338/62925_A_6_6.jpg
Normal Tissue
Figure 6 Heart muscle
Cardiomyocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/29795/62923_B_6_6.jpg
Normal Tissue
Figure 7 Lymph node
Germinal center cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/22338/62925_A_7_8.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enriched (fHDF/TERT166)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000181072-CHRM2
❮
❯
Specifications
- Immunogen
- Recombinant protein
- Host Species
- Mouse
- Type
- Mouse IgG1, κ
- Specificity
- Human, Mouse CHRM2
- Species Reactivity
- Human, Mouse
- Applications
- WB, IF, IHC-P, FC
- Conjugate
- Unconjugated
Product Property
- Purification
- Protein G affinity purified
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Buffer
- PBS, pH 7.3.
- Preservative
- 0.09% Sodium Azide
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been tested for use in Western Blot (1:1000), Immunofluorescence (1:25), Immunohistochemistry-Parraffin (1:25), Flow Cytometry (1:25).
Target
- Alternative Names
- HM2
- Gene ID
- 1129
- UniProt ID
- P08172
- Sequence Similarities
- Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM2 sub-subfamily.
- Cellular Localization
- Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse
- Post Translation Modifications
- Phosphorylated in response to agonist treatment.
- Protein Refseq
- NP_000730.1; NP_001006627.1; NP_001006628.1
- Function
- The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol.
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Secondary Antibody
- CAT
- Product Name
Recommended Dilution Buffer
- CAT
- Product Name
See other products for "CHRM2"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-205 | Recombinant Anti-human CHRM2 Antibody | ELISA, WB, IP, FuncS | IgG |
| MHH-205 | Recombinant Human Anti-human CHRM2 Antibody | ELISA, WB, FC, FuncS | IgG |
| VS3-QX236 | Mouse Anti-CHRM2 Recombinant Antibody (clone 1424CT461.78.60) | ICC, IHC, FC | Mouse IgG1, κ |
| VS3-FY383 | Recombinant Rabbit Anti-CHRM2 Antibody (clone R01-9B9) | WB, IHC-P, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-205-F(E) | Recombinant Anti-human CHRM2 Antibody Fab Fragment | WB, IF, FuncS | Fab |
| MHH-205-F(E) | Recombinant Human Anti-human CHRM2 Antibody Fab Fragment | IP, FuncS | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-205-S(P) | Recombinant Anti-human CHRM2 Antibody scFv Fragment | FC, Neut, Biosensors, FuncS | scFv |
| MHH-205-S(P) | Recombinant Human Anti-human CHRM2 Antibody scFv Fragment | RIA, ELISA, FuncS | scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABL-081 | Recombinant Anti-human CHRM2 VHH Single Domain Antibody | WB, ELISA, IP, FuncS | Llama VHH |
| HPAB-0354-YJ-VHH | Recombinant Llama Anti-CHRM2 Single Domain Antibody (HPAB-0354-YJ-VHH) | FC | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0697 | Hi-Affi™ Rabbit Anti-CHRM2 Recombinant Antibody (clone DS697AB) | WB, IHC, ICC, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-058CN | Human Anti-CHRM2 Recombinant Antibody (clone P90-131) | RIA, ELISA, WB, IP, IF | Human IgG |
| NS-058CN-F(E) | Human Anti-CHRM2 Recombinant Antibody (clone P90-131); Fab Fragment | RIA, ELISA, WB, IP, IF | Human Fab |
| NS-058CN-S(P) | Human Anti-CHRM2 Recombinant Antibody (clone P90-131); scFv Fragment | RIA, ELISA, WB, IP, IF | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY65 | AbPlus™ Anti-CHRM2 Magnetic Beads (P90-131) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC439 | Recombinant Anti-CHRM2 Vesicular Antibody, EV Displayed (VS-0425-YC439) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1449 | Anti-CHRM2 Immunohistochemistry Kit | IHC | |
| VS-0525-XY1450 | Anti-Mouse CHRM2 Immunohistochemistry Kit | IHC | |
| VS-0525-XY1451 | Anti-Rat CHRM2 Immunohistochemistry Kit | IHC |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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