Mouse Anti-CLEC12A Recombinant Antibody Hexamer (VS-0924-YC125), CDC Enhanced (CAT#: VS-0924-YC125)

• Immunogen
• Human CLL-1

• Host Species
• Mouse

• Type
• Antibody hexamer

• Specificity
• Human and Monkey CLEC12A

• Species Reactivity
• Human, Monkey

• Molecule Class
• ~ 900 kDa

• Applications
• CDC

• Conjugate
• None

• Related Disease
• Acute myeloid leukemia

• Clonality
• Monoclonal

• Purification
• Protein G purified

• Purity
• >95% determined as SDS-PAGE and SEC-HPLC

• Aggregation
• <5%

• Buffer
• PBS, pH 7.4

• Preservative
• No preservatives

• Storage
• Store at 4°C short term (1-2 weeks). Store at -20°C long term (12 months). Avoid repeated freeze/thaw cycles.

• Alternative Names
• CLEC12A; C-type lectin domain family 12, member A; CLL1; MICL; CLL-1; DCAL-2; C-type lectin domain family 12 member A; C-type lectin protein CLL-1; C-type lectin-like molecule-1; dendritic cell-associated lectin 2; myeloid inhibitory C-type lectin-like receptor

• Gene ID
• 160364

• UniProt ID
• Q5QGZ9

• Long Name
• C-Type Lectin Domain Family 12 Member A

• Sequence Similarities
• Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.

• Cellular Localization
• Cell membrane; Single-pass type II membrane protein

• Post Translation Modifications
• Highly N-glycosylated.
  Glycosylation varies between cell types.
  ( Q5QGZ9-CL12A_HUMAN )
  Glycosylation at Asn80, Asn88, Asn98, Asn105, Asn165, and Asn210 ( NX_Q5QGZ9 [NX_Q5QGZ9-2] )

• Function
• Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases.

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